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The protein encoded by AFAP1 is a Src binding partner.
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AFAP-1 is a key mediator in the inflammatory signaling-induced, translocation-independent attenuation of P-glycoprotein efflux in brain capillary endothelial cells.
The genotype frequencies of six SNPs in AFAP1, GMDS and PTGFR genes were conformed to Hardy-Weinberg equilibrium (HWE).
Data indicate three loci associated with primary open-angle glaucoma (POAG) were located upstream of ATP binding cassette transporter 1 (ABCA1 (show ABCA1 ELISA Kits)), within actin filament associated protein 1 (AFAP1) and within GDP-mannose 46-dehydratase (GMDS (show GMDS ELISA Kits)).
Methylation of the long noncoding RNA AFAP1-AS1 (show PTGDR ELISA Kits) is reduced in BE and EAC (show CYLD ELISA Kits), and its expression inhibits cancer-related biologic functions of EAC (show CYLD ELISA Kits) cells.
AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB 231 breast cancer cells.
These data define, for the first time, the requirement of AFAP1 for the spatial and temporal regulation of cSrc activity in the normal breast, specifically for milk production.
In E16 (show SLC7A5 ELISA Kits) mouse embryos, AFAP expression levels concentrated in the olfactory bulb, cortex, forebrain, cerebellum, and various peripheral sensory structures.In P3 mouse pups, overall expression was reduced. (AFAP-110)
Data suggest that one major function of AFAP-110 is to relay signals from protein kinase C alpha that direct the activation of c-Src and the formation of podosomes.
Actin filament associated protein-110 (AFAP) colocalizes with cSrc to promote cSrc activation and cell migration.
AFAP120 may coordinate Src signaling with the dynamic changes in the actin cytoskeleton that drive growth cone motility and axon elongation.
These results indicate that AFAP120 plays a role in organizing dynamic actin structures during neuronal differentiation and suggest that AFAP120 may help regulate the transition from motile precursor to morphologically differentiated neurons.
The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene.
actin filament associated protein 1
, actin filament-associated protein 1-like
, 110 kDa actin filament-associated protein
, actin filament-associated protein 1
, actin filament-associated protein, 110 kDa
, neural actin filament protein