anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Antibodies

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping Aldehyde Dehydrogenase 2 Family (Mitochondrial) Kits (21) and Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALDH2 217 P05091
ALDH2 29539 P11884
ALDH2 11669 P47738
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Top anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies at

Showing 10 out of 179 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit  Target Name: Aldh2  Sample Tissue: Mouse Small Intestine lysates  Antibody Dilution: 1.0 µg/mL 100 μL 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB Anti- ALDH2 Picoband antibody, IHC(P) IHC(P): Human Kidney Cancer Tissue Anti- ALDH2 Picoband antibody, Western blotting All lanes: Anti ALDH2  at 0.5ug/ml Lane 1: Rat Kidney Tissue Lysate at 50ug Lane 2: Mouse Kidney Tissue Lysate at 50ug Predicted bind size: 56KD Observed bind size: 56KD 100 μg 4 to 6 Days
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB 0.1 mg 3 to 4 Days
Human Goat Un-conjugated ELISA, EIA, WB   100 μg 6 to 7 Days
Mouse Rabbit Un-conjugated IHC, WB Immunofluorescence analysis of A549 cell using ALDH2 antibody. Western blot analysis of extracts of various cell lines, using ALDH2 antibody. 100 μL 13 to 14 Days
Human Rabbit Un-conjugated IHC (p), WB Anti-ALDH2 antibody, IHC(P) IHC(P): Human Liver Cancer Tissue Anti-ALDH2 antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Intestine Tissue Lysate Lane 3: Rat Lung Tissue Lysate Lane 4: Rat Kidney Tissue Lysate 100 μg 4 to 6 Days
Human Rabbit Un-conjugated IHC, WB 100 μL 2 to 3 Days
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse Muscle, antibody was diluted at 1:100. 100 μL Available
Human Mouse Un-conjugated ELISA, FACS, IF/ICC, IHC, WB 100 μg 11 to 16 Days
Human Rabbit Un-conjugated WB Western blot analysis of ALDH2 expression in HegG2 (A), A549 (B) whole cell lysates. 200 μL 13 to 14 Days

Top referenced anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies

  1. Human Monoclonal ALDH2 Primary Antibody for ELISA, WB - ABIN513240 : Jeon, Jeong, Baek, Koo, Park, Yang, Yu, Kim, Pak: Network clustering revealed the systemic alterations of mitochondrial protein expression. in PLoS computational biology 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal ALDH2 Primary Antibody for ICC, FACS - ABIN1724795 : Zhang, Gong, Zhang, Li, Hu: Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease. in European heart journal 2012 (PubMed)
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  3. Mouse (Murine) Polyclonal ALDH2 Primary Antibody for IHC, WB - ABIN3021779 : Yan, Lestari, Long, Fan, Wang, Guo, Yu, Hu, Yang, Chen, Liu, Li, Purnomoadi, Achmadi, Yan: Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells. in Scientific reports 2017 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal ALDH2 Primary Antibody for IHC, WB - ABIN6672689 : Long, Muhamad, Yan, Yu, Fan, Wang, Li, Purnomoadi, Achmadi, Yan: Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells. in Amino acids 2017 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal ALDH2 Primary Antibody for ELISA, EIA - ABIN4279257 : Kimura, Sawayama, Matsushita, Higuchi, Kashima: Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics. in Alcoholism, clinical and experimental research 2009 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal ALDH2 Primary Antibody for ICC, FACS - ABIN1724796 : Bae, Kim, Shin, Kim, Shin, Kim, Kim, Yoon: The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes. in Clinical toxicology (Philadelphia, Pa.) 2012 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal ALDH2 Primary Antibody for FACS, IF - ABIN2715915 : Qiang, Xiao, Su, Wu, Tong, Liu, He: A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse. in Journal of Alzheimer's disease : JAD 2014 (PubMed)

More Antibodies against Aldehyde Dehydrogenase 2 Family (Mitochondrial) Interaction Partners

Rabbit Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH-2 is involved in the remote ischemic preconditioning pathway.

Human Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2*2 genotype is prevalent among East Asians and is a significant risk factor for both coronary spasm and Acute Myocardial Infarction (Review)

  2. ALDH2 mutation combined with heavy alcohol consumption, suggesting a genetic-environmental interaction in carcinogenesis (Review)

  3. These results suggested that ALDH2 Glu504Lys variant could predict a worse prognosis of acute coronary syndrome patients.

