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The protein encoded by ARFGAP3 is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. Additionally we are shipping ARFGAP3 Antibodies (87) and ARFGAP3 Proteins (5) and many more products for this protein.
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We suggest a model in which ArfGAP3 regulates Golgi association of GGA clathrin adaptors.
our results suggest that ARFGAP3 is a novel androgen-regulated gene that can promote prostate cancer cell proliferation and migration in collaboration with paxillin.
human ARFGAP2 and ARFGAP3 are associated with COP-I-coated vesicles and function in COP I traffic
Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking
ArfGAP1, ArfGAP2, and ArfGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport.
ArfGAP3 interacts with RIBEYE in an NAD(H)-dependent manner.
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
ADP-ribosylation factor GTPase activating protein 1
, ADP-ribosylation factor GTPase-activating protein 3
, ARF GAP 3
, ADP ribosylation factor GTPase activating protein 3 S homeolog
, ADP-ribosylation factor GTPase activating protein 3