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Acad8 encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Additionally we are shipping Acad8 Proteins (8) and and many more products for this protein.
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we discovered a novel c.1156_1158delCAG mutation in ACAD8 in patients with isobutyryl-CoA dehydrogenase deficiency , and investigated the mutation spectrum of ACAD8.
first enzymatic and molecular confirmation of a deficiency of this enzyme in a patient
the bovine ACAD8 full-length mRNA and genomic DNA sequence were obtained and its gene structure was determined through alignment of the genomic DNA sequence to the mRNA sequence
N-ethyl-N-nitrosourea-mediated mutagenesis caused alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice.
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.
acyl-Coenzyme A dehydrogenase family, member 8 , isobutyryl-CoA dehydrogenase, mitochondrial , acyl-coenzyme A dehydrogenase family, member 8 , acyl-Coenzyme A dehydrogenase family member 8 , acyl-CoA dehydrogenase family, member 8 , isobutyryl-CoA dehydrogenase, mitochondrial-like , activator-recruited cofactor 42 kDa component , ACAD-8 , acyl-CoA dehydrogenase family member 8