5'-3' Exoribonuclease 2 (XRN2) ELISA Kits

XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. Additionally we are shipping XRN2 Antibodies (52) and XRN2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
XRN2 22803 Q9H0D6
XRN2 24128 Q9DBR1
Anti-Rat XRN2 XRN2 362229  
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Top XRN2 ELISA Kits at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Chicken
  96 Tests Log in to see 15 to 18 Days
$1,095.60
Details

More ELISA Kits for XRN2 Interaction Partners

Human 5'-3' Exoribonuclease 2 (XRN2) interaction partners

  1. Xrn2 depletion induces a transcriptional termination defect at the majority of protein-coding genes.

  2. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step.

  3. XRN2 is a novel regulator of EMT that contributes to the metastatic processes in lung cancer through a novel miRNA regulatory mechanism.

  4. XRN2 has a role in R-loop resolution, suppression of replication stress, and maintenance of genomic stability

  5. Chromatin immunoprecipitation experiments further show that IL-1 stimulation leads to decrease in NKRF aa 421-429 phosphorylation and dissociation of NELF-E and XRN2 by concomitant resumption of transcription elongation of a synthetic reporter

  6. P-TEFb regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2.

  7. The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus.

  8. Kinetic competition between elongating pol II and the Xrn2 exonuclease is integral to termination of transcription on most human genes.

  9. found that the 3' fragments of target pre-mRNA generated by ASO were almost completely degraded from their 5' ends by nuclear XRN2 after RNase H1-mediated cleavage

  10. The restriction of JFH1 and H77D hepatitis C virus replication by Xrn2 is likely indirect in nature and possibly linked to cytopathic effects of these robustly replicating viruses.

  11. Xrn2 has a cytoplasmic, antiviral function against HCV that is counteracted by HCV's subversion of miR-122 to form a protective oligomeric complex at the 5' end of the viral genome.

  12. Mammalian target of rapamycin protein regulates the diffusion of Xrn2 from the nucleolus to the nucleoplasm under heat stress conditions.

  13. hnRNPK may play a role in recruitment of XRN2 to gene loci thus regulating coupling 3'-end pre-mRNA processing to transcription termination.

  14. Microprocessor orchestrates the recruitment of termination factors Setx and Xrn2, and the 3'-5' exoribonuclease, Rrp6, to initiate RNAPII pausing and premature termination at the HIV-1 promoter through cleavage of the stem-loop RNA, TAR.

  15. Xrn2 associated with and co-transcriptionally degraded nascent beta-globin transcripts. Evidence was provided that many endogenous pre-mRNAs are also co-transcriptionally degraded by Xrn2 when their processing is inhibited by Spliceostatin A.

  16. Xrn2 has a role in control of transcription by RNA polymerase II.

  17. The results predict that senataxin is required for the resolution of R-loops formed downstream of the poly(A) signal, allowing Xrn2 recruitment and efficient Pol II transcriptional termination.

  18. Genetic variants regulating Xrn2 expression in cis are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings.

  19. co-transcriptional cleavage acts as a precursor to termination by presenting a free RNA 5' end that is recognized by the human 5' --> 3' exonuclease Xrn2

  20. XRN2b is mainly expressed in blood leukocyte tissue, while XRN2a is detected in several human tissues and in human tumor tissues

Mouse (Murine) 5'-3' Exoribonuclease 2 (XRN2) interaction partners

  1. Nkx2-5 genetically interacts with Xrn2 because Nkx2-5(+/-)Xrn2(+/-), but neither Nkx2-5(+/-)nor Xrn2(+/-), newborns exhibited a defect in ventricular septum formation, suggesting that the association between Nkx2-5 and Xrn2 is essential for heart development.

  2. Genetic variants regulating Xrn2 expression in cis are determinants of spontaneous lung tumor susceptibility in mice and have genetic equivalents in lung cancer susceptibility in human beings.

Arabidopsis thaliana 5'-3' Exoribonuclease 2 (XRN2) interaction partners

  1. AtXRN2 has a role in ribosomal RNA processing.

  2. The nuclear exoribonucleases XRN2 and XRN3 the nucleotidase/phosphatase FIERY1 are endogenous posttranscriptional gene silencing suppressors.

XRN2 Antigen Profile

Antigen Summary

This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene\; however, their full-length nature is not known.

Gene names and symbols associated with XRN2

  • 5'-3' exoribonuclease 2 (xrn2) antibody
  • 5'-3' exoribonuclease 2 (XRN2) antibody
  • 5'-3' exoribonuclease 2, putative (TA11675) antibody
  • 5'-3' exoribonuclease 2 (LELG_04162) antibody
  • 5'-3' exoribonuclease 2 (AOR_1_874194) antibody
  • 5'-3' exoribonuclease 2 (PTRG_01514) antibody
  • 5'-3' exoribonuclease 2 (PTRG_10866) antibody
  • 5'-3' exoribonuclease 2 (Tsp_08094) antibody
  • 5'-3' exoribonuclease 2 S homeolog (xrn2.S) antibody
  • 5'-3' exoribonuclease 2 (Xrn2) antibody
  • exoribonuclease 2 (XRN2) antibody
  • AO090012000503 antibody
  • AtXRN2 antibody
  • DKFZp459J063 antibody
  • exoribonuclease 2 antibody
  • K16E1.2 antibody
  • K16E1_2 antibody
  • wu:fb38g12 antibody
  • wu:fj53d06 antibody
  • zgc:55717 antibody

Protein level used designations for XRN2

5'-3' exoribonuclease 2 , 5'-3' exoribonuclease 2-like , DHP protein , Dhm1-like protein (mouse homolog) , protein Dhm1

GENE ID SPECIES
321940 Danio rerio
458131 Pan troglodytes
477133 Canis lupus familiaris
517417 Bos taurus
700934 Macaca mulatta
733834 Xenopus (Silurana) tropicalis
3861687 Theileria annulata strain Ankara
5231754 Lodderomyces elongisporus NRRL YB-4239
5987983 Aspergillus oryzae RIB40
6338441 Pyrenophora tritici-repentis Pt-1C-BFP
6349178 Pyrenophora tritici-repentis Pt-1C-BFP
10906655 Trichinella spiralis
100031372 Monodelphis domestica
100049102 Xenopus laevis
100050094 Equus caballus
100173960 Pongo abelii
100353161 Oryctolagus cuniculus
100388181 Callithrix jacchus
100468930 Ailuropoda melanoleuca
100517201 Sus scrofa
100593111 Nomascus leucogenys
22803 Homo sapiens
24128 Mus musculus
362229 Rattus norvegicus
421236 Gallus gallus
834261 Arabidopsis thaliana
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