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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Additionally we are shipping ATG4B Proteins (13) and many more products for this protein.
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Human Polyclonal ATG4B Primary Antibody for IF, IHC (p) - ABIN1882065
Pontén, Westermark: Properties of human malignant glioma cells in vitro. in Medical biology 1978
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Human Polyclonal ATG4B Primary Antibody for IHC (p), WB - ABIN388494
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG4B Primary Antibody for WB - ABIN1881082
Kabeya, Mizushima, Yamamoto, Oshitani-Okamoto, Ohsumi, Yoshimori: LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. in Journal of cell science 2004
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Human Polyclonal ATG4B Primary Antibody for ELISA, IHC - ABIN2908806
Andaloussi, Habib, Soylemes, Laknaur, Elhusseini, Al-Hendy, Ismail: Defective expression of ATG4D abrogates autophagy and promotes growth in human uterine fibroids. in Cell death discovery 2018
These results support the conclusion that CML24 affects autophagy progression through interactions with ATG4.
AtATG4a is catalytically more active and has broad AtATG8 substrate specificity compared with AtATG4b. [ATG4b]
ATG4B expression was observed markedly upregulated by EWS (show EWSR1 Antibodies)-FLI1 (show FLI1 Antibodies) overexpression, and silencing of ATG4B dramatically inhibits autophagy in Ewing sarcoma cells.
study demonstrates that Rab7b (show RAB7B Antibodies) regulates LC3 (show MAP1LC3A Antibodies) processing by modulating Atg4B activity; taken together, findings reveal Rab7b (show RAB7B Antibodies) as a novel negative regulator of autophagy through its interaction with Atg4B
ATG4B contains a C-terminal LIR (show CD300C Antibodies) motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 (show GABARAPL2 Antibodies)
O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition
these results demonstrate a novel association of ATG4B positive expression with HER2 (show ERBB2 Antibodies) positive breast cancers
Knockdown of ATG4B had only a minor effect on AMPK (show PRKAA1 Antibodies) activation and G1 phase arrest in liver kinase B1 (show STK11 Antibodies)-deficient or AMPK (show PRKAA1 Antibodies)-inhibited cancer cells.
Our work describes an MST4 (show MST4 Antibodies)-ATG4B signaling axis that influences glioblastoma autophagy and malignancy
Data show that ULK1 (show ULK1 Antibodies), a protein kinase (show CDK7 Antibodies) activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316.
Reporter assay showed that HSF1 (show HSF1 Antibodies) increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 (show HSF1 Antibodies) bound to the site (-1429 to -1417) in ATG4B gene promoter region.
The structure and regulatory machinery of Atg4b [review]
At the microtubule-actin crossover junction, ATG4B detaches LC3B (show MAP1LC3B Antibodies) from melanosomal membranes by enzymatic delipidation.
ATG4B contains a C-terminal LIR (show CD300C Antibodies) motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 (show MAP1LC3B Antibodies)
miR (show MLXIP Antibodies)-34a might regulate the autophagic activity and can cause injury in ischemia reperfusion injured renal tubular epithelial cells (RTEC) via targeting Atg4B. Atg4B knockdown inhibited autophagy in RTECs.
the ATG4B protease and autophagy play a crucial role protecting epithelial cells against bleomycin-induced stress and apoptosis
REDD1 (show DDIT4 Antibodies)/TXNIP (show TXNIP Antibodies) complex expression is sufficient to induce reactive oxygen species, suppress ATG4B activity and activate autophagy.
these findings demonstrate a role for Ser (show SIGLEC1 Antibodies)-383 and Ser (show SIGLEC1 Antibodies)-392 phosphorylation of ATG4B in control of autophagy.
mTOR (show FRAP1 Antibodies) inhibition alleviates Huntington's disease progression by inducing Atg4b-dependent autophagic flux.
An autophagy-related gene, Atg4b, is identified as a de novo target gene of C/EBP BETA (show CEBPB Antibodies) and is shown to play an important role in 3T3-L1 adipocyte differentiation.
the RNF5-mediated control of membranalATG4B reveals a novel layer in the regulation of LC3 (show MAP1LC3A Antibodies) processing and autophagy.
The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ATG4 autophagy related 4 homolog B
, cysteine protease ATG4B
, autophagy 4b variant 1Cysteine protease ATG4B
, autophagy 4b variant 3
, cysteine protease ATG4b
, APG4 autophagy 4 homolog B
, autophagy-related protein 4 homolog B
, autophagy-related cysteine endopeptidase 2B
, AUT-like 1 cysteine endopeptidase
, autophagy-related cysteine endopeptidase 1
, APG4 (ATG4) autophagy-related homolog B
, AUT-like 1, cysteine endopeptidase
, autophagin 1
, autophagy-related 4B
, cysteine protease involved in autophagy APG4-B
, autophagy related 4 homolog B
, autophagy related 4-like protein B