anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) Antibodies

The protein encoded by ABCC3 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCC3 Kits (24) and ABCC3 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABCC3 8714 O15438
ABCC3 76408 B2RX12
ABCC3 140668 O88563
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Top anti-ABCC3 Antibodies at

Showing 10 out of 99 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-ABCC3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate Host:  Rabbit  Target Name:  CHAD  Sample Type:  Human Adult Placenta  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IP, WB Western blot analysis of MRP3 expression in HepG2 (A), MCF7 (B), MDAMB435 (C) whole cell lysates. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB ABCC3 Antibody (Center) flow cytometric analysis of MDA-MB435 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. ABCC3 antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCC3 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL 6 to 8 Days
Human Goat Un-conjugated ELISA   100 μg 6 to 7 Days
Human Rabbit Un-conjugated ELISA, WB Western Blot (WB) analysis of specific cells using MRP3 Polyclonal Antibody. 100 μL Available
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Mouse Un-conjugated IHC (fro), IF, WB   1 mL 6 to 8 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6274945 staining HeLa by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod ABIN6274945 at 1/100 staining Human brain cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Porcine Liver Tissue. Figure. Western Blot; Sample: Recombinant ABCC3, Human. 100 μg 13 to 16 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western Blot at 1:1000 dilution Lane 1: HepG2 whole cell lysate Lane 2: human liver lysate Lysates/proteins at 20 ug per lane. ABCC3 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 to 3 Days

Top referenced anti-ABCC3 Antibodies

  1. Dog (Canine) Polyclonal ABCC3 Primary Antibody for WB - ABIN2781505 : Müller, Asher, Heled, Cohen, Risch, Rund: Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. in Leukemia research 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ABCC3 Primary Antibody for FACS, ICC - ABIN445912 : Mossoba, Vohra, Toomer, Pugh-Bishop, Keltner, Topping, Black, Olejnik, Depina, Belgrave, Sprando, Flynn, Wiesenfeld, Sprando: Diglycolic acid induces HepG2/C3A liver cell toxicity in vitro. in Toxicology in vitro : an international journal published in association with BIBRA 2018 (PubMed)

More Antibodies against ABCC3 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) interaction partners

  1. CGI may function as an enhancer of the transcription of ABCC3.

  2. Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3).

  3. Data show that bladder cancer is associated with perturbed expression of MRP3 and BCRP.

  4. Histological subtype of epithelial ovarian cancer correlated with the expression of PgP, MRP1, and MRP3. The lowest level of Pgp and MRP1 expression was found in endometrioid ovarian cancers

  5. miR-148a-siRNA and rifampin inhibited estradiol upregulation of MRP3 expression. miR-148a may be involved in the estrogen induction in intrahepatic cholestasis of pregnancy via PXR signaling. MRP3 may be involved.

  6. ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.

  7. PXR is a potential biomarker for predicting outcome and activates MRP3 transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC.

  8. This study highlights the importance of ABCC3 transporters in drug resistance to chemotherapy in the context of breast cancer.

  9. Wnt signaling regulates ABCC3 expression in colon cancer cells, with the ABCC3 locus being a target of the transcription factors TCF7L2 and beta-catenin.

  10. ABCC3 is an important oncoprotein involved in glycolysis and drug resistance

  11. This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma

  12. High MRP expression is associated with sorafenib resistance in hepatocellular carcinoma.

  13. ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response.

  14. Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism.

  15. ABCC3 expression may serve as a marker for MDR and predictor for poor clinical outcome of NSCLC.

  16. A functional Nrf2 response element within the eighth intron of the ABCC3 gene.

  17. Renal function of MRP3 is related to renal cell proliferation and cyst formation and that restoring MRP3 may be an effective therapeutic approach for polycystic kidney disease.

  18. These results suggest that carboplatin and paclitaxel may induce drug resistance mediated by MDR1 and MRP3, which may be enhanced by the simultaneous use of both drugs.

