ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) ELISA Kits

ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies (146) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ADAMTS4 240913 Q8BNJ2
ADAMTS4 9507 O75173
ADAMTS4 66015 Q9ESP7
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Top ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 ELISA Kits at antibodies-online.com

Showing 10 out of 46 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.115 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days
$736.84
Details
Rat 0.056 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$800.00
Details
Rabbit 12.1 pg/mL 31.2 pg/mL - 2000 pg/mL 96 Tests Log in to see 13 to 16 Days
$800.00
Details
Mouse 0.78 ng/mL 3.12-200 ng/mL   96 Tests Log in to see 15 to 18 Days
$910.56
Details
Cow 0.78 ng/mL n/a   96 Tests Log in to see 15 to 18 Days
$1,026.67
Details
Goat
  96 Tests Log in to see 15 to 18 Days
$707.14
Details
Dog
  96 Tests Log in to see 15 to 18 Days
$707.14
Details
Please inquire
1 kit Log in to see 2 to 3 Days
$594.10
Details
Chicken 1.875 pg/mL 3.125 pg/mL - 200 pg/mL   96 Tests Log in to see 11 to 18 Days
$731.99
Details
Pig 37.5 pg/mL 62.5 pg/mL - 4000 pg/mL   96 Tests Log in to see 11 to 18 Days
$731.99
Details

Top referenced ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 ELISA Kits

  1. Human ADAMTS4 ELISA Kit for Sandwich ELISA - ABIN649162 : Zha, Chen, Xu, Zhang, Li, Zhao, Cui: Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome. in Clinical research in cardiology : official journal of the German Cardiac Society 2010 (PubMed)
    Show all 8 Pubmed References

  2. ABIN1882391 : Moncada-Pazos, Obaya, Viloria, López-Otín, Cal: The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. in Journal of molecular medicine (Berlin, Germany) 2011 (PubMed)
    Show all 5 Pubmed References

  3. Human ADAMTS4 ELISA Kit - ABIN454126 : Zha, Chen, Xu, Li, Zhao, Cui: ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. in Biomedicine & pharmacotherapy 2010 (PubMed)

  4. Human ADAMTS4 ELISA Kit for Sandwich ELISA - ABIN366270 : Mao, Wu, Zhang, Zhang, Liao, Li, Kang: MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1β-Induced Catabolism in Human Articular Chondrocytes. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018 (PubMed)

More ELISA Kits for ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth.

  2. This study demonstrated that ADAMTS-4 is a new marker of mature oligodendrocytes contributing to the myelination processes and thus to the control of motor capacities.

  3. results demonstrate for the first time that ADAMTS4 contributes to diet induced atherosclerosis in ApoE(-/-) mice

  4. the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues

  5. Results show that ADAMTS15 and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development

  6. aggrecan and brevican proteolysis is compensated in Adamts4-/- or Adamts5-/- mice by ADAMTS proteoglycanase family members but a threshold of versican proteolysis is sensitive to the loss of a single ADAMTS proteoglycanase during spinal cord injury

  7. ADAMTS4 has roles in melanoma growth and angiogenesis in mice

  8. The serine protease tissue plasminogen activator (tPA) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5, were identified as Reelin cleaving enzymes.

  9. ADAMTS-4 cleaves Reelin in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 cleaves the N-t site only, while p75 cleaves both sites.

  10. Data demonstrate that Adamts1 and Adamts4 play redundant and essential roles in perinatal kidney development.

  11. Drastic down-regulation of Adamts4 observed at both E16 and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.

  12. proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue

  13. ADAMTS1, ADAMTS4, and ADAMTS5 are expressed in patterns that relate to the expression pattern of versican in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.

  14. ADAMTS-5 is entirely responsible for cleavage in the interglobular domain, but cleavage in the chondroitin sulfate-rich region may be driven by ADAMTS-4

  15. comparison of aggrecan loss with aggrecan processing in mice with single and double deletions of ADAMTS-4 and -5 activity (Deltacat)

  16. Deletion of ADAMTS-4/5 provided significant protection against proteoglycan degradation ex vivo and decreased the severity of murine osteoarthritis

  17. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9.

