Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins
The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway.
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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-664) protein (His tag) Protein
Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-662) protein (His tag) Protein
Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 1-664) protein (GST tag) Protein
Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) (AA 174-273) protein (GST tag) Protein
Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) protein (Myc-DYKDDDDK Tag) Protein
Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Protein Profile
Protein Summary
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
Gene names and symbols associated with APPL2
- adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) antibody
- adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) antibody
- adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) antibody
- adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) antibody
- adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) antibody
- adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) antibody
- APPL2 antibody
- Dip3b antibody
- DIP13B antibody
- MGC84621 antibody
- RGD1563028 antibody
Protein level used designations for APPL2
DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta
GENE ID | SPECIES |
---|---|
362860 | Rattus norvegicus |
418075 | Gallus gallus |
447596 | Xenopus laevis |
515605 | Bos taurus |
100000135 | Danio rerio |
100127202 | Xenopus (Silurana) tropicalis |
100545199 | Meleagris gallopavo |
100563730 | Anolis carolinensis |
100604575 | Nomascus leucogenys |
55198 | Homo sapiens |
216190 | Mus musculus |
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