anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) Antibodies

The membrane-associated protein encoded by ABCB11 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCB11 Kits (14) and ABCB11 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCB11 8647 O95342
ABCB11 27413 Q9QY30
ABCB11 83569 O70127
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Top anti-ABCB11 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Anti- ABCB11 Picoband antibody, IHC(P) IHC(P): Human Liver Cancer Tissue Anti- ABCB11 Picoband antibody, Western blotting All lanes: Anti ABCB11 at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 50ug Lane 2: Mouse Liver Tissue Lysate at 50ug Lane 3: SMMC Whole Cell Lysate at 40ug Predicted bind size: 146KD Observed bind size: 146KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-ABCB11 C-term Pab (ABIN390059) is used in Western blot to detect ABCB11 in mouse liver tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, IHC (p) Western Blot: ABCB11 Antibody [NBP1-89319] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human Tonsil tissue Immunohistochemistry: ABCB11 Antibody [NBP1-89319] - Staining of human liver shows moderate membranous positivity in hepatocytes. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Mouse Un-conjugated ICC, IHC, IHC (p), WB Human Liver (formalin-fixed, paraffin-embedded) stained with ABCB11 antibody ABIN305775 at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Anti-ABCB11 / BSEP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg Log in to see 11 to 14 Days
$727.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269604 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of mouse liver tissue sample,using Phospho-ABCB11 (Ser690) Antibody(ABIN6269604). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of ABCB11 using K562 whole cell lysates ABIN6279192 at 1/100 staining Human lymph node tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts of mouse liver tissue sample,using ABCB11 Antibody(ABIN6270451). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image BSEP antibody [N3C1], Internal detects ABCB11 protein at membrane by immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: ABCB11 protein stained by BSEP antibody [N3C1], Internal , diluted at 1:500. Blue: Hoechst 33343 staining. WB Image Sample (30 ug of whole cell lysate) A: JurKat 5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunocytochemistry/Immunofluorescence: ABCB11 Antibody [NBP1-31824] - Sample: A431 cells were fixed in iced-cold MeOH for 5 min. Green: ABCB11 protein stained by BSEP antibody, Internal diluted at 1:500. Blue: Hoechst 33343 staining. Western Blot: ABCB11 Antibody [NBP1-31824] - Sample (30 ug of whole cell lysate) A: JurKat 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 8 to 11 Days
$514.63
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cells, using ABCB11 antibody. 100 μL Log in to see 16 Days
$334.77
Details

Top referenced anti-ABCB11 Antibodies

  1. Human Polyclonal ABCB11 Primary Antibody for IHC (p), WB - ABIN390059 : Strautnieks, Bull, Knisely, Kocoshis, Dahl, Arnell, Sokal, Dahan, Childs, Ling, Tanner, Kagalwalla, Németh, Pawlowska, Baker, Mieli-Vergani, Freimer, Gardiner, Thompson: A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. in Nature genetics 1998 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ABCB11 Primary Antibody for IHC, IHC (p) - ABIN4277166 : Sambrotta, Strautnieks, Papouli, Rushton, Clark, Parry, Logan, Newbury, Kamath, Ling, Grammatikopoulos, Wagner, Magee, Sokol, Mieli-Vergani, Smith, Johnson, McClean, Simpson, Knisely, Bull, Thompson: Mutations in TJP2 cause progressive cholestatic liver disease. in Nature genetics 2014 (PubMed)
    Show all 2 Pubmed References

More Antibodies against ABCB11 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Data show the gene expression profiling of ABC (show ABCB6 Antibodies) transporters in seven tissues.

  2. cloned one partial and two full gene sequences, which show high degree of identity with mammalian Pgp1 (ABCB1 (show ABCB1 Antibodies)), BSEP (ABCB11) and MRP2 (ABCC2 (show ABCC2 Antibodies)) efflux transporters and found identical relative expression patterns for both liver and primary hepatocytes

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. We concluded that Egyptian patients having chronic hepatitis C genotype 4 with CC genotype of ABCB11 SNP 1331T>C and high plasma bile acid levels at cutoff value of 75.5 mumol/L were associated with advanced hepatic fibrosis.

  2. The overrepresentation of mutated variants of the 1331T > C ABCB11 polymorphism in the ICP group suggests its contribution to the etiology of the intrahepatic cholestasis of pregnancy. Analysis of genotypes' co-existence pointed to the possibility of the mutated variants of polymorphism 1954A > G ABCB4 (show ABCB4 Antibodies) and 1331T > C ABCB11 having a summation effect on the development ofintrahepatic cholestasis of pregnancy

  3. These data demonstrated that c.386G>A (p.C129Y) in ABCB11 was a causative mutation that correlated with the phenotype of patients with PFIC2, the impairment of biliary excretion into bile canaliculi, and the absence of canalicular BSEP expression in liver histological assessments.

  4. FIC1 (show ATP8B1 Antibodies), BSEP, and MDR3 (show ABCB4 Antibodies) represent hepatobiliary transport proteins essential for bile formation.

