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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antibodies (31) and many more products for this protein.
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Promoter methylation was found to be an important mechanism in gene regulation of ABCB1 (show ABCB1 Proteins) in parental cancer cell lines and their drug-resistant sublines.
This study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3 (show NANOS3 Proteins), ABCB1 (show ABCB1 Proteins) and IL23R (show IL23R Proteins)) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk.
Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase (show TXK Proteins) inhibitors act as p-glycoprotein antagonists.
Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin by inhibiting energy metabolism which may suppress P-gp (show ABCB4 Proteins) function.
Results imply that LHBs, in association with HIF-1alpha (show HIF1A Proteins), induces MDR1 overexpression, which may contribute to the pathogenic changes in chronic hepatitis B infection.
endothelin-A receptor (show EDNRA Proteins)-activated ABCB1 (show ABCB1 Proteins) expression has a role in nintedanib resistance in FGFR1 (show FGFR1 Proteins)-driven small cell lung cancer
Review/Meta-analysis: CRISPR-Cas9 system is a useful tool for the modification of ABCB1 (show ABCB1 Proteins) gene and reversing multi-drug resistance in osteosarcoma cells.
ABCB1 (show ABCB1 Proteins) expression represents the primary (sometimes exclusive) resistance mechanism in neuroblastoma (show ARHGEF16 Proteins) cells with acquired resistance to SNS (show SCN10A Proteins)-032.
Histone deacetylase (show HDAC1 Proteins) inhibitors induce P-gp (show ABCB4 Proteins) expression in colorectal cancer in two distinct ways: transcriptional activation and mRNA stabilization
Ectopic expression of ABCB1 (show ABCB1 Proteins) promoted the miR (show MLXIP Proteins)-595-overexpressing HO8910PM and SKOV-3 cell proliferation, colony formation and invasion.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (show ABCB4 Proteins), multi-drug resistance protein, MDR1 (show ABCB4 Proteins)).Drugs with ER < 1 (show MIER1 Proteins) almost do not bind the main binding cavity (MBC (show CACNA1C Proteins)) of P-gp (show ABCB4 Proteins).
conclusion, MDR1 (show ABCB4 Proteins) and BCRP are expressed on apical membranes of the rodent placental SynT (show STX1A Proteins)-II layer.
Mdr1 (show ABCB4 Proteins) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (show ABCB1 Proteins) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (show ABCB4 Proteins) activity and reverse the up-regulated P-gp (show ABCB4 Proteins) and MDR1 (show ABCB4 Proteins) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (show ABCB4 Proteins) gene expression and activity in an enantiomer-specific way.
Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1