ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) Proteins (ASF1A)

ASF1A encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. Additionally we are shipping ASF1A Antibodies (135) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASF1A 25842 Q9Y294
ASF1A 66403 Q9CQE6
ASF1A 294408  
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Top ASF1A Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Human His tag,T7 tag   50 μg Log in to see 4 Days
$522.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Log in to see 4 to 8 Days
$504.90
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$492.31
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$2,489.67
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,498.83
Details
Escherichia coli (E. coli) Human T7 tag,His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details
Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$318.85
Details

ASF1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) (ASF1A) Interaction Partners

Human ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) (ASF1A) interaction partners

  1. faithful transmission of histone variants involves ASF1 and can be impacted by replication stress, with ensuing consequences for cell fate and tumorigenesis

  2. uncovered DNA-PKcs-dependent DNA damage-induced ASF1A phosphorylation, which enhances chromatin assembly, promoting MMS22L-TONSL recruitment and, hence, Rad51 loading.

  3. ASF1A is aberrantly over-expressed in GIC tumors and plays key roles in GIC development and progression by stimulating the transcription of beta-catenin target genes.

  4. ASF1a promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 by ATM at double-strand breaks.

  5. These data suggest that CAF-1- and ASF1A-H3-H4-dependent deposition of the histone (H3-H4)2 tetramers is compatible with MMR and protects the discontinuous daughter strand from unnecessary degradation by MMR machinery.

  6. Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.

  7. quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2

  8. Thermodynamic analysis of the quaternary complex together with structural modeling support that ASF1 and MCM2 could form a chaperoning module for histones H3 and H4 protecting them from promiscuous interactions.

  9. Data indicate Tousled-like kinases (TLK1) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b function.

  10. findings show that ASF1A, a histone-remodeling chaperone specifically enriched in the metaphase II oocyte, is necessary for reprogramming of adult dermal fibroblasts into undifferentiated induced pluripotent stem cell

  11. The ATR checkpoint pathway causes a histone chaperone normally associated with the replication fork, ASF1a, to degrade through a CRL1(betaTRCP)-dependent ubiquitination/proteasome pathway, leading to the localized dechromatinization and gene repression.

  12. Co-depletion of the histone chaperones ASF1a and ASF1b in human cells induces all hallmarks of alternative lengthening of telomeres in both primary and cancer cells.

  13. Asf1a plays a role in regulating IE genes by assembling chromatin onto histone-free viral DNA by 3 h postinfection with herpes simplex virus 1

  14. The authors propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly.

  15. NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex

  16. Low ASF1A is associated with familial longevity.

  17. HIRA plays a unique, ASF1a-independent role, which is required for the localization of HP1

  18. Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells.

  19. Identify marks on histones H3-H4 bound to Asf1 and changes induced upon replication stress.

  20. ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.

Mouse (Murine) ASF1 Anti-Silencing Function 1 Homolog A (S. Cerevisiae) (ASF1A) interaction partners

  1. Asf1a-mediated nucleosome disassembly provides a means for resolution of bivalent domain barriers for induction of lineage-specific genes during differentiation.

  2. tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9.

ASF1A Protein Profile

Protein Summary

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.

Gene names and symbols associated with ASF1A

  • anti-silencing function 1A histone chaperone (ASF1A)
  • anti-silencing function 1A histone chaperone (Asf1a)
  • anti-silencing function 1A histone chaperone L homeolog (asf1a.L)
  • 2310079C17Rik protein
  • asf1 protein
  • asf1-a protein
  • asf1a protein
  • asf1a-a protein
  • asf1aa protein
  • asf1ab protein
  • C79052 protein
  • CGI-98 protein
  • CIA protein
  • HSPC146 protein
  • XAsf1 protein

Protein level used designations for ASF1A

ASF1 anti-silencing function 1 homolog A , CCG1-interacting factor A , anti-silencing function protein 1 homolog A , hAsf1 , hAsf1a , hCIA , histone chaperone ASF1A , anti-silencing function 1 , anti-silencing function protein 1 homolog , histone chaperone ASF1 , ASF1 anti-silencing function 1-like protein A , histone chaperone ASF1A-like , Anti-silencing function protein 1 homolog , Anti-silencing function protein 1 homolog A-A , anti-silencing function protein 1 homolog A-A , anti-silencing function protein 1-A , chromatin assembly factor , histone chaperone asf1-A , histone chaperone asf1a-A

GENE ID SPECIES
25842 Homo sapiens
66403 Mus musculus
294408 Rattus norvegicus
618099 Bos taurus
723780 Gallus gallus
100307033 Ovis aries
100328718 Oryctolagus cuniculus
476273 Canis lupus familiaris
714761 Macaca mulatta
100229097 Taeniopygia guttata
106025604 Cavia porcellus
446260 Xenopus laevis
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