  5. This is the first report on a diagnostic test for simultaneous genotyping of IFNL3 (show IL28B Antibodies), ABCB11, and RNF7 (show RNF7 Antibodies) in Chronic hepatitis C (CHC (show CLTC Antibodies)) patients. Reliable and inexpensive, the assay should provide useful information for the clinical management of CHC (show CLTC Antibodies), like identification of patients at risk of rapid disease progression or with high chances of response to classic therapy.

  6. Residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of partial external biliary diversion in progressive familial intrahepatic cholestasis type 2.

  7. Study suggested that the CC genotype of rs2287616 variant of ABCB11 gene might contribute to anti-tuberculosis drug-induced cholestatic liver injury in Chinese patients.

  8. Case Report: compound heterozygotes for two missense mutations of the ABCB11 with a mild form of progressive familial intrahepatic cholestasis type 2.

  9. Patients with a confirmed ABCB11 or tight junction protein 2 (show TJP2 Antibodies) gene mutation (n = 7) had a minimally detectable THBA proportion (0.23-2.99% of total BAs). Three patients with an ATP8B1 (show ATP8B1 Antibodies) mutation had an elevated THBA proportion (7.51-37.26%).

  10. By these complementary approaches, a set of ten novel BSEP interaction partners was identified. With the exception of radixin (show RDX Antibodies), all other interaction partners were integral or membrane-associated proteins including proteins of the early secretory pathway and the bile acyl-CoA synthetase (show SLC27A5 Antibodies), the second to last, ER-associated enzyme of bile salt synthesis

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11) interaction partners

  1. Studied effect of endotoxin exposure on liver following partial hepatectomy; found endotoxin exposure induced autoantibody production against Bsep (bile salt export pump) leading to dysfunction of hepatobiliary transporter systems.

  2. Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp (show SLC10A1 Antibodies) and Bsep in liver.

  3. mechanism of increased biliary lipid secretion in Bsep-/- mice is based on increased expression of the responsible canalicular transporter proteins.

  4. LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) and PKA control ABCB11 trafficking and polarization in hepatocytes.

  5. CA feeding of Bsep (-/-) mice increased hepatic Cyp3a11 protein levels.

  6. FXR (show NR1H4 Antibodies) regulates BSEP in an isoform-dependent and species-specific manner

  7. Ursodeoxycholic acid fed to abcb11-/- mice caused liver damage and the appearance of biliary tetra- and penta-hydroxy bile acids.

  8. Hepatic Abcb11 overexpression in mice increases the conservation of bile acids within the enterohepatic circulation.

  9. The authors show that two of these transporters, ABCB11 and ATP8B1 (show ATP8B1 Antibodies), are functional targets of miR (show MLXIP Antibodies)-33, a micro-RNA that is expressed from within an intron of SREBP-2 (show SREBF2 Antibodies).

  10. Abcb11 deficiency induces cholestasis coupled to impaired beta-fatty acid oxidation in mice.

ABCB11 Antigen Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

Gene names and symbols associated with ABCB11

  • ATP binding cassette subfamily B member 11 (ABCB11) antibody
  • bile salt export pump (LOC100489744) antibody
  • bile salt export pump (LOC100565276) antibody
  • bile salt export pump (EDI_111220) antibody
  • bile salt export pump (EDI_272930) antibody
  • bile salt export pump (abcb11) antibody
  • ATP binding cassette subfamily B member 11 (Abcb11) antibody
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11 (Abcb11) antibody
  • ABC16 antibody
  • ABCB11 antibody
  • BRIC2 antibody
  • BSEP antibody
  • BSEP/SPGP antibody
  • Lith1 antibody
  • PFIC-2 antibody
  • PFIC2 antibody
  • PGY4 antibody
  • Spgp antibody

Protein level used designations for ABCB11

ATP-binding cassette, sub-family B (MDR/TAP), member 11 , bile salt export pump , bile salt export pump-like , ABC member 16, MDR/TAP subfamily , ATP-binding cassette sub-family B member 11 , progressive familial intrahepatic cholestasis 2 , sister p-glycoprotein , ATP-binding cassette, sub-family B, member 11 , sister of P-glycoprotein , liver bile salt export pump

GENE ID SPECIES
424170 Gallus gallus
470717 Pan troglodytes
488390 Canis lupus familiaris
531150 Bos taurus
100024107 Monodelphis domestica
100052359 Equus caballus
100083318 Ornithorhynchus anatinus
100404882 Callithrix jacchus
100454135 Pongo abelii
100473353 Ailuropoda melanoleuca
100489744 Xenopus (Silurana) tropicalis
100518154 Sus scrofa
100543935 Meleagris gallopavo
100565276 Anolis carolinensis
100590891 Nomascus leucogenys
5879080 Entamoeba dispar SAW760
5914265 Entamoeba dispar SAW760
100136688 Oncorhynchus mykiss
100337637 Cavia porcellus
8647 Homo sapiens
27413 Mus musculus
100008767 Oryctolagus cuniculus
83569 Rattus norvegicus
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