ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins (ABCB1B)

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
Rat ABCB1B ABCB1B 24646  
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,744.22
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$9,912.25
Details
Yeast REACT_Entamoeba histolytica His tag   50 μg Log in to see 8 to 11 Days
$341.00
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Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details

ABCB1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Results show that CD133 and MDR1 expression increase in recurrent pediatric pilocytic astrocytomas (PAs (show PASK Proteins)) following chemotherapy, and in drug resistant tumor cells. CD133 regulates MDR1 expression via the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) signaling. These results provide evidence that CD133 contributes to multidrug resistance by regulating MDR1 levels via the PI3K (show PIK3CA Proteins)-Akt (show AKT1 Proteins)-NF-kappaB (show NFKB1 Proteins) signal pathway.

  2. PG accumulation assay is a new, unique tool for the parallel determination of the function of the ABCG2, ABCB1 (show ABCB1 Proteins), and ABCC1 (show ABCC1 Proteins) multidrug transporters

  3. Abcb1a (show ABCB1 Proteins)/b(-/-);Abcg2(-/-) mice revealed increased brain penetration of rapamycin (13-fold), AZD8055 (7.7-fold), and NVP-BEZ235 (4.5-fold), but not ZSTK474 relative to WT mice. Importantly, ABC (show ABCB6 Proteins) transporters limited rapamycin brain penetration to subtherapeutic levels, while the reduction in NVP-BEZ235 brain penetration did not prevent target inhibition.

  4. ABCB1 (show ABCB1 Proteins) genotype is not a significant determinant of interindividual variability in dabigatran and rivaroxaban pharmacokinetics

  5. High MDR1 expression is associated with multidrug resistance in breast cancer.

  6. inhibition of autophagy led to the decrease in stemness, restoration of mitochondrial proteins and reduced expression of CD44 (show CD44 Proteins), ABCB1 (show ABCB1 Proteins) and ADAM17 (show ADAM17 Proteins)

  7. The T-allele of ABCB1 (show ABCB1 Proteins)-C3435T gene polymorphism has demonstrated to be a good prognosis factor for resistance, progression free survival and overall survival in HER2 (show ERBB2 Proteins)-positive Breast Cancer patients.

  8. we review the emerging role of molecular dynamics simulation techniques in our understanding of the membrane-embedded conformation of P-gp (show ABCB4 Proteins)--{REVIEW}

  9. Studied ABCB1 (show ABCB1 Proteins) protein expression immunohistochemically in twelve human post-mortem brain regions known to play a role in schizophrenia, in 13 patients with schizophrenia and nine controls; found a significantly reduced density of ABCB1 (show ABCB1 Proteins)-expressing neurons in the left habenula.

  10. Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (show ABCC6 Proteins), ABCB1 (show ABCB1 Proteins) and CYP2C8 (show CYP2C8 Proteins) associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 Proteins), multi-drug resistance protein, MDR1 (show ABCB4 Proteins)).Drugs with ER < 1 (show MIER1 Proteins) almost do not bind the main binding cavity (MBC (show CACNA1C Proteins)) of P-gp (show ABCB4 Proteins).

  2. conclusion, MDR1 (show ABCB4 Proteins) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A Proteins)-II layer.

  3. Mdr1 (show ABCB4 Proteins) enforces T Cell homeostasis in the presence of intestinal bile acids.

  4. Loss of ABCB1 (show ABCB1 Proteins) expression is associated with neonatal hyperbilirubinemia.

  5. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  6. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  7. Chrysosplenetin inhibited P-gp (show ABCB4 Proteins) activity and reverse the up-regulated P-gp (show ABCB4 Proteins) and MDR1 (show ABCB4 Proteins) levels induced by artemisinin.

  8. Tamsulosin and tolterodine with P-gp (show ABCB4 Proteins) gene expression and activity in an enantiomer-specific way.

  9. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  10. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP binding cassette subfamily B member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • ABC20 protein
  • Abcb1 protein
  • CD243 protein
  • CLCS protein
  • GP170 protein
  • mdr protein
  • Mdr1 protein
  • Mdr1b protein
  • P-GP protein
  • Pgy-1 protein
  • Pgy1 protein

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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