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APPL2 Proteins

(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].

recommended

APPL2 Protein (AA 403-664) (His tag) (ABIN7121696)

APPL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB

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recommended

APPL2 Protein (AA 1-664) (GST tag) (ABIN1345410)

APPL2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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recommended

APPL2 Protein (AA 174-273) (GST tag) (ABIN1345412)

APPL2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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APPL2 Proteins by Grade

Find APPL2 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

APPL2 Proteins by Origin

Find APPL2 Proteins for a variety of species such as anti-Human APPL2, anti-Mouse APPL2. The species listed below are among those available. Click on a link to go to the corresponding products.

APPL2 Proteins by Source

Here you will find APPL2 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

APPL2 Proteins by Protein Type

Here you can find APPL2 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

APPL2 Proteins by Application

Find APPL2 Proteins validated for a specific application such as ELISA, WB, AP, AA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular APPL2 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

APPL2 Protein (AA 403-664) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7121696

Quantity 50 μg

Datasheet Datasheet

APPL2 Protein (AA 1-664) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1345410

Quantity 10 μg

Datasheet Datasheet

APPL2 Protein (AA 174-273) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1345412

Quantity 10 μg

Datasheet Datasheet

APPL2 Protein (AA 1-664) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3078974

Quantity 1 mg

Datasheet Datasheet

APPL2 Protein (AA 1-662) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3126402

Quantity 1 mg

Datasheet Datasheet

APPL2 Protein (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2714848

Quantity 20 μg

Datasheet Datasheet

Aliases for APPL2 Proteins

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2) Proteins
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2) Proteins
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L) Proteins
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2) Proteins
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2) Proteins
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2) Proteins
APPL2 Proteins
Dip3b Proteins
dip13b Proteins
DIP13B Proteins
MGC84621 Proteins
RGD1563028 Proteins

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APPL2 Proteins by Grade

APPL2 Proteins by Origin

APPL2 Proteins by Source

APPL2 Proteins by Protein Type

APPL2 Proteins by Application

Popular APPL2 Proteins

Aliases for APPL2 Proteins

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