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The protein encoded by ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. Additionally we are shipping ALDH1L1 Antibodies (131) and ALDH1L1 Proteins (4) and many more products for this protein.
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Our results suggest that ALDH1L1 may be a biomarker for predicting postoperative clinical outcomes. Moreover, ALDH1L1-rs2276724 and mRNA expression were associated with TP53 expression in HBV-related hepatocellular carcinoma patients
ALDH1L1 has a role in response to the combined treatment of gossypol and phenformin in non-small cell lung cancer
high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients
The three functional domains of ALDH1L1 was defined positions of the 4'-phosphopantetheine arm within the two catalytic domains and to predict N-terminal:intermediate and intermediate:C-terminal domain interfaces.
The polymorphic loci rs4646733, rs2305225, and rs2276731 in the ALDH1L1 gene maybe potential risk factors for neural tube defects in the Chinese population.
Data suggest that isoforms of FTHFD occur both in mitochondria and in cytosol; activity of cytosolic FTHFD appears to respond to supply of one-carbon groups in excess of those required for classical one-carbon metabolism. [REVIEW]
JNK1/2 phosphorylate Bid at Thr59 within the caspase cleavage site in response to ALDH1L1.
ALDH1 is indicative of stemness and is a biomarker marker in colon cancer.
one variant in the ALDH1L1 locus, rs2364368, was associated with incident ischemic stroke.
The results in this study, for the first time, reveal that the mRNA and protein expressions of ALDH1L1 are significantly reduced in hepatocellular carcinoma tissues
Conserved catalytic residues of the ALDH1L1 aldehyde dehydrogenase domain control binding and discharging of the coenzyme.
These studies support ALDH1L1 as a general CNS astroglial marker.
inhibition of cell motility by ALDH1L1 associated with dephosphorylation of the actin depolymerizing factor cofilin by PP1 and PP2A
down-regulation of FDH in tumors is proposed to be one of the cellular mechanisms that enhance proliferation.
FDH antiproliferative effects on A549 cells include both G(1) cell cycle arrest and caspase-dependent apoptosis
None of the snps that defined 3 separate haplotype blocks in the FTHFD gene, rs2365004, rs11923466, rs2886059, rs10934751, rs2276731, rs1823213 and rs4646701 were associated with prostate cancer risk.
Collectively, MNSFbeta/FDH complex formation may positively regulate apoptosis in thymocytes.
Aldh1L1 is not a suitable marker for enteric glial cells.
This study demonistrated that Aldh1L1 is expressed by postnatal neural stem cells in mice.
These data provide the first evidence for localized differences in folate metabolism within the early neural tube and suggest that folate might modulate proliferation via effects on midline Aldh1l1(+) cells.
The crystal structures of apo-form N-terminal domain - FDH and its complexes with the substrate analogue 10-formyl-5,8-dideazafolate (10-FDDF) and with the products tetrahydrofolate and formate have been determined.
Knock-down of the fdh(10-Formyltetrahydrofolate dehydrogenase) gene impeded morphogenetic movement and caused incorrect cardiac positioning, defective hematopoiesis, notochord malformation and ultimate death of morphants
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
, cytosolic 10-formyltetrahydrofolate dehydrogenase
, aldehyde dehydrogenase family 1 member L1
, formyltetrahydrofolate dehydrogenase
, aldehyde dehydrogenase 1L1
, aldehyde dehydrogenase 1 family, member L1
, 10-formyltetrahydrofolate dehydrogenase-like