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The protein encoded by ACSL4 is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Additionally we are shipping ACSL4 Antibodies (103) and and many more products for this protein.
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Human ACSL4 Protein expressed in Wheat germ - ABIN1305715
Zhang, Li, Zhang, Xiao: A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation. in The Journal of biological chemistry 2011
ACSL3 (show Acsl3 Proteins) distribution closely overlapped with proteins involved in trafficking from the trans-Golgi network and endosomes. In contrast, the ACSL4 localisation pattern more closely followed that of calnexin (show CANX Proteins) which is an endoplasmic reticulum resident chaperone.
The regulatory network among peroxisomal ABCD2:ACSL4:VLCFA serves as a novel regulator of cartilage homeostasis, and these data may provide novel insights into the role of peroxisomal fatty acid metabolism in pathogenesis of human osteoarthritis (OA).
Study demonstrated that ACSL4 was overexpressed in HCC (show FAM126A Proteins).
These results suggest that ACSL1 (show Acsl1 Proteins), ACSL4 and ACSL5 (show ACSL5 Proteins) expression is regulated by ER signaling pathways and ACSL5 (show ACSL5 Proteins) is a potential novel biomarker for predicting prognosis of breast cancer patients.
studies have identified a novel substrate-induced posttranslational regulatory mechanism by which AA downregulates ACSL4 protein expression in hepatic cells.
Data show that ELOVL7, SOCS3 (show SOCS3 Proteins), ACSL4 and CLU (show CLU Proteins) were upregulated while PRKAR1A (show PRKAR1A Proteins) and ABCG1 (show ABCG1 Proteins) were downregulated in the phlegm-dampness group.
ACSL4 is not only a sensitive monitor of ferroptosis, but also an important contributor of ferroptosis.
ACLS4 and ACLS3 have roles in insulin (show INS Proteins) secretion
Silencing of ACSL4 eliminated the 17beta-estradiol-induced increase in AA and EPA uptake.
ACSL4 plays a tumor-suppressive role in gastric cancer.
Report PPARdelta (show PPARD Proteins)-mediated regulatory mechanism for ACSL4 expression in liver tissue and cultured hepatic cells.
Sequence analysis of a 1.5-kb fragment of the Acsl4 promoter revealed the absence of a TATA box and the presence of many putative binding sites for transcription factors including Sp1 (show SP1 Proteins) and CREB (show CREB1 Proteins).
Acsl4 is a phosphoprotein whose phosphorylation is hormone-dependent.
These results indicate that the ACS4 protein specifically expressed in brain plays an important role in arachidonate metabolism and neuronal differentiation in the brain.
the involvement of SHP2 (show PTPN11 Proteins) activity in the regulation of the expression of the fatty acid-metabolizing enzyme ACSL4
Results indicate that fatty acid binding protein H-FABP (show FABP3 Proteins) and CoA ligase 4 ACSL4 genes might serve as markers to improve fat (IMF (show MDFI Proteins)) content in the breeding system.
ACSL4 Single Nucleotide Polymorphism G2645A is associated with several meat quality traits.
Polymorphisms within the ACSL4 gene are associated with growth and meat quality.
The analyses of mutant lines revealed strongly overlapping functions of LACS4 and LACS9 in lipid trafficking from the endoplasmic reticulum to the plastid.
The combined inactivation of LACS1 (show Acsl1 Proteins) and LACS4 in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.
acyl-CoA synthetase long-chain family member 4
, long-chain-fatty-acid--CoA ligase 4
, Long-chain-fatty-acid--CoA ligase 4
, long-chain-fatty-acid--CoA ligase 4-like
, LACS 4
, acyl-CoA synthetase 4
, fatty-acid-Coenzyme A ligase, long-chain 4
, lignoceroyl-CoA synthase
, long-chain acyl-CoA synthetase 4
, long-chain fatty-acid-Coenzyme A ligase 4
, fatty acid-Coenzyme A ligase, long chain 4
, fatty acid Coenzyme A ligase, long chain 4
, fatty acid-Coenzyme A ligase long chain 4
, acyl-CoA synthetase long-chain family member 3