anti-7-Dehydrocholesterol Reductase (DHCR7) Antibodies

DHCR7 encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. Additionally we are shipping DHCR7 Kits (7) and DHCR7 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DHCR7 13360 O88455
DHCR7 64191 Q9Z2Z8
DHCR7 1717 Q9UBM7
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Top anti-DHCR7 Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0. 1% Triton X-100 permeabilized HeLa (human cervical epithelial adenocarcinoma cell line) cells labeling Pdx1 with antibody at 1/25 dilution, followed by Dylight 488-conjugated goat anti-rabbit IgG (NK179883) secondary antibody at 1/200 dilution (green). Immunofluorescence image showing cytoplasm staining on HeLa cell line. Cytoplasmic actin is detected with Dylight 554 Phalloidin (PD18466410) at 1/100 dilution (red). The nuclear counter stain is DAPI (blue). Western Blot at 1:2000 dilution Lane 1: HepG2 whole cell lysate Lane 2: Li-7 whole cell lysate Lane 3: U-87 MG whole cell lysate Lane 4: human testis lysate Lane 5: mouse testis lysate Lysates/proteins at 20 ug per lane. 400 μL 2 to 3 Days
$515.63
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Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cells, using DHCR7 antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Human HL-60 cell lysates probed with Anti-DHCR7 Polyclonal Antibody, Unconjugated  at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody -HRP) at 1:10000 for 90 min at 37˚C. 100 μL 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated WB DHCR7 MaxPab rabbit polyclonal antibody. Western Blot analysis of DHCR7 expression in rat brain. DHCR7 MaxPab rabbit polyclonal antibody. Western Blot analysis of DHCR7 expression in mouse testis. 100 μg 11 to 12 Days
$350.67
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit Cy3 IF (p)   100 μL 14 to 21 Days
$416.90
Details
Human Rabbit FITC IF (p)   100 μL 14 to 21 Days
$416.90
Details

More Antibodies against DHCR7 Interaction Partners

Xenopus laevis 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog are co-expressed during midline development in Xenopus embryos.

  2. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system

Arabidopsis thaliana 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles

Mouse (Murine) 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Dhcr7 heterozygous mice made fewer ultrasonic vocalizations. Increases of 7-DHC and expression of the serotonin transporter were observed in the compound mutant mice.

  2. Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh), and bone morphogenetic protein-2 (Bmp2) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol.

  3. significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs

  4. data indicate an underlying dysfunction of the 5-HT2A receptors in Dhcr7-HET mice that warrants further investigation to establish how this may relate to behavioral disturbances in human patients carrying Dhcr7 mutations

  5. conclude that cytochrome P450 reductase is not involved in 7-dehydrocholesterol reductase activity

  6. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.

  7. Immunohistochemical analyses have revealed a 306% increase in the area of 5-HT immunoreactivity (5-HT IR) in the hindbrains of mutant (Dhcr7-/-) mice as compared to age-matched wild type animals.

  8. Of the 12,000 genes analyzed, 91 were upregulated and 98 were downregulated in the Dhcr7-/- hindbrains when compared to wild-type animals.

  9. CNS defects caused by Dhcr7 null likely play a major role in the lethal pathogenesis of Dhcr7-/- mice, with the peripheral organs contributing the morbidity

  10. A viable mouse model for Smith-Lemli-Opitz syndrome has recently been developed, and cholesterol metabolism in this model with emphasis on changes during the first few weeks of postnatal development, is characterized.

  11. Data show that in vitro down regulation of NRIF expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and 7-dehydrocholesterol reductase.

  12. down-regulation of Dhcr7 altered expression of multiple molecules that play critical roles in intracellular signaling or vesicular transport or are inserted into membrane rafts, and down-regulated several critical genes involved in lipid biosynthesis

  13. Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome

Human 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. The study detected Smith-Lemli-Opitz syndrome (SLOS) mutations in only 0.7% of stillbirths. This does not support a strong association between unrecognized DHCR7 mutations and stillbirth.

  2. A genetic risk score (GRS) was calculated based on 3 genetic variants [i.e., 7-dehydrocholesterol reductase (DHCR7) rs12785878, cytochrome P450 2R1 (CYP2R1) rs10741657 and group-specific component globulin (GC) rs2282679] related to circulating vitamin D levels. We found a significant interaction between dietary fat intake and vitamin D GRS on 2-y changes in whole-body bone mineral density.

  3. DHCR7 mutations for 2 female fetuses with Smith-Lemli- Opitz syndrome and metatarsal bony syndactyly were analyzed.

  4. DHCR7 polymorphism is associated with rheumatoid arthritis.

  5. SNPs rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) may work in conjunction with each other to amplify individual genotyping impacts on serum cholesterol responses to dairy consumption.

  6. aim of this study was to determine the association between single nucleotide polymorphisms (SNPs) of PNPLA3 (rs738409), COX-2 (rs689465) and DHCR7 (rs12785878) and advanced liver fibrosis in Thai patients

  7. pathogenic mutations in DHCR7 protein are located either within the transmembrane region or are near the ligand-binding site, and are highly conserved among species.

  8. The DHCR7 polymorphism may be a pre-treatment predictive marker for response to PEG-IFN-based therapy in chronic HCV genotype 1 infection.

  9. phosphorylation modulates DHCR7 activity in cells, and contributes to the overall synthesis of cholesterol, and probably vitamin D

  10. Allelic variations in CYP2R1 and GC affect vitamin D levels, but variant alleles on VDR and DHCR7 were not correlated with vitamin D deficiency.

  11. Genetic variations in ABCG5, CYP7A1, and DHCR7 may contribute to differing responses of serum cholesterol to dairy intake among healthy adults.

  12. Review: DHCR7 activity should be considered during drug development and prenatal toxicity assessment.

  13. In this study, we demonstrate that the prevalent c.964-1G>C Dhcr7 mutation perturbs SMO cilia localization and SHH pathway activation as a consequence of reduced cholesterol biosynthesis

  14. these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis.

  15. The aim of this study was to investigate the association of three polymorphisms in the GC gene (rs7041 and rs4588) and CYP2R1 gene (rs10741657) on 25-(OH) VD serum concentration among Jordanians.

  16. This study shows that Smith-Lemli-Opitz Syndrome patients who are heterozygous/homozygous for one pathogenic mutation and only one parent carrying that mutation are candidates for DHCR7 gene (partial) deletions.

  17. Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations

  18. physical and functional interaction between DHCR24 and DHCR7

  19. In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7)

  20. rs3829251 (DHCR7) influenced progression of subclinical atherosclerosis in a manner dependent on type 2 diabetes status but independent of 25(OH)D levels. The SNP modulates DHCR7 mRNA levels in aortic adventitia.

DHCR7 Antigen Profile

Protein Summary

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS)\; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with DHCR7

  • 7-dehydrocholesterol reductase (DHCR7) antibody
  • 7-dehydrocholesterol reductase (dhcr7) antibody
  • 7-dehydrocholesterol reductase L homeolog (dhcr7.L) antibody
  • Ergosterol biosynthesis ERG4/ERG24 family (DWF5) antibody
  • 7-dehydrocholesterol reductase (PAAG_04766) antibody
  • 7-dehydrocholesterol reductase (PITG_13128) antibody
  • 7-dehydrocholesterol reductase (VDBG_05423) antibody
  • 7-dehydrocholesterol reductase (MGYG_00712) antibody
  • 7-dehydrocholesterol reductase (TERG_00580) antibody
  • 7-dehydrocholesterol reductase (Dhcr7) antibody
  • 7-Dhcr antibody
  • 7-STEROL DELTA7 REDUCTASE antibody
  • 7RED antibody
  • AA409147 antibody
  • DELTA5 antibody
  • DKFZp468C1911 antibody
  • DWARF 5 antibody
  • F11F12.21 antibody
  • F11F12_21 antibody
  • LE antibody
  • LEPIDA antibody
  • MGC64361 antibody
  • PA antibody
  • PARVA antibody
  • SLOS antibody
  • ST7R antibody
  • STEROL DELTA7 REDUCTASE antibody
  • xdhcr7 antibody

Protein level used designations for DHCR7

7-DHC reductase , sterol Delta(7)-reductase , 7-dehydrocholesterol reductase , delta-7-dehydrocholesterol reductase , putative sterol reductase SR-2 , sterol delta-7-reductase

GENE ID SPECIES
100061433 Equus caballus
378446 Danio rerio
380248 Xenopus laevis
394844 Xenopus (Silurana) tropicalis
841465 Arabidopsis thaliana
9096525 Paracoccidioides sp. 'lutzii' Pb01
9472946 Phytophthora infestans T30-4
9531294 Verticillium alfalfae VaMs.102
10031944 Arthroderma gypseum CBS 118893
10374056 Trichophyton rubrum CBS 118892
100172090 Pongo abelii
13360 Mus musculus
64191 Rattus norvegicus
1717 Homo sapiens
422982 Gallus gallus
483675 Canis lupus familiaris
514745 Bos taurus
379273 Xenopus laevis
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