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. The lower levels of ADAMTS4 in the primary ovarian insufficiency group, when compared with the idiopathic hypogonadotropic hypogonadism patients pointed out that even limited hormone secretion and ovulation in the POI group, may have protective effect on cardiovascular system. The higher levels of ADAMTS4 and lipid accumulation in the IHH group demonstrated the increased risk of these patients for cardiovascular disease.

  2. ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group.

  3. ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC and ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo.

  4. ADAMTS4 expression was upregulated during carotid atherosclerotic plaque development. Serum levels of ADAMTS4 were associated with increased plaque vulnerability in both symptomatic and asymptomatic patients with carotid artery stenosis.

  5. methylation status of the ADAMTS4 gene is altered in patellar tendinopathy

  6. HipHop-based pharmacophore modeling and virtual screening of the Maybridge database to identify novel ADAMTS-4 inhibitors. These novel lead compounds act as potent and specific inhibitors for the ADAMTS-4 enzyme and could have therapeutic potential in the treatment of OA.

  7. ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.

  8. Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.

  9. ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas.

  10. The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.

  11. Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  12. Results show that ADAMTS4 mRNA is the target of mir-1268a and its expression might be modified by MIR-1268a rs28599926 polymorphism in hepatocellular carcinoma.

  13. we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.

  14. ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing

  15. ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .

  16. in degenerative intervertebral discs, IL1b upregulates NFkB, MMP13 and ADAMTS4

  17. progesterone acts via the progesterone receptor to modulate ADAMTS 1 and 4 levels in ovarian cancer cell lines.

  18. ADAMTS4 may be responsible for the pathogenesis of atherosclerosis. ADAMTS4 serum levels were also higher in diabetic cases. There is an association between ADAMTS4 and TGFb1 serum levels in the progression of atherosclerosis in coronary artery disease.

  19. Evaluate ADAMTS-4 and ADAMTS-5 immunohistochemical expression in human TMJ discs from patients affected by internal derangement.

  20. These data demonstrate that the antibody is specific to ADAMTS4 and ADAMTS5 and inhibits their aggrecanase activity at molecular and cellular levels.

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS4 participates in the regulation of muscle development in cattle.

  2. aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  3. ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin

  4. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Antigen Profile

Antigen Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Gene names and symbols associated with ADAMTS4

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4) antibody
  • ADAM metallopeptidase with thrombospondin type 1 motif 4 (Adamts4) antibody
  • 3830423K05 antibody
  • ADAM-TS4 antibody
  • ADAMTS-2 antibody
  • ADAMTS-4 antibody
  • ADAMTS4 antibody
  • ADMP-1 antibody
  • mKIAA0688 antibody

Protein level used designations for ADAMTS4

A disintegrin and metalloproteinase with thrombospondin motifs 4 , ADAM-TS 4 , ADAMTS-4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 , aggrecanase-1 , ADAM-TS4 , Aggrecanase , a disintegrin and metallopeptidase with thrombospondin motifs 4 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 , ADMP-1 , ADAM metallopeptidase with thrombospondin type 1 motif, 4 , A disintegrin and metalloproteinase with thrombospondin motifs 4-like , disintegrin and metalloproteinase with thrombospondin motifs 2 , a disintegrin and metalloproteinase with thrombospondin motifs 4

GENE ID SPECIES
240913 Mus musculus
9507 Homo sapiens
66015 Rattus norvegicus
286806 Bos taurus
457453 Pan troglodytes
488651 Canis lupus familiaris
719927 Macaca mulatta
100033914 Equus caballus
100409334 Callithrix jacchus
100008765 Oryctolagus cuniculus
100482466 Ailuropoda melanoleuca
100606067 Nomascus leucogenys
100712995 Cavia porcellus
101106565 Ovis aries
100461178 Pongo abelii
100858999 Gallus gallus
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