ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 (ABCC9) ELISA Kits

The protein encoded by ABCC9 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 Antibodies (126) and ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ABCC9 10060 O60706
Anti-Mouse ABCC9 ABCC9 20928 P70170
Anti-Rat ABCC9 ABCC9 25560 Q63563
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Top ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 ELISA Kits at

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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.132 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests Log in to see 13 to 16 Days

More ELISA Kits for ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 Interaction Partners

Human ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 (ABCC9) interaction partners

  1. Significant gene-based association between the ABCC9 gene and hippocampal sclerosis-aging appeared to be driven by a region in which a significant haplotype-based association.

  2. ABCC9 gene has been associated with Dilated Cardiomyopathy. 3 pathogenic variants have been associated with DCM: 1 missense -CM1410876-, 1 nonsense -CM040975-, and 1 small indel -CX041212.

  3. Analysis of three Cantu syndrome-associated gain of function mutations indicates that all lead to overactive K(ATP) channels, but at least two mechanisms underlie the observed gain of function: decreased ATP inhibition and enhanced MgADP activation.

  4. The patient reported here gives further evidence that these syndromes are an expression of the ABCC9-related disorders, ranging from hypertrichosis and acromegaloid facies to the severe end of Cantu syndrome.

  5. ABCC9 polymorphism associated with Brain disorders: sleep problems. depression and HS-Aging.

  6. single amino acid difference can account for the markedly different diazoxide sensitivities between channels containing either the SUR1 or SUR2A subunit isoforms.

  7. We describe novel ABCC9 variants in human brain, corresponding to altered 3'UTR length, which could lead to targeting by miR-30c

  8. Results show that a polymorphism in ABCC9 is associated with aging pathology, and exposure to sulfonylurea drugs is associated with increased risk for aging pathology among individuals who died age 85 and older

  9. This study confirmed that specific ABCC9 single-nucleotide polymorphisms is associated with HS-Aging pathology in the Alzheimer disease.

  10. ABCC9 is a susceptibility gene for early repolarization syndrome and Brugada syndrome.

  11. A mutation (V734I) in ABCC9 increases susceptibility to coronary spasm and acute myocardial infarction.

  12. two different de novo missense mutations in the two patients with coarse facial features and hypertrichosis

  13. This study showed that variants in the SUR2 gene (ABCC9) associate with epidemiological variation in human sleep duration, which is also influenced by inter-individual differences in seasonal adaptation and chronotype.

  14. Electrophysiological experiments show that mutations in ABCC9, associated with Cantu syndrome, reduce the ATP-mediated potassium channel inhibition, resulting in channel opening.

  15. Cantu syndrome is caused by mutations in ABCC9

  16. mammalian oocytes express K(ATP) channels. Real-time PCR revealed that mRNA for Kir6.1, Kir6.2, SUR2A and SUR2B, were present in human oocytes of different stages.

  17. sequence variants in ABCC9 is unlikely to contribute to variation in postural change in systolic blood pressure

  18. These findings suggest that abnormal localization of the SUR2A K(+) channel protein leads to reduced K(ATP) channel activity in familial hypokalemic periodic paralysis.

  19. Assembly limits the pharmacological complexity of ATP-sensitive potassium channels

  20. down-regulation of this channel may facilitate myometrial function during late pregnancy

Pig (Porcine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 (ABCC9) interaction partners

  1. Results describe a new function of the Kir6.1-SUR2A complex, namely the regulation of paracellular permeability through tight junctions.

  2. Kir6.1/SUR2B is the major functional K(ATP) channel complex in the pig MMA and MCA, and mRNA expression studies suggest that the human MMA shares this K(ATP) channel subunit profile

Mouse (Murine) ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 (ABCC9) interaction partners

  1. Cardiac SUR2A levels were significantly increased while Kir6.2 levels were not affected. Hypoxia did not induce phosphorylation of extracellular signal-regulated kinases (ERK1/2) or protein kinase B (Akt), but triggered phosphorylation of AMP activated protein kinase (AMPK). AICAR, an activator of AMPK, increased the level of SUR2A in H9c2 cells. We conclude that oxygen increases SUR2A level by activating AMPK.

  2. K(ATP) channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2

  3. Data show that PI3K/Akt signalling pathway and lactate dehydrogenase (LDH) play a crucial role in increase of cardiac ATP-binding cassette transporter sub-family C member 9 (SUR2A) induced by in vivo exposure to 18% oxygen.