  4. Studies indicate that A allele carriers of mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) gene G487A polymorphism may be particularly susceptible to coronary artery disease (CAD) [Meta-analysis].

  5. The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder.

  6. These data shed new light on the association between genetic polymorphisms of ALDH2 and LDH susceptibility in a Chinese Han population.

  7. The combination of ADH1B*1/*1 and ALDH2*1/*2 markedly increased the risk of esophageal distinct iodine-unstained lesions (DIULs) >/=5 mm (39.3 [10.6-146]). Japanese alcohol-dependent women shared several common risk factors for esophageal squamous cell neoplasia with alcohol-dependent men, but with considerably different magnitudes.

  8. Inactive ALDH2 was negatively correlated with alcohol use problems.

  9. ALDH2 rs671 is associated with hypertension and blood cholesterol level in Chinese population.

  10. Lower expression of ALDH2 is associated with cancer.

  11. Acetaldehyde levels and genotype of its metabolizing enzyme, ALDH2, dictate whether acute ethanol/acetaldehyde plays beneficial or detrimental role in ischaemic hearts.

  12. The Rs671 within ALDH2 but not rs1229984 within ADH1B was associated with lower HDL-C levels in Japanese males.

  13. Patients with ALDH2 504lys variant were less associated with alcoholic liver disease compared to those with ALDH2 504glu using both genotypic and allelic analyses.

  14. Our study suggested that ALDH2 rs671 L-genotypes are protective factors for hypertension in Han Chinese. Consumption of fried food accelerated the development of hypertension in individuals with poor metabolism of acetaldehyde.

  15. ALDH2 genotype is associated with the tolerability and side affects to alcohol in paclitaxel in Japanese breast cancer patients.

  16. The ALDH-2 rs671 polymorphism is a protective factor for essential hypertension susceptibility in man and individuals independently of alcohol consumption in Asians.

  17. ALDH2 rs671 polymorphism is associated with the overall cancer risk in Asians (Meta-Analysis)

  18. The results of this study demonstrated that the slow-metabolizing ADH1B Arg/Arg genotype and inactive heterozygous ALDH2 Glu/Lys genotype were positive determinants for the development of fatty liver diagnosed by ultrasonography in alcohol-dependent Japanese men.

  19. Patients with T2DM and mutations in ALDH2 gene had higher levels of formaldehyde and more severe dementia.

  20. Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.

Cow (Bovine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells.

  2. ACADM and ALDH2 were predicted to be the target genes of miR-224

  3. analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2

Mouse (Murine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. studies reveal a novel role of ALDH2 and LDLR in atherosclerosis and provide a molecular mechanism by which ALDH2 rs671 SNP increases CVD.

  2. ALDH2 might be a promising prevention and treatment target for Cyclophosphamide-induced acute cardiotoxicity.

  3. Studied protective role of aldehyde dehydrogenase 2 (ALDH2) in association with signal pathways in high fat diet induced obesity and cardiomyopathy.

  4. esults suggested that ALDH2 may rescue against doxorubicin cardiac toxicity possibly through a TRPV1-mediated protection of mitochondrial integrity.

  5. These results suggested that decrease and deficiency of ALDH2 activity would significantly increase the sensitivity to ETBE-induced genotoxicity as well as hepatotoxic effects after exposure even to low concentrations of ethyl tertiary butyl ether .

  6. ALDH2 deficiency attenuates compensatory cardiac hypertrophy through regulating Akt but not PI3K phosphorylation early after transverse aorta constriction. In vitro, phosphorylation of Akt was significantly accentuated and PTEN expression was reduced while PI3K phosphorylation remained unchanged in stretched cardiomyocytes pretreated by Alda-1 (a small-molecule activator of ALDH2).

  7. data revealed that ALDH2 enzyme may suppress myocardial autophagy possibly through a complex JNK-Bcl-2 and IKKbeta-AMPK-dependent mechanism en route to accentuation of myocardial remodeling and contractile dysfunction in aging.

  8. results thus suggest that ALDH2 is indispensable for the favorable cardiac effect of low-to-moderate alcohol consumption and ALDH2 deficiency may lead to unexpected cardiac dysfunctions via enhancing myocardial apoptosis and necroptosis.

