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ARMS2 encodes a protein that is thought to play a role in diseases in the elderly. Additionally we are shipping ARMS2 Antibodies (20) and ARMS2 Kits (1) and many more products for this protein.
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In polypoidal choroidal vasculopathy patients, ARMS2 rs10490924 showed association with anatomic therapeutic response to anti-VEGF (show VEGFA Proteins), suggesting pharmacogenetic relationship.
The ARMS2 A69S polymorphism was associated with CNV recurrence rate in our patient cohort. Prediction of a greater risk of recurrence could help to design more appropriate follow-up treatment strategies for patients with neovascular AMD (show AMD1 Proteins).
Complement factor H (show CFH Proteins) Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (Meta-Analysis).
The present meta-analysis revealed that the ARMS2 A69S risk variants confer a significantly greater risk of retinal angiomatous proliferation compared with neovascular age-related macular degeneration.
we speculate that up-regulation of leptin (show LEP Proteins) and ARMS2 forms part of an important survival mechanism to compensate for placental growth discordance in monochorionic diamniotic twin pregnancies
This analysis revealed the synergistic effect of these two factors indicating that there is a common pathway of ARMS2/LOC387715 and smoking in AMD (show AMD1 Proteins) pathogenesis which may be the complement system pathway.
The findings of the present study provide evidence that CFH (show CFH Proteins) gene variants and ARMS2/HTRA1 (show HTRA1 Proteins) genes play a major role in the genetic susceptibility to AMD (show AMD1 Proteins) in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD (show AMD1 Proteins).
Development of polypoidal choroidal vasculopathy (PCV) in the unaffected fellow eye is associated with ARMS2 A69S genotype in patients with unilateral PCV.
OCT (show Plxna2 Proteins) scans revealed lower retinal thickness in patients homozygous for CFH (show CFH Proteins) or ARMS2, which was caused by a significantly reduced photoreceptor layer. The number and ultrastructure of drusen were also significantly different.
This study suggests that in familial age-related macular degeneration patients, the common genetic risk variant in ARMS2 is less important compared to sporadic age-related macular degeneration.
This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration.
age-related maculopathy susceptibility protein 2
, age-related maculopathy susceptibility 2