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This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. Additionally we are shipping AOAH Antibodies (27) and AOAH Kits (8) and many more products for this protein.
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Alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and that Aoah+/+ mice recover more rapidly than do Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumonia.
AOAH has a role in modulating microbiota signals that drive Th17 polarization and influence mucosal T-cell immunity
role in clearing and catabolizing both free LPS (show TLR4 Proteins) and the LPS (show TLR4 Proteins) in circulating LPS (show TLR4 Proteins)-lipoprotein complexes
Recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in in mice that lack AOAH, a lipase (show LIPG Proteins) that partially deacylates the bacterial cell-wall lipopolysaccharide.
AOAH - Gene involved in innate immunity that have been associated with Chronic Rhinosinusitis.
AOAH rs60023210 variants may be associated with carotid intima-media thickness at bifurcation.
Polymorphisms in RYBP (show RYBP Proteins) and AOAH genes are associated with chronic rhinosinusitis in a Chinese population.
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.
acyloxyacyl hydrolase (neutrophil)
, acyloxyacyl hydrolase
, acyloxyacyl hydrolase-like