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NT5C encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Additionally we are shipping 5',3'-Nucleotidase, Cytosolic Antibodies (25) and 5',3'-Nucleotidase, Cytosolic Proteins (8) and many more products for this protein.
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Data show that PN-I shows a higher affinity for oxynucleosides rather than deoxynucleosides, while the opposite is true for PN-II.
Mutation analysis in the P5N-I gene led to the identification of 3 novel mutations
This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene.
5' nucleotidase, deoxy (pyrimidine), cytosolic type C
, 5'(3')-deoxyribonucleotidase, cytosolic type
, cytosolic 5',3'-pyrimidine nucleotidase
, deoxy-5'-nucleotidase 1
, uridine 5'-monophosphate phosphohydrolase 2
, uridine 5-prime monophosphate hydrolase 2
, uridine monophosphatase 2