  4. Sulfhydration of SUR2B subunit modifies tyrosine nitration of Kir6.1 subunit within the KATP channel complex.

  5. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant

  6. In the absence of Abcc9, the newborn heart fails to transition normally from fetal to mature myocardial metabolism.

  7. Native K(ATP) channels in mouse vas deferens myocytes are a heterocomplex of K(IR)6.1 channels and SUR2B subunits.

  8. The results confirm that Kir6.2 contributes to APD shortening in both atria and ventricle during metabolic stress, and that SUR1 is required for atrial APD shortening while SUR2A is required for ventricular APD shortening.

  9. the role of CpG methylation in regulating SUR1 and SUR2 expression

  10. Report unique properties of the ATP-sensitive potassium channel in the mouse ventricular cardiac conduction system.

  11. Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A.

  12. Results suggest that oral nicotinamide is a regulator of SUR2A expression and has a potential as a drug that can improve physical endurance in conditions where this effect would be desirable.

  13. Cardioprotection observed in the SUR2m mice is associated with a protected mitochondrial phenotype resulting from enhanced K(+) conductance that partially dissipated mitochondrial membrane potential.

  14. Our present study reinforces a role for the full-length SUR2 protein in cardioprotection.

  15. Transgenic mice with a sole increase in SUR2A expression had also increased cardiac resistance to ischaemia-reperfusion.

  16. results imply that specific activation domains stimulate transcription by binding to distinct Mediator subunits; activation by E1A and Elk-1 requires recruitment of Mediator to a promoter by binding to its Sur2 subunit [sur2]

  17. The intermittent coronary artery vasospasm seen in Sur2(-/-) mice provides a model for the human disorder Prinzmetal variant angina and demonstrates that the SUR2 K(ATP) channel is a critical regulator of episodic vasomotor activity.

  18. Kir 6.1 gene expression was upregulated by almost 22-fold, whereas SUR2B was downregulated by threefold after inflammation. Decreased motility of colon during inflammation may be associated with changes in transcriptional regulation of Kir 6.1 and SUR2B.

  19. The dimerization induces the opening of the KATP channel, probably by causing a conformational change of SUR2x.

  20. results support the hypothesis that the mouse adenovirus type 1 (MAV-1) E1A-mSur2 interaction is important in MAV-1 replication in mice

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 9 (ABCC9) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extra-pancreatic ATP-sensitive potassium channels. Mutations in this gene are associated with cardiomyopathy dilated type 1O. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with ABCC9

  • ATP binding cassette subfamily C member 9 (ABCC9) antibody
  • ATP-binding cassette sub-family C member 8 (LOC581821) antibody
  • ABC transporter C family protein (abcC9) antibody
  • ATP-binding cassette sub-family C member 9 (LOC100470981) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (abcc9) antibody
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 9 (Abcc9) antibody
  • ATP binding cassette subfamily C member 9 (Abcc9) antibody
  • ABC37 antibody
  • ABCC9 antibody
  • AI414027 antibody
  • AI449286 antibody
  • ATFB12 antibody
  • CANTU antibody
  • CMD1O antibody
  • DDBDRAFT_0215814 antibody
  • DDBDRAFT_0216237 antibody
  • DDB_0215814 antibody
  • DDB_0216237 antibody
  • si:dkey-183c2.3 antibody
  • Sur2 antibody
  • SUR2A antibody
  • SUR2B antibody

Protein level used designations for ABCC9

ATP-binding cassette, sub-family C, member 9 , ATP-binding cassette, sub-family C (CFTR/MRP), member 9 , ATP-binding cassette sub-family C member 9 , ATP-binding cassette sub-family C member 9-like , sulfonylurea receptor subunit 2 , ATP-binding cassette transporter sub-family C member 9 , sulfonylurea receptor 2 , sulfonylurea-binding protein 2 , Sulfonylurea receptor 2 , cardiac ventricle sulfonyl urea receptor , sulphonylurea receptor 2B

465338 Pan troglodytes
581821 Strongylocentrotus purpuratus
654489 Macaca mulatta
8624976 Dictyostelium discoideum AX4
100010456 Monodelphis domestica
100064351 Equus caballus
100470981 Ailuropoda melanoleuca
561160 Danio rerio
418200 Gallus gallus
10060 Homo sapiens
486638 Canis lupus familiaris
100127449 Sus scrofa
100336551 Bos taurus
20928 Mus musculus
25560 Rattus norvegicus
100008700 Oryctolagus cuniculus
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