anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Antibodies

This protein belongs to the aldehyde dehydrogenase family of proteins. Additionally we are shipping Aldehyde Dehydrogenase 2 Family (Mitochondrial) Kits (37) and Aldehyde Dehydrogenase 2 Family (Mitochondrial) Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ALDH2 217 P05091
ALDH2 29539 P11884
ALDH2 11669 P47738
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Top anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies at antibodies-online.com

Showing 10 out of 180 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit  Target Name: Aldh2  Sample Tissue: Mouse Small Intestine lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- ALDH2 Picoband antibody, IHC(P) IHC(P): Human Kidney Cancer Tissue Anti- ALDH2 Picoband antibody, Western blotting All lanes: Anti ALDH2  at 0.5ug/ml Lane 1: Rat Kidney Tissue Lysate at 50ug Lane 2: Mouse Kidney Tissue Lysate at 50ug Predicted bind size: 56KD Observed bind size: 56KD 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of ALDH2 monoclonal antibody  in HepG2 cell line lysates (35ug/lane). ALDH2 (arrow) was detected using the purified mab.(4ug/ml) ALDH2 Monoclonal Antibody  immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.  This data demonstrates the use of the ALDH2 Monoclonal Antibody for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Goat Un-conjugated ELISA, EIA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Mouse Rabbit Un-conjugated IHC, WB Immunofluorescence analysis of A549 cell using ALDH2 antibody. Western blot analysis of extracts of various cell lines, using ALDH2 antibody. 100 μL Log in to see 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-ALDH2 antibody, IHC(P) IHC(P): Human Liver Cancer Tissue Anti-ALDH2 antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Rat Intestine Tissue Lysate Lane 3: Rat Lung Tissue Lysate Lane 4: Rat Kidney Tissue Lysate 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using ALDH2 mAb against human ALDH2 recombinant protein. (Expected MW is 47.4 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse Muscle, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
Details
Human Mouse Un-conjugated ELISA, FACS, IF/ICC, IHC, WB 100 μg Log in to see 11 to 16 Days
$426.40
Details

Top referenced anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) Antibodies

  1. Human Polyclonal ALDH2 Primary Antibody for FACS, IHC (p) - ABIN1881053 : Guo, Wang, Liu, Chen, Qi, Guo: Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. in World journal of gastroenterology : WJG 2008 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal ALDH2 Primary Antibody for ICC, FACS - ABIN1724795 : Zhang, Gong, Zhang, Li, Hu: Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease. in European heart journal 2012 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal ALDH2 Primary Antibody for ICC, FACS - ABIN1724796 : Bae, Kim, Shin, Kim, Shin, Kim, Kim, Yoon: The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes. in Clinical toxicology (Philadelphia, Pa.) 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal ALDH2 Primary Antibody for ELISA, WB - ABIN513240 : Jeon, Jeong, Baek, Koo, Park, Yang, Yu, Kim, Pak: Network clustering revealed the systemic alterations of mitochondrial protein expression. in PLoS computational biology 2011 (PubMed)
    Show all 2 Pubmed References

  5. Mouse (Murine) Polyclonal ALDH2 Primary Antibody for IHC, WB - ABIN3021779 : Yan, Lestari, Long, Fan, Wang, Guo, Yu, Hu, Yang, Chen, Liu, Li, Purnomoadi, Achmadi, Yan: Comparative Proteomics Analysis Reveals L-Arginine Activates Ethanol Degradation Pathways in HepG2 Cells. in Scientific reports 2017 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal ALDH2 Primary Antibody for IHC, WB - ABIN6672689 : Long, Muhamad, Yan, Yu, Fan, Wang, Li, Purnomoadi, Achmadi, Yan: Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid β-oxidation pathway in HepG2 cells. in Amino acids 2017 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal ALDH2 Primary Antibody for IF, WB - ABIN388201 : Duan, Gao, Zhang, Chen, Jiang, Ji, Zhang, Chen, Yang, Su, Zhang, Liu, Zhu, Wang, Yu: Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells against DNA damage caused by oxidative stress. in Free radical biology & medicine 2016 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal ALDH2 Primary Antibody for FACS, IF - ABIN2715915 : Qiang, Xiao, Su, Wu, Tong, Liu, He: A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse. in Journal of Alzheimer's disease : JAD 2014 (PubMed)

  9. Human Polyclonal ALDH2 Primary Antibody for ELISA, EIA - ABIN4279257 : Kimura, Sawayama, Matsushita, Higuchi, Kashima: Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics. in Alcoholism, clinical and experimental research 2009 (PubMed)

More Antibodies against Aldehyde Dehydrogenase 2 Family (Mitochondrial) Interaction Partners

Rabbit Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH-2 is involved in the remote ischemic preconditioning pathway.

Human Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. Patients with T2DM and mutations in ALDH2 gene had higher levels of formaldehyde and more severe dementia.

  2. Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.

