5'-Nucleotidase, Cytosolic II Proteins (NT5C2)

NT5C2 encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. Additionally we are shipping 5'-Nucleotidase, Cytosolic II Antibodies (61) and 5'-Nucleotidase, Cytosolic II Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NT5C2 22978 P49902
NT5C2 76952 Q3V1L4
NT5C2 100363253  
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Top 5'-Nucleotidase, Cytosolic II Proteins at antibodies-online.com

Showing 7 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human NT5C2 Protein. 100 μg 11 to 18 Days
$511.69
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Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
$553.85
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications 1 to 2 Days
$318.85
Details

NT5C2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

More Proteins for 5'-Nucleotidase, Cytosolic II (NT5C2) Interaction Partners

Human 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. Targeted sequencing of NT5C2 did not identify any missense variants associated with rs72846714 or wmEry-TGN/wmDNA-TG.

  2. Results uncover dynamic mechanisms of enzyme regulation targeted by chemotherapy resistance-driving NT5C2 mutations in relapsed acute lymphoblastic leukemia.

  3. intersubunit interaction forms structural basis of hyperactive NT5C2 in drug-resistant leukemia in which heterozygous NT5C2 mutation gave rise to hetero-tetramer mutant and WT proteins.

  4. NT5C2 mutations seem to have a broad clinical spectrum and should be sought in patients manifesting either as uncomplicated or complicated spastic paraplegia

  5. Using data from a large-scale genome-wide association study of schizophrenia, study identified several potentially functional variants relating to miRNA function with our top finding being a schizophrenia protective allele that disrupts miR-206s binding to NT5C2 thus leading to increased expression of this gene.

  6. acute lymphoblastic leukemia-specific mutations affect regulation of cN-II

  7. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  8. NT5C2 variant rs11191580 conferred susceptibility to schizophrenia and affected the clinical symptoms of schizophrenia in a South Chinese Han population.

  9. The aberrantly spliced NT5C2 showed substantial reduction in expression level in the in-vitro study, indicating marked instability of the mutant NT5C2 protein.

  10. Leukemia Relapse-Associated Mutation of NT5C2 Gene is Rare in de Novo Acute Leukemias and Solid Tumors.

  11. cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  12. Data indicate that type II cytosolic 5'-nucleotidase (cN-II) exerts a role in nucleotide and drug metabolism and regulating cell survival.

  13. Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations.

  14. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia

  15. results highlight the prominent role of relapse-specific mutations in NT5C2 as a mechanism of resistance to 6-Mercaptopurine and a genetic driver of relapse in acute lymphoblastic leukemia

  16. analysis of Drosophila and human 7-methyl GMP-specific nucleotidases

  17. Polymorphisms in the CYP17A1 and NT5C2 genes influence a reduction in both visceral and subcutaneous fat mass in Japanese women.

  18. seven high-resolution structures of human cN-II, including a ligand-free form and complexes with various substrates and effectors, were presented.

  19. cN-II has a role in protecting against progression of non-small cell lung cancer

  20. the expression level of cN-II mRNA might be a prognostic factor of high-risk MDS.

Mouse (Murine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. The results on muscles from the NT5C knockout mice contradict previous findings where AMP levels and AMPK activity were shown to be modulated by NT5C enzymes.

Cow (Bovine) 5'-Nucleotidase, Cytosolic II (NT5C2) interaction partners

  1. mutated three residues that mediate interaction in the first activation site (R144, N154, I152) and three in the second (F127, M436 and H428), and found that ApA and ADP interact with the same site, but the sites for ATP and BPG remain uncertain

5'-Nucleotidase, Cytosolic II (NT5C2) Protein Profile

Protein Summary

This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides.

Gene names and symbols associated with NT5C2

  • 5'-nucleotidase, cytosolic II (NT5C2)
  • 5'-nucleotidase, cytosolic II (nt5c2.L)
  • 5'-nucleotidase, cytosolic II (nt5c2)
  • 5'-nucleotidase, cytosolic IIa (nt5c2a)
  • 5'-nucleotidase, cytosolic II (Nt5c2)
  • 5'-nucleotidase, cytosolic II (surE2)
  • 2010002I23Rik protein
  • cN-II protein
  • CnII protein
  • ENSMUSG00000025039 protein
  • Gm9751 protein
  • Gmp protein
  • Nt5b protein
  • NT5C2 protein
  • Pnt5 protein
  • wu:fc36f11 protein
  • wu:fc45b10 protein

Protein level used designations for NT5C2

cytosolic 5'-nucleotidase II , cytosolic purine 5'-nucleotidase , 5'-nucleotidase, cytosolic II , fc36f11 , 5'-nucleotidase (purine), cytosolic type B , IMP-specific 5'-NT , purine 5' nucleotidase , 5'-nucleotidase cytosolic II , cytosolic IMP/GMP-specific 5'-nucleotidase , cytosolic purine 5'-nucleotidase-like

GENE ID SPECIES
477809 Canis lupus familiaris
444729 Xenopus laevis
548490 Xenopus (Silurana) tropicalis
714292 Macaca mulatta
324845 Danio rerio
22978 Homo sapiens
450706 Pan troglodytes
76952 Mus musculus
281951 Bos taurus
423871 Gallus gallus
100172749 Pongo abelii
5808749 Sorangium cellulosum So ce56
100363253 Rattus norvegicus
100402763 Callithrix jacchus
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