anti-Adiponectin (ADIPOQ) Antibodies

Human Adiponectin (ADIPOQ) interaction partners

1. ADIPOQ gene SNP rs182052 was associated with antipsychotic-induced weight gain.

2. the current study indicated that the adiponectin expression levels were higher in the osteoarthritis patients than in the healthy controls.

3. Serum total adiponectin and gender-specific ADIPOQ variants predict CHD (show CHDH Antibodies) and IS, but not HF, independently of other risk factors in community-based patients with T2D.

4. severely obese patients, adiponectin gene expression in visceral adipose tissue (VAT) is negatively correlated with serum levels of uric acid and is an independent determinant, together with anthropometric parameters of visceral obesity and serum adiponectin levels, of insulin (show INS Antibodies) resistance.

5. Adiponectin and colon cancer: evidence for inhibitory effects on viability and migration of human colorectal cell lines.

6. Studied the association of SNPs in the adiponectin gene with coronary artery disease in 277 Tunisian patients with angiographically confirmed coronary artery disease.

7. Increased cardiovascular disease risk is associated with ADIPOQ SNPs, rs266729 and rs2241766, but not associated with rs1501299 (meta-analysis).

8. High ADIPOQ expression is associated with hypothyroidism.

9. adiponectin 45T/G polymorphism is associated with diabetic cardiovascular complication in type 2 diabetes

10. preoperative adiponectin levels correlate with postoperative complications after cancer surgery

Mouse (Murine) Adiponectin (ADIPOQ) interaction partners

1. miR-711, which is upregulated by Adipoq, represses TLR4 signaling, acting therefore as a major mediator of the anti-inflammatory action of Adipoq.

2. both paracrine and endocrine effects of adiponectin may contribute to reduced reactive oxygen species generation and apoptosis after MI/R, in a CD36 (show CD36 Antibodies)-dependent manner

3. These data may indicate that insulin (show INS Antibodies) resistance in Adp(-/-) mice is likely caused by an increase in concentrations of TNFalpha (show TNF Antibodies) and FFA via downregulation of PPARalpha (show PPARA Antibodies).

4. Adiponectin improves metabolic health but has only minor effects on reproductive functions in the polycystic ovary syndromemouse model.

5. APN attenuates adverse cardiac remodeling following cardiac injury by up-regulating MMP-9 expression. APN up-regulates MMP-9 expression via activation of AMPK and ERK1/2.

6. the effects of APN (show ANPEP Antibodies) on the promotion of preadipocyte differentiation under inflammatory conditions may involve the PPARgamma (show PPARG Antibodies) signaling pathway, and at least partly depends on upregulation of PPARgamma (show PPARG Antibodies) expression.

7. Results demonstrate that adiponectin enhances inhibitory postsynaptic current onto neuropeptide Y (NPY (show NPY Antibodies)) neurons to attenuate action potential firing in NPY (show NPY Antibodies) neurons in a glucose-independent manner, being contrasted to its glucose-dependent effect on proopiomelanocortin (show POMC Antibodies) neurons.

8. Results show a reciprocal regulation of adiponectin and FGF19 (show FGF19 Antibodies) gene expression in mice.

9. Acrp30 (a globular form of adiponectin) reduces the expression of proinflammatory cytokines and the expression of RAGE (show AGER Antibodies) as beta amyloid transporters into brain. Moreover, Acrp30 attenuated the apoptosis and the tight junction disruption through AdipoR1 (show ADIPOR1 Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) pathway in beta amyloid-exposed bEnd.3 cells.

10. Findings demonstrate that adiponectin is an essential regulator of thermogenesis, and adiponectin is required for maintaining body temperature under cold exposure.

Pig (Porcine) Adiponectin (ADIPOQ) interaction partners

1. Adiponectin affects development of porcine uterine epithelia and reproductive performance through modulation of PI3K/AKT (show AKT1 Antibodies) and MAPK (show MAPK1 Antibodies) cell signaling pathway.

2. Results presented in this study indicate the modulatory effect of P4 on adiponectin system in the porcine uterus during early pregnancy, which may suggest the involvement of this adipokine in the early pregnancy establishment.

3. The fluctuations in adiponectin and orexin (show OX Antibodies) concentrations in the plasma and uterine lining fluid (ULF (show TRIP12 Antibodies)) suggest that the hormones present in ULF (show TRIP12 Antibodies) are mostly of local origin and that these hormones participate in the processes that accompany early pregnancy.

4. This study demonstrated the presence of adiponectin and its receptors in the uteri, conceptuses, and trophoblasts of pregnant pigs and that the local adiponectin system is dependent on the stage of pregnancy.

5. It was concluded that the recombinant ADPN (show PNPLA3 Antibodies) could express in eukaryotic expression vector pPICZaA-ADPN (show PNPLA3 Antibodies) constructed in this study.

6. study demonstrated that adiponectin and adiponectin receptors 1 and 2 messenger RNAs and proteins are present in the porcine hypothalamus and that their expression levels are determined by the pig's endocrine status related to the oestrous cycle

7. This study demonstrated the presence of adiponectin, AdipoR1 and AdipoR2 genes and proteins in the porcine uterus and the effect of the stage of the oestrous cycle on the expression of the adiponectin system.

8. inhibition of ADIPOQ gene changes the mRNA levels of the adipocyte differentiation transcription factors LPL (show LPL Antibodies), PPARgamma (show PPARG Antibodies) and AP2 (show TFAP2B Antibodies).

9. Myocardial ADN (show CFD Antibodies) was reduced in dilated cardiomyopathy in an AMPK (show PRKAA1 Antibodies)-independent manner.

10. Results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44, which in turn controls the secretion of adiponectin.

Cow (Bovine) Adiponectin (ADIPOQ) interaction partners

1. These data suggest that energy balance around parturition may regulate plasma adiponectin but do not support roles for lipid mobilization or sustained changes in the plasma concentration of leptin, insulin, growth hormone, or fatty acids.

2. Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 (show ADIPOR1 Antibodies) and AdipoR2 (show ADIPOR2 Antibodies) mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.

3. Data suggest that genetic variation in promoter region of ADIPOQ (SNPs g.81966235C>T, g.81966377T>C, and g.81966364D>I) contribute to adiposity/marbling in skeletal muscle/meat (and thus meat quality) of Hanwoo beef cattle of North Korea.

4. These data suggest differential contribution of adipose tissue depots to circulating adiponectin.

5. Association analysis indicated that variable duplication within the ADIPOQ gene is associated with body measurements.

6. 14 polymorphisms of the ADIPOQ gene were observed in Chinese cattle; 2 polymorphisms PR_-135 A>G and PR_-68 G>C were located in the core promoter region of ADIPOQ; 3 haplotypes in the 2 polymorphic sites were detected which produce effects on ADIPOQ transcription and are associated with growth traits

7. reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin (show INS Antibodies) resistance

8. The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.

9. The disulfide bonds help to maintain the mature octadecameric adiponectin structure and stabilize intermediates during the assembly.

10. Gobular adiponectin increased NO production in aortic endothlium by increasing NO synthase activity.

Zebrafish Adiponectin (ADIPOQ) interaction partners

1. Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation

Rabbit Adiponectin (ADIPOQ) interaction partners

1. Data suggest that, in blastocysts developing under maternal diabetic conditions which includes hyperadiponectinemia, p38 MAPK (show MAPK14 Antibodies) is up-regulated compared to control; however, in blastocysts cultured in vitro with excess adiponectin, p38 MAPK (show MAPK14 Antibodies) is not up-regulated.

2. Adiponectin level partially reflects the severity of liver steatosis, but not the degree of liver inflammation.