anti-Adiponectin (ADIPOQ) Antibodies

Human Adiponectin (ADIPOQ) interaction partners

1. Hypoadiponectinemia and rising PAI-1 over time are early features of the cardiometabolic biomarker profile of women with recent gestational dysglycemia.

2. data suggest that the more favorable lipoprotein profile as associated with elevated NT-proBNP concentrations in mainly cardiac healthy individuals might relate to adiponectin signaling indicating even indirect cardio-protective effects for NT-proBNP.

3. Decreased APN level at admission might be associated with poststroke depression in patients after acute ischemic stroke.

4. in this study, exome sequencing revealed C1Q homozygous mutation in pediatric systemic lupus erythematosus

5. findings suggest that omentin-1, rather than adiponectin, could be useful as a predictor of preterm birth in patients with gestational diabetes mellitus.

6. A high serum adiponectin level is independently associated with a low hemoglobin level and predicts the development of anemia in patients with chronic kidney disease (CKD). These findings reveal the potential role of adiponectin in CKD-related anemia.

7. We provide evidence that H19 and ADIPOQ are expressed inconsistently in paravertebral muscles, and more importantly, lower H19 levels and higher ADIPOQ levels in concave-sided muscle tissues positively correlate with spinal curve and age at initiation. These data suggest an important role of H19 and ADIPOQ in the onset or progression of scoliosis.

8. patients with OSA have decreased omentin levels, which are associated with sleep parameters, including AHI, SpO2, percentage of REM sleep, hsCRP, HDL, and adiponectin levels.

9. Data suggest that, although changes in the plasma adiponectin/leptin ratio cannot explain improvements to glucose-insulin homeostasis indices following moderate-intensity aerobic training (16-week brisk walking program), a relationship with insulin sensitivity does exist in healthy women with obesity.

10. Our findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of polycystic ovary syndrome in certain ethnicities.

11. Adiponectin levels below the indicated cut-offs may predict a potential risk for the development of insulin resistance.

12. Maternal serum and/or breast milk adiponectin was associated with first-year infant adiposity development.

13. Significant combined effects of obesity and the adiponectin rs182052 G/A+A/A genotype, were found to be a risk for arsenic-related renal cell carcinoma.

14. Serum adiponectin correlates negatively with bone density in type 2 diabetic osteoporotic postmenopausal women.

15. The 276G gene of adiponectin may be a susceptibility gene of CHD, and the genotype GG may be related to the severity of this disease.

16. Alongside insulin resistance, increased sympathetic activity is associated with and may modulate HMW adiponectin levels in women with polycystic ovary syndrome.

17. The adiponectin +276G/T polymorphism may be associated with the development of Kawasaki disease.

18. Genetic polymorphisms in the adiponectin gene of recipients (but not donors) are associated with early de novo posttransplant hepatic steatosis.

19. Expression of adiponectin inhibit the proliferation of colorectal cancer HCT116 cells and induce cell arrest at G1/G0 phase and promote apoptosis.

20. Adiponectin was negatively related only in obese subjects

Mouse (Murine) Adiponectin (ADIPOQ) interaction partners

1. glycine exposure enhanced the mRNA levels of adipose-derived adiponectin and IL-10 without affecting adipogenesis and lipolysis in 3T3-L1 adipocytes.

2. acute depletion of APN is especially detrimental to lipid homeostasis, both under basal and insulinopenic conditions

3. These data suggest that APN has a moderate regulatory role in oxidative stress-induced mitophagy and suppresses apoptosis. These findings demonstrate the antioxidant potential of APN in oxidative stress-associated skeletal muscle diseases.

4. Downregulation of adiponectin in inflamed adipocyte by fetuin-A through the mediation of Wnt3a and PPARgamma is a new report.

5. Study results indicate for the first time that adiponectin is able to influence the mechanical responses in strips from the mouse gastric fundus.

