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A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. Additionally we are shipping ATAD2 Proteins (3) and and many more products for this protein.
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Human Polyclonal ATAD2 Primary Antibody for ICC, IF - ABIN4281939
Raeder, Birkeland, Trovik, Krakstad, Shehata, Schumacher, Zack, Krohn, Werner, Moody, Wik, Stefansson, Holst, Oyan, Tamayo, Mesirov, Kalland, Akslen, Simon, Beroukhim, Salvesen: Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. in PLoS ONE 2013
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Results show that ATAD2 expression is regulated by PCAT-14 which activates Hedgehog (show SHH Antibodies) pathway in hepatocellular carcinoma cells, depending on miR (show MLXIP Antibodies)-372.
BRDs are overexpressed in castration-resistant prostate cancer and that ATAD2 and BRD2 (show BRD2 Antibodies) have prognostic value.
a novel function of ATAD2 in cancer and for the first time identify a reader of newly synthesized histone di-acetylation-marks during replication.
this work defines Atad2 as a facilitator of general chromatin-templated activities such as transcription.
ANCCA act as a potential biomarker for therapeutic strategy and prognostic prediction for squamous cell lung carcinoma.
ATAD2 protein overexpression was a poor independent prognostic factor for gastric cancer patients
ATAD2 protein expression may be a potential predictor of recurrence-free survival in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) patients after curative resection and ATAD2 may have prognostic value in patients with early stage HCC (show FAM126A Antibodies) or normal serum alpha-fetoprotein (show AFP Antibodies) level.
Suppression of ATAD2 impaired the growth of HepG2 and Hep3B subcutaneous xenografts, by enhancing apoptosis and p-p53 (show TP53 Antibodies) and p-p38 (show CRK Antibodies) levels.
Data indicate that gene expression alterations in endometrial carcinoma samples with high ATPase (show DNAH8 Antibodies) family, AAA (show APP Antibodies) domain containing 2 protein (ATAD2) expression showed upregulation of several cancer-related genes including B-MYB (show MYBL2 Antibodies) gene.
Results showed that ATPase family AAA domain-containing 2 overexpression was associated with progression and prognosis of colorectal cancer.
Results found that ATAD2 is highly expressed in hepatocellular carcinoma tissues and could affect the expression of hedghog pathway.
EZH2 (show EZH2 Antibodies) and ANCCA are androgen regulated and strongly expressed in early prostate morphogenesis and during puberty, suggesting their important role in prostate development.
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.
ATPase family AAA domain-containing protein 2
, AAA nuclear coregulator cancer-associated protein