anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antibodies

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
APPL2 362860  
APPL2 55198 Q8NEU8
APPL2 216190 Q8K3G9
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Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies at antibodies-online.com

Showing 10 out of 31 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged APPL2 is 0.3 ng/ml as a capture antibody. Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 monoclonal antibody (M06), clone 1C10.Lane 1: APPL2 transfected lysate (Predicted MW: 74.5 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of APPL2 Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate. 400 μL 2 to 3 Days
$515.63
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of APPL2 expression in transfected 293T cell line by APPL2 MaxPab polyclonal antibody.Lane 1: APPL2 transfected lysate(73.04 KDa).Lane 2: Non-transfected lysate. APPL2 MaxPab polyclonal antibody. Western Blot analysis of APPL2 expression in rat brain. 50 μg 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB   100 μg 11 to 14 Days
$837.83
Details
Human Rabbit Un-conjugated ELISA, WB   200 μL 11 to 16 Days
$658.43
Details
Human Rabbit PE ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit FITC ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit HRP ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Alkaline Phosphatase (AP) ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details
Human Rabbit Biotin ELISA, WB   200 μL 11 to 14 Days
$1,101.83
Details

Top referenced anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies

  1. Human Polyclonal APPL2 Primary Antibody for WB - ABIN4305242 : Canciglieri, Kuga, Muñoz, Gaspar, da Rocha, Breda, Anaruma, Minuzzi, da Silva, Cintra, de Moura, Ropelle, Pauli: The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle. in Life sciences 2018 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal APPL2 Primary Antibody for IF, WB - ABIN527414 : Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway. in The Journal of endocrinology 2011 (PubMed)

More Antibodies against Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. A negative correlation of expression is evident between APPL2 and OCC-1 genes in breast cancer specimen. Unlike OCC-1A/B which encodes a small protein, OCC-1D noncoding RNA overexpression lead to APPL2 downregulation in MCF7 cells.

  2. Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 gene provides a putative colorectal neoplasm progression index.

  3. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  4. ATM is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  5. It concludes that APPL2(PH) binding to BAR domain and Reptin is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin.

  6. C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver.

  7. Data indicate that a high level of APPL2 protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  8. analysis of APPL1 and APPL2 proteins and their interaction with Rab

  9. found significant evidence of association with overweight/obesity for rs2272495 and rs1107756. rs2272495 C allele and rs1107756 T allele both conferred a higher risk of being overweight and obese.

  10. Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population.

  11. Data suggest that although annexin A2 is not an exclusive marker of APPL1/2 endosomes, it has an important function in membrane recruitment of APPL proteins, acting in parallel to Rab5.

  12. significant fluorescence resonance energy transfer between APPL minimal BAR domain FRET pairs

  13. identification of a pathway directly linking the small GTPase Rab5, a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 and APPL2, two Rab5 effectors

  14. The findings suggest a role for APPL1 and APPL2 protein as dynamic scaffolds that modulate RAB5-associated signaling endosomal membranes by their ability to undergo domain-mediated oligomerization, membrane targeting and phosphoinositide binding.

  15. APPL proteins exert their stimulatory effects on beta-catenin/TCF-dependent transcription by decreasing the activity of a Reptin-containing repressive complex

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. APPL2 overexpression could blunt the activation of glucocorticoid receptor when undergoing environmental stress.

  2. Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4-induced signaling, transcription, and cytokine secretion.

  3. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF-induced Akt activation, migration, and invasion.

  4. Rab31, with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Antigen Profile

Protein Summary

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) antibody
  • APPL2 antibody
  • Dip3b antibody
  • DIP13B antibody
  • MGC84621 antibody
  • RGD1563028 antibody

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
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