ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 Proteins (ADAMTS8)

ADAMTS8 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAMTS8 Antibodies (63) and ADAMTS8 Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAMTS8 30806 P57110
ADAMTS8 11095 Q9UP79
Rat ADAMTS8 ADAMTS8 300475  
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Top ADAMTS8 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$672.00
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Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$625.39
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ADAMTS8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
, ,

More Proteins for ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8) Interaction Partners

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8) interaction partners

  1. This study demonstrated that Cortical fast-spiking parvalbumin (show PVALB Proteins) interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.

  2. ADAMTS-4 (show ADAMTS4 Proteins) expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8) interaction partners

  1. This study showed that ADAMTS1 (show ADAMTS1 Proteins), 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)

  2. ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer.

  3. Study uncovers the tumor suppressive function of ADAMTS8 and its frequent methylation in certain tumors could be developed as a potential biomarker.

  4. ADAMTS 8, CCL23 (show CCL23 Proteins), and TNFSF15 (show TNFSF15 Proteins) are implicated in anti-angiogenic activities

  5. Ability of ADAMTS-8 to cleave aggrecan (show ACAN Proteins) at aggrecanase (show ADAMTS4 Proteins)-susceptible Glu373-Ala374 peptide bond. Presence of ADAMTS-8 mRNA transcripts in normal and osteoarthritic human cartilage. (ADAMTS-8)

  6. Downdownregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease.

  7. ADAMTS8 and ADAMTS15 (show ADAMTS15 Proteins) have emerged as novel predictors of survival in patients with breast carcinoma

  8. Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% brain tumours. A role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis.

  9. ADAMTS-4 (show ADAMTS4 Proteins) and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques

ADAMTS8 Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

Gene names and symbols associated with ADAMTS8

  • ADAM metallopeptidase with thrombospondin type 1 motif 8 (ADAMTS8)
  • ADAM metallopeptidase with thrombospondin type 1 motif 8 (adamts8)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ADAMTS8)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 8 (Adamts8)
  • ADAM-TS8 protein
  • ADAMTS8 protein
  • METH-2 protein
  • METH2 protein

Protein level used designations for ADAMTS8

ADAM metallopeptidase with thrombospondin type 1 motif, 8 , A disintegrin and metalloproteinase with thrombospondin motifs 8 , ADAM-TS 8 , ADAM-TS8 , ADAMTS-8 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 , ADAMTS-8 , METH-2 , METH-8 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8

GENE ID SPECIES
466852 Pan troglodytes
718962 Macaca mulatta
100076383 Ornithorhynchus anatinus
100387160 Callithrix jacchus
100456851 Pongo abelii
100469807 Ailuropoda melanoleuca
100497759 Xenopus (Silurana) tropicalis
100557571 Anolis carolinensis
30806 Mus musculus
11095 Homo sapiens
512544 Bos taurus
769222 Gallus gallus
100684302 Canis lupus familiaris
300475 Rattus norvegicus
101120031 Ovis aries
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