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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway.

5 results:

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-664) protein (His tag) Protein

APPL2 Origin: Human Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3078974
$10,223.08
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 60 Business Days
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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-662) protein (His tag) Protein

APPL2 Origin: Mouse Source: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. Crys, ELISA, SDS, WB
Catalog No. ABIN3126402
$10,223.08
Plus shipping costs $45.00 and $24.00 dry ice
1 mg (More quantities available)
local_shipping Shipping to: United States
Will be delivered in 60 Business Days
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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-664) protein (GST tag) Protein

APPL2 Origin: Human Source: Wheat germ Recombinant AA, AP, ELISA, WB
Catalog No. ABIN1345410
$414.29
Plus shipping costs $45.00 and $24.00 dry ice
10 μg (More quantities available)
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days
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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 174-273) protein (GST tag) Protein

APPL2 Origin: Human Source: Wheat germ Recombinant AA, AP, ELISA, WB
Catalog No. ABIN1345412
$414.29
Plus shipping costs $45.00 and $24.00 dry ice
10 μg (More quantities available)
local_shipping Shipping to: United States
Delivery in 11 to 12 Business Days
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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) protein (Myc-DYKDDDDK Tag) Protein

APPL2 Origin: Human Source: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, Func, PI, STD
Catalog No. ABIN2714848
$888.80
Plus shipping costs $45.00 and $24.00 dry ice
20 μg
local_shipping Shipping to: United States
Will be delivered in 11 Business Days
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  • Type Protein
    • Protein
  • Target Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2)
    • Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2)
    • Hemagglutinin (HA)
    • Ribosome Binding Factor A (RBFA)
    • Tumor Necrosis Factor alpha (TNF)
    • S-Adenosyl-Methionine Synthase (METK)
    • Interleukin 6 (IL6)
    • Interferon gamma (IFNG)
    • Hemoglobin beta (HBB)
    • Triosephosphate Isomerase 1 (TPI1)
    • Thymidylate Kinase (Tmk)
    • Interleukin 4 (IL4)
    • Interleukin 1, beta (IL1B)
    • Interleukin 2 (IL2)
    • Uracil-DNA Glycosylase (UNG)
    • Growth Hormone 1 (GH1)
    • Fibroblast Growth Factor 2 (Basic) (FGF2)
    • Lipoyl synthase lipA
    • Interleukin 10 (IL10)
    • KIT Ligand (KITLG)
    • Malate Dehydrogenase (MDH)
    • Insulin-Like Growth Factor 1 (IGF1)
    • Epidermal Growth Factor (EGF)
    • Leptin (LEP)
    • Interleukin 8 (IL8)
    • Interleukin 3 (IL-3)
    • Myoglobin (MB)
    • Queuine tRNA-Ribosyltransferase 1 (QTRT1)
    • serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1)
    • Hemoglobin, alpha 1 (HBA1)
    • phosphatidylserine Decarboxylase (PISD)
    • Interleukin 1 alpha (IL1A)
    • Prolactin (PRL)
    • Interleukin 13 (IL13)
    • CD40 Ligand (CD40LG)
    • Vascular Endothelial Growth Factor A (VEGFA)
    • Chemokine (C-X-C Motif) Ligand 12 (CXCL12)
    • Albumin (ALB)
    • Aspartate Carbamoyltransferase (PYRB)
    • Phosphoglucosamine Mutase (GLMM)
    • Interleukin 15 (IL15)
    • Porphobilinogen Deaminase (HEMC)
    • beta-2-Microglobulin (B2M)
    • Phenylalanyl-tRNA Synthetase, alpha Subunit (FARSA)
    • Chemokine (C-C Motif) Ligand 2 (CCL2)
    • Gp120
    • Adiponectin (ADIPOQ)
    • Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2)
    • Cytidine Monophosphate (UMP-CMP) Kinase 1, Cytosolic (CMPK1)
    • Fibroblast Growth Factor 1 (Acidic) (FGF1)
    • Interleukin 33 (IL33)
    • Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1)
  • Application
    • ELISA
    • Western Blotting (WB)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • SDS-PAGE (SDS)
    • Crystallization (Crys)
    • Antibody Production (AbP)
    • Functional Studies (Func)
    • Protein Interaction (PI)
    • Standard (STD)
  • Reactivity
    • Human
    • Mouse
  • Images available
  • Host
    • Insect Cells
    • Wheat germ
    • HEK-293 Cells
  • Binding Specificity
    • AA 1-664
    • AA 1-662
    • AA 174-273
  • Conjugate
    • Un-conjugated
    • GST tag
    • His tag
    • Myc-DYKDDDDK Tag
  • Protein Type
    • Recombinant
  • Format
    • Liquid

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Protein Profile

Protein Summary

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) antibody
  • adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) antibody
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) antibody
  • APPL2 antibody
  • Dip3b antibody
  • DIP13B antibody
  • MGC84621 antibody
  • RGD1563028 antibody

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus

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