anti-ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 15 (ADAMTS15) Antibodies

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 15 (ADAMTS15) interaction partners

1. spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts15 in mice.

2. Results show that ADAMTS15 and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development

3. these data suggest a role for ADAMTS15 in a wide range of biological processes that are potentially mediated through the processing of versican.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 15 (ADAMTS15) interaction partners

1. ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas.

2. ADAMTS15 expression is significantly upregulated in human masticatory mucosa during wound healing

3. ADAMTS15 is a candidate gene for intracranial aneurysms

4. ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4.

5. Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation.

6. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene

7. negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer

8. ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma

9. ADAMTS15 may be target of inactivating mutations in human cancer.