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ADAMTS8 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS8 Antibodies (63) and ADAMTS8 Kits (23) and many more products for this protein.
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This study demonstrated that Cortical fast-spiking parvalbumin (show PVALB Proteins) interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.
ADAMTS-4 (show ADAMTS4 Proteins) expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
This study showed that ADAMTS1 (show ADAMTS1 Proteins), 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)
ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer.
Study uncovers the tumor suppressive function of ADAMTS8 and its frequent methylation in certain tumors could be developed as a potential biomarker.
ADAMTS 8, CCL23 (show CCL23 Proteins), and TNFSF15 (show TNFSF15 Proteins) are implicated in anti-angiogenic activities
Ability of ADAMTS-8 to cleave aggrecan (show ACAN Proteins) at aggrecanase (show ADAMTS4 Proteins)-susceptible Glu373-Ala374 peptide bond. Presence of ADAMTS-8 mRNA transcripts in normal and osteoarthritic human cartilage. (ADAMTS-8)
Downdownregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease.
ADAMTS8 and ADAMTS15 (show ADAMTS15 Proteins) have emerged as novel predictors of survival in patients with breast carcinoma
Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% brain tumours. A role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis.
ADAMTS-4 (show ADAMTS4 Proteins) and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
ADAM metallopeptidase with thrombospondin type 1 motif, 8
, A disintegrin and metalloproteinase with thrombospondin motifs 8
, ADAM-TS 8
, ADAMTS-8 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2)
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8