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ABLIM1 encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. Additionally we are shipping Actin Binding LIM Protein 1 Antibodies (55) and Actin Binding LIM Protein 1 Proteins (4) and many more products for this protein.
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Exon 11 inclusion isoform of ABLIM1 may have a muscle-specific function, and its abnormal splicing could be related to muscle symptoms of myotonic dystrophy type 1.
SNP rs727532 in ABLIM1 (10q25) had significant association in the multivariate test & strong associations with novelty seeking, harm avoidance, reward dependence and alcohol dependence in the COGA sample.
abLIM1 regulated the localization of tubulin, migration, and fusion in osteoclasts. Thus, these results indicate that abLIM1 negatively controls osteoclast differentiation by regulating cell migration and fusion mediated via actin formation.
ABLIM1 is associated with the regulation of preosteoclast motility via the PI3K/Akt/Rac1 pathway during RANKL-mediated osteoclastogenesis.
these results make Ablim1 a candidate for controlling aspects of left-right identity and patterning.
AbLIM-L mutant mice exhibit no apparent morphological or functional defects in photoreceptors and inner retinal neurons. Retinofugal projections and synaptic maturation also appear normal; abLIM-M is likely the isoform related to axon guidance.
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.
actin-binding LIM protein 1
, actin binding LIM protein 1
, actin-binding LIM protein 1-like
, actin-binding LIM protein family member 1
, actin-binding double-zinc-finger protein
, actin-binding double zinc finger protein