Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins (APPL1)

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

1. APPL1 positively mediated leptin (show LEP Proteins) signaling.

2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

3. Results indicate that persistent rab5 (show RAB5A Proteins) overactivation through beta-cleaved carboxy-terminal fragment of APP (show APP Proteins)-APPL1 interactions constitutes a novel APP (show APP Proteins)-dependent pathogenic pathway in Alzheimer's disease

4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

5. Low expression of APPL1 is associated with metastasis in prostate cancer.

6. APPL1 endosomes represent a distinct population of Rab5 (show RAB5A Proteins)-positive sorting endosomes.

7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD

8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

9. A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.

10. ATM (show ATM Proteins) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

1. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (show PRKCZ Proteins), as well as its functional interaction with both PP2A (show PPP2R2B Proteins) and myosin IIa.

2. APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.

3. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (show TLR4 Proteins)-induced signaling, transcription, and cytokine secretion.

4. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Proteins)-induced Akt (show AKT1 Proteins) activation, migration, and invasion.

5. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 Proteins) signaling.

6. A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.

7. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

8. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

9. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS Proteins) sensitivity.

10. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Proteins) resistance and improves adipoR1 (show ADIPOR1 Proteins)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue