anti-ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 (ABCA12) Antibodies

The membrane-associated protein encoded by ABCA12 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCA12 26154 Q86UK0
ABCA12 74591  
ABCA12 301482  
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Top anti-ABCA12 Antibodies at antibodies-online.com

Showing 10 out of 50 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ABCA12 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Stomach 100 μL 2 to 3 Days
$319.00
Details
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$581.17
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of ABCA12 using LOVO whole cell lysates 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-ABCA12 Polyclonal Antibody, Unconjugated (ABIN1386605) at 1:200 followed by conjugation to the secondary antibody and DAB staining Paraformaldehyde-fixed, paraffin embedded rat testis, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with ABCA12 Polyclonal Antibody, Unconjugated  at 1:600 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining 100 μL 3 to 7 Days
$329.45
Details
Human Goat Un-conjugated ELISA   100 μg 11 to 14 Days
$507.83
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL 14 to 21 Days
$428.45
Details
Human Rabbit Un-conjugated WB ABCA12 antibody used at 1 ug/ml to detect target protein. 50 μg 9 to 11 Days
$449.29
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL 14 to 21 Days
$428.45
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL 14 to 21 Days
$428.45
Details

Top referenced anti-ABCA12 Antibodies

  1. Human Polyclonal ABCA12 Primary Antibody for ICC, IF - ABIN408721 : Sakai, Akiyama, Sugiyama-Nakagiri, McMillan, Sawamura, Shimizu: Localization of ABCA12 from Golgi apparatus to lamellar granules in human upper epidermal keratinocytes. in Experimental dermatology 2007 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal ABCA12 Primary Antibody for WB - ABIN2781522 : Hlavá?, Brynychová, Václavíková, Ehrlichová, Vrána, Pecha, Koževnikovová, Trnková, Gat?k, Kopperová, Gut, Sou?ek: The expression profile of ATP-binding cassette transporter genes in breast carcinoma. in Pharmacogenomics 2013 (PubMed)

More Antibodies against ABCA12 Interaction Partners

Zebrafish ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 (ABCA12) interaction partners

  1. The morphological findings are akin to epidermal changes in harlequin ichthyosis and CEDNIK syndrome, autosomal recessive keratinization disorders due to mutations in the ABCA12 and SNAP29 genes, respectively.

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 (ABCA12) interaction partners

  1. A novel pathogenic variant Val1927Leu was identified in a patient with severe harlequin ichthyosis.

  2. Letter: describe ABCA12 mutations in patients with autosomal recessive congenital ichthyosis and report evidence of a founder effect of this mutation in the Spanish population.

  3. A novel heterozygous missense mutation was identified in ATP-binding cassette sub-family A member 12 (ABCA12) within a family afflicted with keratosis pilaris. In addition, upregulated ABCA12 expression levels in the sebaceous glands of patients with nevus comedonicus were investigated.

  4. the present study has identified a novel homozygous deleterious intronic variant, which is associated with a severe phenotype of HI.

  5. two missense ABCA12 mutations were uncovered in both of the affected brothers.

  6. we identified three novel mutations and one reported mutation in the TGM1 and ABCA12 genes, respectively, in affected siblings of five Saudi unrelated families

  7. Genes ABCC7, A3, A8, A12, and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels.

  8. Autosomal recessive inheritance of mutations in the ATP-binding cassette, subfamily A, member 12 (ABCA12, OMIM*607800, chromosome 2q35) gene was found to be responsible for the disease.

  9. Identification of the key promoter element of ABCA12 in this study may provide relevant information for genetic diagnosis of recessive congenital ichthyosis.

  10. Ssnger sequencing of the parents of neonates deceased patients with Harlequin ichthyosis identified novel mutations in ABCA12 gene.

  11. ABCA12 mutations result in defective lipid transport via lamellar granules in the keratinocytes, leading to ichthyosis phenotypes from malformation of the stratum corneum lipid barrier.