6. miR-711, which is upregulated by Adipoq, represses TLR4 signaling, acting therefore as a major mediator of the anti-inflammatory action of Adipoq.

7. both paracrine and endocrine effects of adiponectin may contribute to reduced reactive oxygen species generation and apoptosis after MI/R, in a CD36-dependent manner

8. These data may indicate that insulin resistance in Adp(-/-) mice is likely caused by an increase in concentrations of TNFalpha and FFA via downregulation of PPARalpha.

9. Adiponectin improves metabolic health but has only minor effects on reproductive functions in the polycystic ovary syndromemouse model.

10. APN attenuates adverse cardiac remodeling following cardiac injury by up-regulating MMP-9 expression. APN up-regulates MMP-9 expression via activation of AMPK and ERK1/2.

11. the effects of APN on the promotion of preadipocyte differentiation under inflammatory conditions may involve the PPARgamma signaling pathway, and at least partly depends on upregulation of PPARgamma expression.

12. Results demonstrate that adiponectin enhances inhibitory postsynaptic current onto neuropeptide Y (NPY) neurons to attenuate action potential firing in NPY neurons in a glucose-independent manner, being contrasted to its glucose-dependent effect on proopiomelanocortin neurons.

13. Results show a reciprocal regulation of adiponectin and FGF19 gene expression in mice.

14. Acrp30 (a globular form of adiponectin) reduces the expression of proinflammatory cytokines and the expression of RAGE as beta amyloid transporters into brain. Moreover, Acrp30 attenuated the apoptosis and the tight junction disruption through AdipoR1-mediated NF-kappaB pathway in beta amyloid-exposed bEnd.3 cells.

15. Findings demonstrate that adiponectin is an essential regulator of thermogenesis, and adiponectin is required for maintaining body temperature under cold exposure.

16. Chronic stress accelerates DPP4-mediated GLP-1 degradation and alters plasma adiponectin, accelerating vascular senescence and impairing ischemia-induced neovascularization.

17. AdipoQ antisense (AS) Long noncoding RNA (lncRNA) transfer from nucleus to cytoplasm inhibits adipogenesis through formation of an AdipoQ AS lncRNA/AdipoQ mRNA duplex to suppress the translation of AdipoQ mRNA.[

18. Adiponectin enhances quiescence exit of murine hematopoietic stem cells and hematopoietic recovery through mTORC1 potentiation.

19. plasma adiponectin and leptin were also decreased in IL 10tm.These findings suggest that frailty observed in this mouse model of chronic inflammation may in part be driven by alterations in fat mass, hormone secretion and energy metabolism

20. CpG ODNs decreased placental adiponectin expression in NOD mice and impaired human trophoblast function and was associated with increased embryo loss. Adiponectin may therefore play an important protective role in the prevention of bacteria-induced pregnancy failure.

Pig (Porcine) Adiponectin (ADIPOQ) interaction partners

1. Adiponectin affects development of porcine uterine epithelia and reproductive performance through modulation of PI3K/AKT and MAPK cell signaling pathway.

2. Results presented in this study indicate the modulatory effect of P4 on adiponectin system in the porcine uterus during early pregnancy, which may suggest the involvement of this adipokine in the early pregnancy establishment.

3. The fluctuations in adiponectin and orexin concentrations in the plasma and uterine lining fluid (ULF) suggest that the hormones present in ULF are mostly of local origin and that these hormones participate in the processes that accompany early pregnancy.

4. This study demonstrated the presence of adiponectin and its receptors in the uteri, conceptuses, and trophoblasts of pregnant pigs and that the local adiponectin system is dependent on the stage of pregnancy.

5. It was concluded that the recombinant ADPN could express in eukaryotic expression vector pPICZaA-ADPN constructed in this study.

