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ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies (165) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (9) and many more products for this protein.
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Human ADAMTS4 ELISA Kit for Sandwich ELISA - ABIN649162
Zha, Chen, Xu, Zhang, Li, Zhao, Cui: Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. in Clinical research in cardiology : official journal of the German Cardiac Society 2010
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Moncada-Pazos, Obaya, Viloria, López-Otín, Cal: The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. in Journal of molecular medicine (Berlin, Germany) 2011
Show all 5 Pubmed References
the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues
Results show that ADAMTS15 (show ADAMTS15 ELISA Kits) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
aggrecan (show ACAN ELISA Kits) and brevican (show BCAN ELISA Kits) proteolysis is compensated in Adamts4-/- or Adamts5 (show ADAMTS5 ELISA Kits)-/- mice by ADAMTS (show ADAMTS1 ELISA Kits) proteoglycanase (show MMP3 ELISA Kits) family members but a threshold of versican (show Vcan ELISA Kits) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 ELISA Kits) proteoglycanase (show MMP3 ELISA Kits) during spinal cord injury
ADAMTS4 has roles in melanoma growth and angiogenesis in mice
The serine protease (show F2 ELISA Kits) tissue plasminogen activator (tPA (show PLAT ELISA Kits)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (show ADAMTS5 ELISA Kits), were identified as Reelin (show RELN ELISA Kits) cleaving enzymes.
ADAMTS-4 cleaves Reelin (show RELN ELISA Kits) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (show LSP1 ELISA Kits) cleaves the N-t site only, while p75 (show NGFR ELISA Kits) cleaves both sites.
Data demonstrate that Adamts1 (show ADAMTS1 ELISA Kits) and Adamts4 play redundant and essential roles in perinatal kidney development.
Drastic down-regulation of Adamts4 observed at both E16 (show SLC7A5 ELISA Kits) and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.
proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue
ADAMTS1 (show ADAMTS1 ELISA Kits), ADAMTS4, and ADAMTS5 (show ADAMTS5 ELISA Kits) are expressed in patterns that relate to the expression pattern of versican (show Vcan ELISA Kits) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.
ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.
Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (show FBLN2 ELISA Kits) is a better substrate for ADAMTS-5 (show ADAMTS5 ELISA Kits) than it is for ADAMTS-4. Fibulin-2 (show FBLN2 ELISA Kits) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
ADAMTS4 and ADAMTS15 (show ADAMTS15 ELISA Kits) were upregulated in symptomatic uterine leiomyomas.
The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.
Single Nucleotide Variants of Candidate Genes in Aggrecan (show ACAN ELISA Kits) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Results show that ADAMTS4 mRNA is the target of mir (show MLXIP ELISA Kits)-1268a and its expression might be modified by MIR (show MLXIP ELISA Kits)-1268a rs28599926 polymorphism in hepatocellular carcinoma.
we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 (show ADAMTS5 ELISA Kits) genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 (show ADAMTS5 ELISA Kits) genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (show ADAMTS5 ELISA Kits) (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing
ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .
in degenerative intervertebral discs, IL1b (show IL1B ELISA Kits) upregulates NFkB, MMP13 (show MMP13 ELISA Kits) and ADAMTS4
ADAMTS4 participates in the regulation of muscle development in cattle.
aggrecanase activity (a) is responsible for early TNFalpha (show TNF ELISA Kits)-dependent aggrecan (show ACAN ELISA Kits) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
ADAMTS4 and ADAMTS5 (show ADAMTS5 ELISA Kits) are inhibited by alpha2-macroglobulin (show A2M ELISA Kits)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (show ADAMTS5 ELISA Kits)
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
A disintegrin and metalloproteinase with thrombospondin motifs 4
, ADAM-TS 4
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
, a disintegrin and metallopeptidase with thrombospondin motifs 4
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
, ADAM metallopeptidase with thrombospondin type 1 motif, 4
, A disintegrin and metalloproteinase with thrombospondin motifs 4-like
, disintegrin and metalloproteinase with thrombospondin motifs 2
, a disintegrin and metalloproteinase with thrombospondin motifs 4