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The protein encoded by ARL5B belongs to the ARF family of GTP-binding proteins. Additionally we are shipping ADP-Ribosylation Factor-Like 5B Proteins (6) and many more products for this protein.
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Depletion of either Arl5b or AP4 (show REPIN1 Antibodies) results in the accumulation of APP (show APP Antibodies).
Arl5b is a trans-golgi-network-localised small G protein (show RAC2 Antibodies) that plays a key role in regulating transport along the endosome-trans-golgi network pathway
Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery.
ARL8 contains six exons and five introns, and encodes a 179 amino acid protein that shares homology to the other ARL proteins.
Our results, therefore, suggest that Arl5B is a negative regulator for MDA5 (show IFIH1 Antibodies).
The expression pattern of the mouse ortholog Arl8 revealed differential tissue expression and an alternate transcript was seen in brain that was age-dependent.
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs\; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.
ADP-ribosylation factor-like 8
, ADP-ribosylation factor-like 5B
, ADP-ribosylation factor-like protein 5B
, ADP-ribosylation factor-like protein 8
, ADP-ribosylation-like factor 8