  3. the present study suggested that ALDHbr cell counts in the cryopreserved attached segments may serve as a quality assessment indicator for cord blood units prior to umbilical cord blood transplantation.

  4. A significant association between ALDH2 polymorphism (rs671) and gastric cancer risk.A significant interaction between ALDH2 polymorphism and alcohol drinking regarding gastric cancer risk.

  5. Our results highlight that ALDH2 impairment accelerates the acquisition of a premature senescent phenotype, a change likely to be associated with the observed reduction of mitochondrial respiration and reserve capacity.

  6. we identified three novel SNPs associated with ferritin in ALDH2. Men carrying the mutated genotype of rs671 have lower serum ferritin levels.

  7. common variants of ADH1B and ALDH2 are independently associated with gout. Our findings likewise suggest that genotyping these variants can be useful for the evaluation of gout risk.

  8. ALDH2 polymorphism is associated with Gastric and esophageal cancer.

  9. The use of aldehyde dehydrogenase (ALDH) for isolating and identifying sub-populations of mesenchymal stromal cells (MSCs) with specific gene profile may represent an alternative method to provide solutions for targeted therapeutic applications.

  10. The analysis of the effect of the individual SNPs(PON1, IL-6, ITGB3, and ALDH2 ) and GRS groups on different lipid profile parameters revealed no significant association of any of the tested SNPs with any lipid parameter, however, the GRS groups showed marginally significant for TC and highly significant association for TG, LDL-c and HDL-c

  11. In a Chinese Han population with dyslipidemia, individuals with A/A or A/G genotypes of rs671 in the Aldehyde Dehydrogenase, Mitochondrial gene have a higher coronary artery disease risk, if they lack physical activity and take fried food regularly, than individuals with G/G genotypes.

  12. aldehyde dehydrogenase 2 (ALDH2) is found to be transcriptionally regulated by VHL and contributes to enhanced anthracyclines cytotoxicity in clear cell renal cell carcinoma cells.

  13. ardiac-specific expression of the human ALDH2 gene in mice augmented myocardial ALDH2 activity but did not improve cardiac function in response to pressure overload. After 12 weeks of transverse aortic constriction , ALDH2 transgenic mice had larger hearts than their wild-type littermates and lower capillary density

  14. Study revealed that the rs10744777 polymorphism in ALDH2 was an independent risk factor for ischemic stroke in Chinese male, but not in Chinese female.

  15. ALDH2 gene polymorphism is associated with liver diseases.

  16. In the 7,966 individuals from the Hakka population of China in this study, the frequencies of the ALDH2 genotypes *1/*1, *1/*2 and *2/*2 were 52.03%, 39.67%, and 8.30%, respectively; 47.97% of the individuals were found to carry the ALDH2*2 genotype, which was associated with a deficiency in the aldehyde dehydrogenase (ALDH2) enzyme activity.

  17. Here the authors demonstrate that a missense single nucleotide polymorphism in the ALDH2 gene, rs671 (ALDH2*2), is significantly associated with hip fracture (odds ratio = 2.48, 95% confidence interval: 1.20-5.10, p = 0.021). The rs671 single nucleotide polymorphism was also significantly associated with osteoporosis development (odds ratio = 2.04, 95% confidence interval: 1.07-3.88, p = 0.040).

  18. the mediation effects of single nucleotide polymorphisms (SNPs) in the ADH1B and ALDH2 genes on hepatocellular carcinoma, were investigated.

  19. Three novel SNPs of ALDH2 gene were suggestively significantly associated with serum folate levels.

  20. Coronary Artery Disease patients with mutated ALDH2 genotype are inclined to suffer with coronary artery lesions than wild type subjects.

Cow (Bovine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells.

  2. ACADM and ALDH2 were predicted to be the target genes of miR-224

  3. analysis of bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases ALDH1 and ALDH2

Mouse (Murine) Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) interaction partners

  1. These results suggested that decrease and deficiency of ALDH2 activity would significantly increase the sensitivity to ETBE-induced genotoxicity as well as hepatotoxic effects after exposure even to low concentrations of ethyl tertiary butyl ether .

  2. ALDH2 deficiency attenuates compensatory cardiac hypertrophy through regulating Akt but not PI3K phosphorylation early after transverse aorta constriction. In vitro, phosphorylation of Akt was significantly accentuated and PTEN expression was reduced while PI3K phosphorylation remained unchanged in stretched cardiomyocytes pretreated by Alda-1 (a small-molecule activator of ALDH2).

  3. data revealed that ALDH2 enzyme may suppress myocardial autophagy possibly through a complex JNK-Bcl-2 and IKKbeta-AMPK-dependent mechanism en route to accentuation of myocardial remodeling and contractile dysfunction in aging.

  4. results thus suggest that ALDH2 is indispensable for the favorable cardiac effect of low-to-moderate alcohol consumption and ALDH2 deficiency may lead to unexpected cardiac dysfunctions via enhancing myocardial apoptosis and necroptosis.

