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This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. Additionally we are shipping AOAH Antibodies (49) and AOAH Kits (6) and many more products for this protein.
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By inactivating commensal LPS, AOAH thus prevents desensitization of lung epithelial cells. An enzyme that prevents severe lung inflammation/injury in Gram-negative bacterial pneumonia has the seemingly paradoxical effect of predisposing to a Th2-mediated airway disease.
AOAH modulates pelvic pain severity, suggesting that allelic variation in Aoah influences pelvic pain in interstitial cystitis.
Alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and that Aoah+/+ mice recover more rapidly than do Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumonia.
AOAH has a role in modulating microbiota signals that drive Th17 polarization and influence mucosal T-cell immunity
role in clearing and catabolizing both free LPS and the LPS in circulating LPS-lipoprotein complexes
produced by renal cortical tubule cells and secreted into urine, where it can deacylate lipopolysaccharides, a mechanism to limit inflammatory response to gram-negative bacteria in urinary tract
Recovery from the tolerant state induced by Gram-negative bacteria is greatly delayed in in mice that lack AOAH, a lipase that partially deacylates the bacterial cell-wall lipopolysaccharide.
analysis of AOAH function through its crystal structure and complex with lipopolysaccharide
AOAH - Gene involved in innate immunity that have been associated with Chronic Rhinosinusitis.
AOAH rs60023210 variants may be associated with carotid intima-media thickness at bifurcation.
Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population.
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.
acyloxyacyl hydrolase (neutrophil)
, acyloxyacyl hydrolase
, acyloxyacyl hydrolase-like