  12. Report a consanguineous family of Arab Muslim origin with several members displaying a severe form of congenital ichthyosiform erythroderma. Identified a region of homozygosity shared by all patients on 2q34, in a region harbouring the ABCA12 gene.

  13. We show that homozygosity for a novel c.4676G>T transition in the ABCA12 gene, resulting in a p.G1559V substitution, causes non-bullous congenital ichthyosiform erythroderms in 5 members of an extended family.

  14. The authors report on a 2282del4 mutation that may be associated with ichthyosis vulgaris in a Pakistani population.

  15. The researchers report on another fatal case of Harlequin ichthyosis that may be associated with mutations of the ABCA12 gene

  16. AKT signaling helps ABCA12 deficient keratinocytes survive during the keratinization process.

  17. Mutation analysis revealed that 52% of the survivors of harlequin ichthyosis had compound heterozygous mutations of ABCA12, whereas all deaths were associated with homozygous mutations of ABCA12.

  18. loss of ABCA12 function leads to a defective lipid barrier in the stratum corneum, resulting in an ichthyotic phenotype (Review)

  19. Our results clearly demonstrate that ABCA12 deficiency impairs glucosylceramide accumulation in lamellar bodies, thereby strongly indicating that ABCA12 transports glucosylceramide to the inner leaflet of lamellar bodies.

  20. Cloning, characterization and chromosome mapping of ABCA12.

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 12 (ABCA12) interaction partners

  1. these findings suggest an essential role for ABCA12 in transferring not only lipids, which are required for the formation of multilamellar structures in the stratum corneum, but also proteolytic enzymes that are required for normal desquamation.

  2. Data indicate that ABC transporter A family member 12 knockout (Abca12(-/-)) epidermis had 5-fold more beta-glucocerebrosidase (GCase) protein, and a 5-fold increase in GCase activity.

  3. ABCA12 mutations result in defective lipid transport via lamellar granules in the keratinocytes, leading to ichthyosis phenotypes from malformation of the stratum corneum lipid barrier.

  4. ABCA12 regulates the cellular cholesterol metabolism via an LXRbeta-dependent posttranscriptional mechanism.

  5. Results indicate that disrupted keratinocyte differentiation during the fetal development is involved in the pathomechanism of HI and, during maturation, Abca12(-/-) epidermal keratinocytes regain normal differentiation processes.

  6. ABCA12 plays pivotal roles in lung and skin barrier functions in Harlequin ichthyosis disease midel.

  7. Abca12 is a regulator of lipid transport and homeostasis.

  8. ABCA12 activity is required for the generation of long-chain ceramide esters that are essential for the development of normal skin structure and function

ABCA12 Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with ABCA12

  • ATP binding cassette subfamily A member 12 (ABCA12) antibody
  • ATP-binding cassette, sub-family A (ABC1), member 12 (abca12) antibody
  • ATP-binding cassette, sub-family A (ABC1), member 12 (Abca12) antibody
  • ATP binding cassette subfamily A member 12 (Abca12) antibody
  • 4832428G11Rik antibody
  • 4833417A11Rik antibody
  • ARCI4A antibody
  • ARCI4B antibody
  • cb352 antibody
  • ICR2B antibody
  • LI2 antibody
  • sb:cb352 antibody

Protein level used designations for ABCA12

ATP-binding cassette, sub-family A (ABC1), member 12 , ATP-binding cassette, sub-family A, member 12 , ATP-binding cassette sub-family A member 12 , ATP-binding cassette sub-family A member 12-like , ATP-binding cassette transporter 12

GENE ID SPECIES
424011 Gallus gallus
459924 Pan troglodytes
523479 Bos taurus
558335 Danio rerio
694427 Macaca mulatta
100341171 Oryctolagus cuniculus
100464882 Ailuropoda melanoleuca
26154 Homo sapiens
478900 Canis lupus familiaris
100512445 Sus scrofa
74591 Mus musculus
301482 Rattus norvegicus
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