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Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase.
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This supports the notion that de novo mutations in ALS2CL are extremely rare in schizophrenia
Data provide further support that ALS2CL, EPHA3 (show EPHA3 Antibodies), and CMYA1 (show XIRP1 Antibodies) are bona-fide tumor-suppressor genes and contribute to the tumorigenesis of HNSCC.
These results suggest that amyotrophic lateral sclerosis 2 C-terminal like (ALS2CL), a novel ALS2 (show ALS2 Antibodies) homologue, modulates Rab5 (show RAB5A Antibodies)-mediated endosome dynamics in HeLa cells.
ALS2CL is a novel ALS2 (show ALS2 Antibodies)-interacting protein implicated in ALS2 (show ALS2 Antibodies)-mediated endosome dynamics.
Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity).
ALS2 C-terminal-like protein