ATM Interactor Proteins (ATMIN)

Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Additionally we are shipping ATM Interactor Antibodies (43) and ATM Interactor Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATMIN 234776 Q6P9S1
Rat ATMIN ATMIN 315037  
ATMIN 23300 O43313
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Top ATM Interactor Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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ATMIN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

More Proteins for ATM Interactor (ATMIN) Interaction Partners

Mouse (Murine) ATM Interactor (ATMIN) interaction partners

  1. ASCIZ/ATMIN is dispensable for ATM activation, and contradict the previously reported dependence of ATM on ASCIZ/ATMIN.

  2. oncogenic MYC expression, which is synthetic lethal with Dynll1 deletion in B-2 cells, did not further reduce B-1a cell numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1 axis was also required for the early-juvenile development of aggressive MYC-driven and p53-deficient B cell lymphomas.

  3. ATMIN, therefore, has multiple roles in different cell types, and its absence results in perturbed hematopoiesis, especially during stress conditions and aging.

  4. ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma.

  5. These results reveal a new requirement for ATMIN-dependent ATM signaling in TP53-deficient glioblastoma multiforme, indicating a pro-tumorigenic role for ATM in the context of these tumors.

  6. findings reveal a novel model for an intestinal bowel disease phenotype that occurs upon combined loss of the DNA repair cofactors ATMIN and NBS1

  7. Results show that Atmin is critical for normal kidney development through Wnt signaling pathway modifications.

  8. ATMIN has a role in lung morphogenesis and ciliogenesis through transcriptional regulation

  9. UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage

  10. the antagonism and redundancy of ATMIN and NBS1 constitute a crucial regulatory mechanism for ATM signaling and function.

  11. ASCIZ (ATMIN) regulates B cell development by inducing DYNLL1 (LC8) expression which in turn prevents Bim-dependent apoptosis in immature B cells in the bone marrow

  12. The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.

  13. ATMIN has dual functions as an efficiency factor for DNA base damage repair as well as a key transcriptional regulator of early lung development.

  14. Identify a role for ATMIN in regulating the maintenance of genomic stability and tumor suppression in B cells.

  15. Asciz is essential for mouse embryonic development and lung organogenesis likely as a transcription factor

  16. ATMIN mediates ATM activation by oxidative stress, and thereby ATMIN protects the aging brain by preventing accumulation of DNA damage.

Human ATM Interactor (ATMIN) interaction partners

  1. The study results improve our understanding of the ATMIN-KRas axis leading to HNSCC migration or invasion and metastasis and facilitates the identification of possible therapy targets of downstream genes for designing effective therapeutic strategies in personalized medicine

  2. ASCIZ/ATMIN is dispensable for ATM activation, and contradict the previously reported dependence of ATM on ASCIZ/ATMIN.

  3. WRNIP1 connects PCNA monoubiquitination with ATMIN/ATM to activate ATM signalling in response to replication stress and contribute to the maintenance of genomic stability.

  4. Studies suggest that ATM INteractor (ATMIN) could be an important biomarker in disease prognosis and treatment that might lighten the burden of chronic kidney disease and also affect on its progression.

  5. Repression of ATMIN in hypoxia is mediated by both p53 and HIF-1alpha in an oxygen dependent manner.

  6. ATMIN is required for cell cycle progression and chromosome segregation following replication stress.ATMIN is required for the ATM-mediated signaling and recruitment of 53BP1 to DNA damage sites upon replication stress.

  7. The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.

  8. these results imply a potential cellular interference between DYNLL1 and ATMIN functions.

  9. Asciz (Atmin) deletion or knock-down does not affect ATM levels and activation in mouse, chicken, or human cells

  10. ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein (ASCIZ) required for repair of abasic sites after methylating and oxidative DNA damage but not double-strand breaks. Forms DNA damage-induced foci with RAD51 and ssDNA. ASCIZ foci depend on MLH1.

  11. ATMIN defines a novel NBS1-independent pathway of ATM signalling.

  12. These data suggest that ASCIZ may affect the choice between competing base repair pathways in a manner that reduces the amount of substrates available for Ig gene conversion.

  13. ASCIZ (ATMIN) is structurally related to the yeast ATM/ATR substrate Mdt1 (Pin4/Ybl051c); both proteins contain SQ/TQ cluster domains and interact with N-terminal FHA domains of CHK2/Rad53 kinases.

ATM Interactor (ATMIN) Protein Profile

Protein Summary

Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM.

Gene names and symbols associated with ATM Interactor Proteins (ATMIN)

  • ATM interactor (Atmin)
  • ATM interactor (ATMIN)
  • ATM interactor L homeolog (atmin.L)
  • ATM interactor (atmin)
  • ASCIZ protein
  • mKIAA0431 protein
  • RGD1305781 protein
  • ZNF822 protein

Protein level used designations for ATM Interactor Proteins (ATMIN)

ATM/ATR-substrate CHEK2-interacting zinc finger protein , ATM/ATR-substrate CHK2-interacting zinc finger protein , ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein , ATM interactor , ATM INteracting protein , ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein , zinc finger protein 822

GENE ID SPECIES
234776 Mus musculus
315037 Rattus norvegicus
426138 Gallus gallus
443691 Xenopus laevis
571606 Danio rerio
717395 Macaca mulatta
738730 Pan troglodytes
781217 Bos taurus
100031731 Monodelphis domestica
100069801 Equus caballus
100356797 Oryctolagus cuniculus
100449573 Pongo abelii
100483255 Ailuropoda melanoleuca
100487308 Xenopus (Silurana) tropicalis
100548302 Meleagris gallopavo
100565641 Anolis carolinensis
100585291 Nomascus leucogenys
23300 Homo sapiens
100724714 Cavia porcellus
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