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ARLTS1 gene mutations can be considered as a potential predisposing factor in familial hematological malignancies
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A statistically significant (p = 0.0037) decrease of ARLTS1 expression in prostate cancer cases was detected.
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the important role of ARLTS1 Cys148Arg variant as a contributor in prostate cancer predisposition
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A significantly increased risk was observed for young ovarian cancer patients with ARLTS1 Cys148Arg variant.
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The role of the allelic variants in ARLTS1, RAD51 and MDM2 acting in the tumor suppressor, DNA repair and p53 pathways as risk factors for familial breast cancer in 147 patients displaying characteristics of familial disease, was investigated.
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A novel tumor suppressor gene [ARLTS1 (ADP-ribosylation factor-like tumor suppressor gene 1)]is found to be altered in human carcinogenesis. It is located in Chromosome 13q14.3.
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A genetic variant of ARLTS1 predisposes patients to familial cancer.
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the G446A in ARLTS1 gene is probably not associated with an increased risk of sporadic breast cancer, prostate cancer, melanoma, thyroid papillary cancer or laryngeal cancer
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The study does not support the postulate that variants of ARLTS1 influence the risk of chronic lymphocytic leukemia(CLL).
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While ARLTS1 Trp149Stop did not influence melanoma risk (OR = 0.83, 95% CI = 0.37-1.88, p = 0.65), Cys148Arg revealed a statistically significant association with an increased risk for heterozygous carriers (OR = 1.43, 95% CI = 1.05-1.95, p = 0.02)
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we found no association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia
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Cysteine148Arginine variant is associated with a moderately increased risk of colorectal cancer, both in sporadic and familial cases.
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650 transcripts expressed after restoration of ARLTS1 expression were identified in A549 cells, suggesting that pathways involved in cell survival, proliferation, signaling, and development mediate the effects of wild-type ARLTS1 in lung cancer.
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ARLTS1 germline variants are not associated with breast, prostate, and colorectal cancer
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Data show a significantly increased risk of familial OC for ARLTS1 Cys148Arg variant, which indicate that ARLTS1 may play a role in familial ovarian cancer.