  19. ABCC3 promoter methylation does not seem to exhibit any impact on maximum platelet aggregation and clopidogrel response at all

  20. Epidermal growth factor - mediated epithelial-mesenchymal transition induces ABCC3 mRNA in MDA-MB-468 breast cancer cells. The process is calcium dependant.

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 (ABCC3) interaction partners

  1. Abbcc3 knock-out mice have enhanced platelet response to clopidogrel due to increased formation of clopidogral active metabolite.

  2. data show that this transporter activity is involved in ABCC3-induced senescence, demonstrating that this protein has a complex role in cancer, since its loss of function may promote escape from OIS and tumor formation

  3. Transport of cefadroxil by ABCC3 and ABCC4 was saturable with K(m) values of 2.5 +/- 0.7 and 0.25 +/- 0.07 mM, respectively.

  4. role of the bile acid membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut, in the hepatic growth response elicited by bile acids and in liver regeneration after partial hepatectomy

  5. Both Abcc2 and Abcc3 significantly influenced the PK properties of MTX.

  6. InsP(3)R2-mediated Ca(2+) signals enhance organic anion secretion into bile by targeting Mrp2 to the canalicular membrane.

  7. Data show that Abcc2, Abcc3, and Abcg2 together mediate the rapid elimination of MTX and 7OH-MTX.

  8. These results suggest that Mrp3 plays major roles in the efflux transport of various glucuronide conjugates from the enterocytes to the portal blood in the small intestine together with unknown transporter(s)

  9. induction of Mrp3 plays a significant role in hepatocyte protection during obstructive cholestasis

  10. VDR has a role in the protection of colon cells from bile acid toxicity through regulation of the Mrp3 expression

  11. Mrp3 does not have a major role in bile salt physiology, but is involved in the transport of glucuronidated compounds, which could include glucuronidated bile salts in humans

  12. Basolateral excretion of acetaminophen-glucuronide is nearly completely dependent on the function of Mrp3. Altered disposition in Mrp3-/- mice is associated with reduced hepatotoxicity.

  13. Radixin knockout increases Mrp3 expression.

  14. Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 are reviewed.

  15. Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo.

  16. Abcc6/3(-/-) double knock-out mice exhibited connective tissue mineralization similar to that in Abcc6 (-/-) mice.

  17. The lithogenic diet induced biliary hyperplasia and reduced bile salt transporter ABCC3 expression in C57L mice.

  18. Abcc3 transports MTX and 7OH-MTX back from the liver into the circulation, leading to increased plasma levels and urinary excretion.

  19. Complex pharmacokinetic behavior of ezetimibe depends on intestinal abcc2, abcc3, and abcg2.

  20. Report Role of hepatic Mrp3 transporter in prevention of bile acid toxicity after partial hepatectomy in mice.

ABCC3 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined\; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Gene names and symbols associated with ABCC3

  • ATP binding cassette subfamily C member 3 (ABCC3) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (Abcc3) antibody
  • ATP binding cassette subfamily C member 3 (Abcc3) antibody
  • 1700019L09Rik antibody
  • ABC31 antibody
  • cMOAT2 antibody
  • EST90757 antibody
  • Mlp2 antibody
  • MOAT-D antibody
  • Mrp3 antibody

Protein level used designations for ABCC3

ATP-binding cassette sub-family C member 3 , canalicular multispecific organic anion transporter 2 , canicular multispecific organic anion transporter , multi-specific organic anion transporter D , multidrug resistance associated protein , multidrug resistance-associated protein 3 , ATP-binding cassette protein C3 , ATP-binding cassette transporter , transporter , ATP-binding cassette, sub-family C (CFTR/MRP), member 3 , MLP-2 , MRP-like protein 2 , multidrug resistance protein 3 , organic anion transporter

8714 Homo sapiens
76408 Mus musculus
140668 Rattus norvegicus
100713825 Cavia porcellus
422099 Gallus gallus
533151 Bos taurus
491084 Canis lupus familiaris
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