6. study demonstrated that adiponectin and adiponectin receptors 1 and 2 messenger RNAs and proteins are present in the porcine hypothalamus and that their expression levels are determined by the pig's endocrine status related to the oestrous cycle

7. This study demonstrated the presence of adiponectin, AdipoR1 and AdipoR2 genes and proteins in the porcine uterus and the effect of the stage of the oestrous cycle on the expression of the adiponectin system.

8. inhibition of ADIPOQ gene changes the mRNA levels of the adipocyte differentiation transcription factors LPL, PPARgamma and AP2.

9. Myocardial ADN was reduced in dilated cardiomyopathy in an AMPK-independent manner.

10. Results indicated that PPARgamma is an essential regulatory factor for the transcriptional activity of ERp44, which in turn controls the secretion of adiponectin.

11. Adiponectin differentially regulates cytokines in porcine macrophages

12. The cloning and characterization of adiponectin, ADIPOR1, and ADIPOR2 are reported.

13. Insulin regulates the expression of adiponectin and adiponectin receptors in porcine adipocytes.

14. SNPs and haplotypes that are associated with large litter size, fewer stillborn and mummified piglets and shorter weaning-to-oestrus intervals.

15. Adiponectin expression is correlated with the "fat" phenotype in pig.

16. To understand the regulatory expression of pig adiponectin, the 5'-flanking region of the adiponectin gene was isolated from a pig BAC library. 5'-RACE analysis revealed that there were three transcriptional start sites, including one that is novel.

17. The results suggested that the methylation of adiponectin promoter experienced a dynamic process, with the development of individuals, which agreed with the fluctuating trend of gene expression.

Cow (Bovine) Adiponectin (ADIPOQ) interaction partners

1. These data suggest that energy balance around parturition may regulate plasma adiponectin but do not support roles for lipid mobilization or sustained changes in the plasma concentration of leptin, insulin, growth hormone, or fatty acids.

2. Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 and AdipoR2 mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.

3. Data suggest that genetic variation in promoter region of ADIPOQ (SNPs g.81966235C>T, g.81966377T>C, and g.81966364D>I) contribute to adiposity/marbling in skeletal muscle/meat (and thus meat quality) of Hanwoo beef cattle of North Korea.

4. These data suggest differential contribution of adipose tissue depots to circulating adiponectin.

5. Association analysis indicated that variable duplication within the ADIPOQ gene is associated with body measurements.

6. 14 polymorphisms of the ADIPOQ gene were observed in Chinese cattle; 2 polymorphisms PR_-135 A>G and PR_-68 G>C were located in the core promoter region of ADIPOQ; 3 haplotypes in the 2 polymorphic sites were detected which produce effects on ADIPOQ transcription and are associated with growth traits

7. reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin resistance

8. The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.

9. The disulfide bonds help to maintain the mature octadecameric adiponectin structure and stabilize intermediates during the assembly.

10. Gobular adiponectin increased NO production in aortic endothlium by increasing NO synthase activity.

11. A 5bp deletion mutation within the bovine ACRP30 gene was firstly detected and confirmed in 991 cattle .

12. results indicate decreasing adiponectin sensitivity in adipose tissue after calving which might be involved in the reduced insulin sensitivity of adipose tissue during lactation

13. Adiponectin gene was proved to be closely related to carcass and meat quality traits (P < 0.05), which can be used as a candidate molecular marker for production of high-grade meat in Qinchuan beef cattle.

Zebrafish Adiponectin (ADIPOQ) interaction partners

1. Adiponectin and adiponectin receptor genes are coexpressed during zebrafish embryogenesis and regulated by food deprivation

Rabbit Adiponectin (ADIPOQ) interaction partners

1. Data suggest that, in blastocysts developing under maternal diabetic conditions which includes hyperadiponectinemia, p38 MAPK is up-regulated compared to control; however, in blastocysts cultured in vitro with excess adiponectin, p38 MAPK is not up-regulated.

2. Adiponectin level partially reflects the severity of liver steatosis, but not the degree of liver inflammation.