Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies (165) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Kits (42) and many more products for this protein.
Showing 8 out of 9 products:
the reduction of ADAMTS-4 activity during the progression of ALS pathology may be an adaptive change to mitigate its neurodegenerative impact in CNS tissues
Results show that ADAMTS15 (show ADAMTS15 Proteins) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
aggrecan (show ACAN Proteins) and brevican (show BCAN Proteins) proteolysis is compensated in Adamts4-/- or Adamts5 (show ADAMTS5 Proteins)-/- mice by ADAMTS (show ADAMTS1 Proteins) proteoglycanase (show MMP3 Proteins) family members but a threshold of versican (show Vcan Proteins) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Proteins) proteoglycanase (show MMP3 Proteins) during spinal cord injury
ADAMTS4 has roles in melanoma growth and angiogenesis in mice
The serine protease (show F2 Proteins) tissue plasminogen activator (tPA (show PLAT Proteins)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Proteins), were identified as Reelin (show RELN Proteins) cleaving enzymes.
ADAMTS-4 cleaves Reelin (show RELN Proteins) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (show LSP1 Proteins) cleaves the N-t site only, while p75 (show NGFR Proteins) cleaves both sites.
Data demonstrate that Adamts1 (show ADAMTS1 Proteins) and Adamts4 play redundant and essential roles in perinatal kidney development.
Drastic down-regulation of Adamts4 observed at both E16 and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.
proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue
ADAMTS1 (show ADAMTS1 Proteins), ADAMTS4, and ADAMTS5 (show ADAMTS5 Proteins) are expressed in patterns that relate to the expression pattern of versican (show Vcan Proteins) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.
ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.
Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 (show FBLN2 Proteins) is a better substrate for ADAMTS-5 (show ADAMTS5 Proteins) than it is for ADAMTS-4. Fibulin-2 (show FBLN2 Proteins) degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
ADAMTS4 and ADAMTS15 (show ADAMTS15 Proteins) were upregulated in symptomatic uterine leiomyomas.
The SNP rs4233367 in the exon of ADAMTS-4 gene may be associated with lumbar disc degeneration.
Single Nucleotide Variants of Candidate Genes in Aggrecan (show ACAN Proteins) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Results show that ADAMTS4 mRNA is the target of mir (show MLXIP Proteins)-1268a and its expression might be modified by MIR (show MLXIP Proteins)-1268a rs28599926 polymorphism in hepatocellular carcinoma.
we investigated whether important polymorphisms in the ADAMTS4 and ADAMTS5 (show ADAMTS5 Proteins) genes affect osteoarthritis (OA) susceptibility. ADAMTS4 and ADAMTS5 (show ADAMTS5 Proteins) genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (rs4233367 and rs11807350) and ADAMTS5 (show ADAMTS5 Proteins) (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing
ADAMTS4 may have a role in the pathogenesis by causing increased oxidative and inflammatory environment in preterm premature rupture of membranes .
in degenerative intervertebral discs, IL1b (show IL1B Proteins) upregulates NFkB, MMP13 (show MMP13 Proteins) and ADAMTS4
ADAMTS4 participates in the regulation of muscle development in cattle.
aggrecanase activity (a) is responsible for early TNFalpha (show TNF Proteins)-dependent aggrecan (show ACAN Proteins) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
ADAMTS4 and ADAMTS5 (show ADAMTS5 Proteins) are inhibited by alpha2-macroglobulin (show A2M Proteins)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Proteins)
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
A disintegrin and metalloproteinase with thrombospondin motifs 4
, ADAM-TS 4
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
, a disintegrin and metallopeptidase with thrombospondin motifs 4
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
, ADAM metallopeptidase with thrombospondin type 1 motif, 4
, A disintegrin and metalloproteinase with thrombospondin motifs 4-like
, disintegrin and metalloproteinase with thrombospondin motifs 2
, a disintegrin and metalloproteinase with thrombospondin motifs 4