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The protein encoded by HPD is an enzyme in the catabolic pathway of tyrosine. Additionally we are shipping HPD Proteins (23) and HPD Kits (19) and many more products for this protein.
Showing 10 out of 94 products:
Human Monoclonal HPD Primary Antibody for ICC, FACS - ABIN438818
Dorrell, Abraham, Lanxon-Cookson, Canaday, Streeter, Grompe: Isolation of major pancreatic cell types and long-term culture-initiating cells using novel human surface markers. in Stem cell research 2009
The mutagenesis and structural simulation studies demonstrate the critical and unique role of each ligand in the function of HPPD, and which correlates with their respective co-ordination position.
4-hydroxyphenylpyruvate dioxygenase gene mutation is associated with Hawkinsinuria.
Glutamine375 has a critical role for 4-HPPD in orientating the tail and ensuring the conformation of the terminal alpha-helix of the enzyme to maintain the integrity of the active site for biocatalysis.
The IIe335Met allele is equivalent to a null mutation while the Asn241Ser allele results in a partially active enzyme with an uncoupled turnover causing elevated haykinin in urine.
We observed long-term postnatal persistence of edited cells in both models, with reduction of plasma PCSK9 and cholesterol levels following in utero Pcsk9 targeting and rescue of the lethal phenotype of hereditary tyrosinemia type 1 following in utero Hpd targeting
Gene expressions in tyrosinemia type I model mice with liver failure using microarrays. Numerous genes, including amino acid metabolism and apoptosis related genes, were up- or down-regulated at the onset of liver failure.
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.
, 4-hydroxyphenylpyruvic acid oxidase
, p-hydroxyphenylpyruvic hydroxylase
, 4-hydroxyphenylpyruvic acid dioxygenase
, f Alloantigen
, f protein
, glyoxalase domain containing 3
, F liver antigen