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anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway.

26 results:

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-664) antibody Primary Antibody

APPL2 Reactivity: Human IF, WB Host: Mouse Polyclonal unconjugated
Pubmed 1
Catalog No. ABIN527414
$440.00
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 174-273) antibody Primary Antibody

APPL2 Reactivity: Human IF, ELISA, WB Host: Mouse Monoclonal 1C10 unconjugated
Catalog No. ABIN527415
$440.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 124-152), (N-Term) antibody Primary Antibody

APPL2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5535840
$570.63
Plus shipping costs $45.00
400 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) antibody Primary Antibody

APPL2 Reactivity: Human ELISA, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5623056
$538.75
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 9 to 11 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (C-Term) antibody Primary Antibody

APPL2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5516603
$229.00
Plus shipping costs $45.00
100 μL
local_shipping Shipping to: United States
Delivery in 2 to 3 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) antibody Primary Antibody

APPL2 Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5702507
$380.00
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 13 to 16 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (PH domain) antibody Primary Antibody

APPL2 Reactivity: Human IP, IHC, ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2203417
$518.57
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 174-274), (PH domain) antibody Primary Antibody

APPL2 Reactivity: Human ELISA, WB Host: Mouse Monoclonal 1C10 unconjugated
Catalog No. ABIN2203418
$625.43
Plus shipping costs $45.00
100 μg
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
Catalog No. ABIN2203419
$625.43
Plus shipping costs $45.00
50 μg
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 122-152), (N-Term) antibody Primary Antibody

APPL2 Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2203424
$658.43
Plus shipping costs $45.00
200 μL
local_shipping Shipping to: United States
Delivery in 11 to 16 Business Days
  • Type Primary
    • Primary
  • Target Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2)
    • Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2)
    • Histone 3 (H3)
    • Tumor Protein P53 (TP53)
    • Epidermal Growth Factor Receptor (EGFR)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • CD4 Molecule (CD4)
    • tau Protein
    • Tumor Necrosis Factor alpha (TNF)
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Interferon gamma (IFNG)
    • Estrogen Receptor 1 (ESR1)
    • Albumin (ALB)
    • Nuclear Factor-KB P65 (NFkBP65)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • Tuberous Sclerosis 2 (TSC2)
    • CD44
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD19 Molecule (CD19)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E)
    • Myc Proto-Oncogene protein (MYC)
    • Integrin alpha M (ITGAM)
    • CD8
    • Histone H4
    • Interleukin 6 (IL6)
    • Vimentin (VIM)
    • Jun Proto-Oncogene (JUN)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • Interleukin 2 Receptor, alpha (IL2RA)
    • CD5 Molecule (CD5)
    • Interleukin 2 (IL2)
    • CD3
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Synuclein, alpha (SNCA)
    • Glial Fibrillary Acidic Protein (GFAP)
    • Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1)
    • CD14
    • Androgen Receptor (AR)
    • Mucin 1, Cell Surface Associated (MUC1)
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • CD34
    • Cyclin-Dependent Kinase 1 (CDK1)
    • Activating Transcription Factor 2 (ATF2)
  • Application
    • Western Blotting (WB)
    • ELISA
    • Immunofluorescence (IF)
    • Immunohistochemistry (IHC)
    • Immunoprecipitation (IP)
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Images available
  • Host
    • Rabbit
    • Mouse
  • Clonality
    • Polyclonal
    • Monoclonal
  • Clone
    • 1C10
  • Binding Specificity
    • AA 124-152
    • N-Term
    • AA 122-152
    • PH domain
    • AA 1-664
    • AA 174-274
    • AA 174-273
    • AA 619-662
    • C-Term
  • Conjugate
    • Un-conjugated
    • APC
    • Alkaline Phosphatase (AP)
    • Biotin
    • FITC
    • HRP
    • PE
  • Isotype
    • IgG
    • IgG2b kappa
    • Ig Fraction
    • IgG2b
    • kappa
  • Format
    • Liquid

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antigen Profile

Protein Summary

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) antibody
  • APPL2 antibody
  • Dip3b antibody
  • DIP13B antibody
  • MGC84621 antibody
  • RGD1563028 antibody

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus

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