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ABHD2 encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes.
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Suppression of ABHD2 in OVCA420 cells increased phosphorylated p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies), platinum resistance, and side population cells (p<0.01, respectively). Conversely, overexpression of ABHD2 decreased resistance to anoikis (p<0.05) and the amount of phosphorylated p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies) in OVCA420 and SKOV3 cells.
A mutant ABHD2 developed with alanine in place of Ser (show SIGLEC1 Antibodies)(207).
ABHD2 gene single nucleotide polymorphisms, such as rs12442260 contribute to chronic obstructive pulmonary disease susceptibility in the Chinese Han population.
ABHD2 is highly expressed in spermatozoa, binds progesterone, and acts as a progesterone-dependent lipid hydrolase by depleting the endocannabinoid 2-arachidonoylglycerol (2AG) from plasma membrane.
Our results showed that the ABHD2 was expressed in atherosclerotic lesions, and that the ABHD2 expression was significantly higher in the patients with UA than with SA.
LABH-2 protein is a member of a novel family of membrane bound enzymes whose function has yet to be determined; highest expression level in the testis
These findings suggest that derangement in alveolar phospholipid metabolism can induce emphysema, and that Abhd2 plays a critical role in maintaining lung structural integrity.
This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. Alternative splicing of this gene results in two transcript variants encoding the same protein.
abhydrolase domain containing 2
, abhydrolase domain-containing protein 2
, alpha/beta hydrolase domain containing protein 2
, lung alpha/beta hydrolase 2
, protein PHPS1-2
, alpha/beta hydrolase fold protein
, abhydrolase domain-containing protein 2-A