  9. ALDH2 activation improved ethanol-induced cardiac damage and decreased angiotensin and angiotensin II in hearts.

  10. ALDH2 overexpression inhibited the expression of c-Jun N-terminal kinase (JNK)-1, activated protein 1 (AP-1), insulin receptor substrate 1 (IRS-1), 4- hydroxynonenal, caspase 3, transforming growth factor beta1, and collagen I and III, and enhanced Akt phosphorylation.

  11. Study found ALDH2*2 diabetic mice exhibit diastolic dysfunction and preserved systolic function at rest, similar to clinical heart failure of preserved ejection fraction.

  12. ALDH2 deficiency reduced the therapeutic effect of ALDHbr cells in the mice model of ischemic hind limb due to decreased anaerobic glycolysis and increased mitochondrial ROS generation.

  13. osteoblast differentiation is impaired in the absence of Aldh2 gene.

  14. ALDH2 plays a protective role in cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and detoxifying reactive aldehydes.

  15. Deficiency in ALDH2 activity may contribute to increased cisplatin sensitivity and cytotoxicity by producing more ROS by the treatment.

  16. our data suggest that ALDH2 serves as an indispensable cardioprotective factor against insulin resistance-induced cardiomyopathy with a mechanism possibly associated with facilitation of the Sirt3-dependent PGC-1alpha deacetylation.

  17. Findings suggested that ALDH2 can influence atherosclerotic plaque development and vulnerability, and inflammation via MAPK, NF-kappaB and AP-1 signaling pathways.

  18. ALDH2 deficiency triggers decompensation of metabolic reserves and energy metabolism disturbances in early diabetic hearts.

  19. Results show that ALDH2 is required for a normal adipogenesis and its expression in white adipose tissue is negatively correlated with obesity. Also, the study provides evidence that PKCepsilon-ALDH2 pathway positively regulates adipocyte differentiation by regulation of PPARgamma transcriptional activity.

  20. In knock-in mice in which ALDH2 enzymatic activity is maximally reduced, cardio-protection in ischemic-reperfused hearts is lacking.

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Antigen Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ALDH2

  • aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 (aldh2.1) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) L homeolog (aldh2.L) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (aldh2) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2) antibody
  • aldehyde dehydrogenase 2 (aldh2) antibody
  • aldehyde dehydrogenase (RHA1_RS43090) antibody
  • aldehyde dehydrogenase (NAD(+)) (aldH2) antibody
  • hypothetical protein (OE_RS03015) antibody
  • aldehyde dehydrogenase (aldH2) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2) antibody
  • aldehyde dehydrogenase 2, mitochondrial (Aldh2) antibody
  • Ahd-5 antibody
  • Ahd5 antibody
  • ALDH-E2 antibody
  • aldh2 antibody
  • aldh2a antibody
  • ALDHI antibody
  • ALDM antibody
  • MGC80785 antibody
  • rf2b antibody
  • zgc:63786 antibody

Protein level used designations for ALDH2

aldehyde dehydrogenase 2 , aldehyde dehydrogenase 2 family (mitochondrial) , aldehyde dehydrogenase 2 family (mitochondrial)a , aldehyde dehydrogenase 2.1 , mitochondrial aldehyde dehydrogenase 2 , ALDH2B6 , mitochondrial aldehyde dehydrogenase RF2B , aldehyde dehydrogenase , aldehyde dehydrogenase (NAD(+)) , ALDH class 2 , ALDH-E2 , aldehyde dehydrogenase, mitochondrial , aldehyde dehydrogenase, mitochondrial-like , acetaldehyde dehydrogenase 2 , liver mitochondrial ALDH , nucleus-encoded mitochondrial aldehyde dehydrogenase 2 , ALDH1 , aldehyde dehydrogenase 2, mitochondrial , mitochondrial aldehyde dehydrogenase , ALDHI , AHD-M1

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542567 Zea mays
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4226489 Rhodococcus jostii RHA1
5776113 Staphylococcus aureus subsp. aureus USA300_TCH1516
5952690 Halobacterium salinarum R1
9005267 Rhodobacter capsulatus SB 1003
100171596 Pongo abelii
100217978 Taeniopygia guttata
100338523 Oryctolagus cuniculus
100388478 Callithrix jacchus
217 Homo sapiens
29539 Rattus norvegicus
610941 Canis lupus familiaris
733685 Sus scrofa
508629 Bos taurus
416880 Gallus gallus
11669 Mus musculus
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