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Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.
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Human Polyclonal ATG4C Primary Antibody for IHC (p), WB - ABIN1882160
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG4C Primary Antibody for IHC (p), WB - ABIN1882159
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
Show all 6 Pubmed References
We demonstrate that, in breast cancer cells, ATM (show ATM Antibodies) and ATG4C are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype.
miR (show MLXIP Antibodies)-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1 (show BECN1 Antibodies).
we demonstrated for the first time that triggering of TRPV1 (show TRPV1 Antibodies) induces autophagy in mouse thymocytes resulting in AMPK (show PRKAA1 Antibodies) activation and increased Atg4C mRNA expression
Atg4C is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized.
ATG4 autophagy related 4 homolog C
, APG4 (ATG4) autophagy-related homolog C
, cysteine protease ATG4C
, APG4 autophagy 4 homolog C
, AUT-like 1, cysteine endopeptidase
, AUT-like 3 cysteine endopeptidase
, autophagy-related cysteine endopeptidase 3
, autophagy-related protein 4 homolog C
, autophagin 3
, autophagy-related 4C
, cysteine protease involved in autophagy
, autophagy related 4-like protein C