Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins (APPL1)

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies (72) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
Rat APPL1 APPL1 290537  
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Top Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Proteins at antibodies-online.com

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$554.07
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APPL1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 positively mediated leptin (show LEP Proteins) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (show RAB5A Proteins) overactivation through beta-cleaved carboxy-terminal fragment of APP (show APP Proteins)-APPL1 interactions constitutes a novel APP (show APP Proteins)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (show RAB5A Proteins)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.

  10. ATM (show ATM Proteins) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (show PRKCZ Proteins), as well as its functional interaction with both PP2A (show PPP2R2B Proteins) and myosin IIa.

  2. APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.

  3. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (show TLR4 Proteins)-induced signaling, transcription, and cytokine secretion.

  4. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Proteins)-induced Akt (show AKT1 Proteins) activation, migration, and invasion.

  5. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 Proteins) signaling.

  6. A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.

  7. APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.

  8. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  9. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS Proteins) sensitivity.

  10. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Proteins) resistance and improves adipoR1 (show ADIPOR1 Proteins)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Protein Profile

Protein Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1)
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1)
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (Appl1)
  • 2900057D21Rik protein
  • 7330406P05Rik protein
  • AI585782 protein
  • APPL protein
  • AW209077 protein
  • BB022931 protein
  • C88264 protein
  • DIP13 protein
  • DIP13alpha protein
  • RGD1309388 protein

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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