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Within placental villi, ADAM28 mRNA levels were highest in HLA-G(+) column trophoblasts, and consistent with this, ADAM28 was preferentially localized to HLA-G(+) trophoblasts within distal anchoring columns and decidual tissue.
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There is a relationship between the serum level of ADAM28 and the degree of the colonic cancer clinical stage.
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miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28.
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The data demonstrate that ADAM28 is expressed by epithelial cells of several normal organs, and suggest that ADAM28 plays a role in cell survival by suppression of C1q-induced cytotoxicity in bronchial epithelial cells.
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ADAM28 is overexpressed in primary human prostate tumor biopsies, and it promotes human prostate cancer cell proliferation and migration.
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The results of this study suggest that these proteins play important roles in pulmonary inflammatory reactions elicited against etiological viral agents.
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Src is an inducer of ADAM28 gene expression through the MEK/extracellular signal-regulated kinase and PI3K/mammalian target of rapamycin pathways.
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IL-1beta-induced MMP-13 expression and changes in cell proliferation and apoptosis in alpha7(+)hSMSC-OB cells are regulated by ADAM-28.
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Sequence analysis of ADAM28 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21
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The change of ADAM28 and IGFBP-3 gene expression is present in the normal tissue in overweight/obese patients with colorectal cancer only, and the observed variability of ADAM28 and IGFBP-3 expression may be an initial process of cancer proliferation
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High ADAM28 expression is associated with B-Cell Chronic Lymphocytic Leukemia.
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Human ADAM28 expression levels were positively correlated with parameters of the metabolic syndrome.
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ADAM28 cleaves and inactivates proapoptotic VWF in carcinoma cells and enhances lung metastasis probably by promoting carcinoma cell survival within the blood vessels.
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Study shows using proteomics that ADAM28 may be used as a possible biomarker of bladder cancer.
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ADAM28 showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer.
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ADAM28 might actively participate in manipulating the proliferation, differentiation, and apoptosis of human dental pulp stem cells (HDPSCs).
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It plays a role in cancer cell proliferation, invasion and metastasis. (review)
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These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF(165)-induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF(165) complex.
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High ADAM28 in serum is associated with non-small-cell lung cancers.
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Upregulation of ADAM28 is associated with asbestos-related lung adenocarcinomas.
