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ADAMTS12 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS12 Antibodies (27) and ADAMTS12 Kits (18) and many more products for this protein.
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ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]
ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis.
ADAMTS-12 plays protective roles acting against the development of asthma phenotype upon experimental allergen exposure, interfering with immunological processes leading to inflammation and airway hyperresponsiveness.
Results define a break point in mouse chromosome 15qA1 to a 27-kb region containing ADAMTS12, and show that the break is likely between exons 2 and 3 of ADAMTS12.
Absence of Adamts-12 is associated with the increase in angiogenic response and tumor invasion into host tissue.
ADAMTS12 expression is significantly upregulated in human masticatory mucosa during wound healing
Decreased levels of ADAMTS-12 were found to be associated with intrahepatic cholestasis of pregnancy.
Our results suggest that ADAMTS12 may be a susceptibility gene for RA development.
statistically significant increase in mRNA expression of ADAMTS-7 (show ADAMTS7 Proteins) and ADAMTS-12 was observed in the endplate cells in degenerative discs compared with nondegenerative discs
The data supported the hypothesis that genetic variations in ADAMTS12 influence the risk of schizophrenia.
expression of ADAMTS12 in colorectal cancer stroma plays an important role in inhibiting tumor development
This study identifies a novel biological role for ADAMTS-12, and highlights the importance and complexity of its non-proteolytic domain(s) pertaining to its function.
ADAMTS-12 is a new COMP (show COMP Proteins)-interacting and -degrading enzyme and thus may play an important role in the COMP (show COMP Proteins) degradation in the initiation and progression of arthritis
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
ADAM metallopeptidase with thrombospondin type 1 motif, 12
, adam-ts 12
, A disintegrin and metalloproteinase with thrombospondin motifs 12
, ADAM-TS 12
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
, a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 12
, metalloprotease disintegrin 12
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12