anti-Abhydrolase Domain Containing 12 (ABHD12) Antibodies

ABHD12 encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. Additionally we are shipping ABHD12 Proteins (8) and ABHD12 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ABHD12 76192 Q99LR1
ABHD12 499913 Q6AYT7
ABHD12 26090 Q8N2K0
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Top anti-ABHD12 Antibodies at antibodies-online.com

Showing 10 out of 66 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ABHD12 Antibody Titration: 0.2-1 ug/ml Positive Control: Human Spleen 100 μL 2 to 3 Days
$289.00
Details
Mouse Goat Un-conjugated ELISA, WB EB08783 (0.3µg/ ml) staining of Mouse Brain lysate (35µg/ protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Abhd12 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Thymus 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using ABHD12 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Available
$363.46
Details
Human Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from COLO cells, using ABHD12 antibody. ABIN6274788 staining COLO205 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11 to 12 Days
$390.77
Details
Mouse Goat Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
$462.00
Details

Top referenced anti-ABHD12 Antibodies

  1. Mouse (Murine) Polyclonal ABHD12 Primary Antibody for ELISA, WB - ABIN451662 : Blankman, Simon, Cravatt: A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. in Chemistry & biology 2007 (PubMed)

More Antibodies against ABHD12 Interaction Partners

Mouse (Murine) Abhydrolase Domain Containing 12 (ABHD12) interaction partners

  1. The substrate profiling study for ABHD12 suggested that this enzyme requires glycosylation for optimal activity and that it has a strong preference for very-long-chain lipid substrates.

  2. In mouse macrophages, disruption of ABHD12 and ABHD16A respectively increases and decreases both lysophosphatidylserines and lipopolysaccharide-induced cytokine production.

  3. FAAH but not monoacyl glycerol lipase exerts important protective actions against 2-arachidonoyl glycerol-induced cellular damage.

  4. provide a molecular model for PHARC, where disruption of ABHD12 causes deregulated LPS metabolism and the accumulation of proinflammatory lipids that promote microglial and neurobehavioral abnormalities

  5. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract disease.

  6. Data reveal that 85% of brain 2-arachidonoylglycerol hydrolase activity can be ascribed to monoacylglycerol lipase(MAGL), and the remaining 15% is catalyzed by ABHD6 and ABHD12.

Human Abhydrolase Domain Containing 12 (ABHD12) interaction partners

  1. Findings in Usher Syndrome predicted the potential function of this gene in the development of hearing and vision loss, particularly with regard to impaired signal transmission, and identified a novel nonsense variant to expand the variant spectrum in ABHD12.

  2. ABHD12 is enriched on the endoplasmic reticulum membrane, where most of the very-long-chain fatty acids are biosynthesized in cells.

  3. This study presented the various mutation of ABHD12 responsible for PHARC syndrome.

  4. Study identified a new missense mutation, p.T253R, in ABHD12, which is functionally linked to the neurodegenerative disease PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and early-onset cataract), as demonstrated by its deactivation of monoacylglycerol lipase activity and inability to rescue zebrafish abhd12 knockdown phenotypes.

  5. ABHD12 mutation in 2 PHARC (Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract)patients who suffered from deaf-blindness and dysfunctional central and peripheral nervous systems.

  6. Null mutations in the ABHD12 gene lead to PHARC syndrome, a neurodegenerative disease including polyneuropathy, hearing loss, cerebellar ataxia, RP, and early-onset cataract. Our study allowed us to report 5 new mutations in ABHD12.

  7. This is the first report of compound heterozygosity in PHARC and the first study to describe how a mutation might affect ABHD12 expression and function.

  8. ABHD12 mutations are not a frequent cause of ataxia at least in Southern Italy

  9. After the identification of the ABHD12 mutation in this family, one patient underwent neurological examination which revealed ataxia, but no polyneuropathy

  10. Data show that the three hydrolases are genuine MAG lipases; medium-chain saturated MAGs were the best substrates for hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and 2-isomers of arachidonoylglycerol.

  11. Mutations in the ABHD12 gene cause polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract disease.

ABHD12 Antigen Profile

Protein Summary

This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene names and symbols associated with ABHD12

  • abhydrolase domain containing 12 (ABHD12) antibody
  • abhydrolase domain containing 12 (CC1G_02966) antibody
  • abhydrolase domain containing 12 (PTRG_02160) antibody
  • abhydrolase domain containing 12 S homeolog (abhd12.S) antibody
  • abhydrolase domain containing 12 (Abhd12) antibody
  • 1500011G07Rik antibody
  • 6330583M11Rik antibody
  • ABHD12 antibody
  • ABHD12A antibody
  • AI431047 antibody
  • AW547313 antibody
  • BEM46L2 antibody
  • C20orf22 antibody
  • dJ965G21.2 antibody
  • PHARC antibody

Protein level used designations for ABHD12

abhydrolase domain containing 12 , monoacylglycerol lipase ABHD12-like , 2-arachidonoylglycerol hydrolase , abhydrolase domain-containing protein 12 , monoacylglycerol lipase ABHD12

GENE ID SPECIES
477004 Canis lupus familiaris
744997 Pan troglodytes
6012413 Coprinopsis cinerea okayama7130
6339600 Pyrenophora tritici-repentis Pt-1C-BFP
100380988 Xenopus laevis
100449601 Pongo abelii
100466451 Ailuropoda melanoleuca
100342158 Oryctolagus cuniculus
76192 Mus musculus
499913 Rattus norvegicus
26090 Homo sapiens
768242 Bos taurus
421249 Gallus gallus
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