  5. ALDH2 activation improved ethanol-induced cardiac damage and decreased angiotensin and angiotensin II in hearts.

  6. ALDH2 overexpression inhibited the expression of c-Jun N-terminal kinase (JNK)-1, activated protein 1 (AP-1), insulin receptor substrate 1 (IRS-1), 4- hydroxynonenal, caspase 3, transforming growth factor beta1, and collagen I and III, and enhanced Akt phosphorylation.

  7. Study found ALDH2*2 diabetic mice exhibit diastolic dysfunction and preserved systolic function at rest, similar to clinical heart failure of preserved ejection fraction.

  8. ALDH2 deficiency reduced the therapeutic effect of ALDHbr cells in the mice model of ischemic hind limb due to decreased anaerobic glycolysis and increased mitochondrial ROS generation.

  9. osteoblast differentiation is impaired in the absence of Aldh2 gene.

  10. ALDH2 plays a protective role in cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and detoxifying reactive aldehydes.

  11. Deficiency in ALDH2 activity may contribute to increased cisplatin sensitivity and cytotoxicity by producing more ROS by the treatment.

  12. our data suggest that ALDH2 serves as an indispensable cardioprotective factor against insulin resistance-induced cardiomyopathy with a mechanism possibly associated with facilitation of the Sirt3-dependent PGC-1alpha deacetylation.

  13. Findings suggested that ALDH2 can influence atherosclerotic plaque development and vulnerability, and inflammation via MAPK, NF-kappaB and AP-1 signaling pathways.

  14. ALDH2 deficiency triggers decompensation of metabolic reserves and energy metabolism disturbances in early diabetic hearts.

  15. Results show that ALDH2 is required for a normal adipogenesis and its expression in white adipose tissue is negatively correlated with obesity. Also, the study provides evidence that PKCepsilon-ALDH2 pathway positively regulates adipocyte differentiation by regulation of PPARgamma transcriptional activity.

  16. In knock-in mice in which ALDH2 enzymatic activity is maximally reduced, cardio-protection in ischemic-reperfused hearts is lacking.

  17. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) overexpression attenuates exhaustive exercise-induced mitochondrial oxidative stress

  18. ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells.

  19. capable of modulating the aggressive, highly metastatic phenotype of hepatocellular carcinomas in vivo

  20. prolonged treatment of apoE(-/-) mice with Alda-1 led to the beneficial changes in the expression of genes and proteins related to neuroplasticity and mitochondrial function.

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) Antigen Profile

Protein Summary

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with ALDH2

  • aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 1 (aldh2.1) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) L homeolog (aldh2.L) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (aldh2) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (ALDH2) antibody
  • aldehyde dehydrogenase 2 (aldh2) antibody
  • aldehyde dehydrogenase (RHA1_RS43090) antibody
  • aldehyde dehydrogenase (NAD(+)) (aldH2) antibody
  • hypothetical protein (OE_RS03015) antibody
  • aldehyde dehydrogenase (aldH2) antibody
  • aldehyde dehydrogenase 2 family (mitochondrial) (Aldh2) antibody
  • aldehyde dehydrogenase 2, mitochondrial (Aldh2) antibody
  • Ahd-5 antibody
  • Ahd5 antibody
  • ALDH-E2 antibody
  • aldh2 antibody
  • aldh2a antibody
  • ALDHI antibody
  • ALDM antibody
  • MGC80785 antibody
  • rf2b antibody
  • zgc:63786 antibody

Protein level used designations for ALDH2

aldehyde dehydrogenase 2 , aldehyde dehydrogenase 2 family (mitochondrial) , aldehyde dehydrogenase 2 family (mitochondrial)a , aldehyde dehydrogenase 2.1 , mitochondrial aldehyde dehydrogenase 2 , ALDH2B6 , mitochondrial aldehyde dehydrogenase RF2B , aldehyde dehydrogenase , aldehyde dehydrogenase (NAD(+)) , ALDH class 2 , ALDH-E2 , aldehyde dehydrogenase, mitochondrial , aldehyde dehydrogenase, mitochondrial-like , acetaldehyde dehydrogenase 2 , liver mitochondrial ALDH , nucleus-encoded mitochondrial aldehyde dehydrogenase 2 , ALDH1 , aldehyde dehydrogenase 2, mitochondrial , mitochondrial aldehyde dehydrogenase , ALDHI , AHD-M1

GENE ID SPECIES
393462 Danio rerio
446857 Xenopus laevis
448267 Xenopus (Silurana) tropicalis
452252 Pan troglodytes
542567 Zea mays
713451 Macaca mulatta
4226489 Rhodococcus jostii RHA1
5776113 Staphylococcus aureus subsp. aureus USA300_TCH1516
5952690 Halobacterium salinarum R1
9005267 Rhodobacter capsulatus SB 1003
100171596 Pongo abelii
100217978 Taeniopygia guttata
100338523 Oryctolagus cuniculus
100388478 Callithrix jacchus
217 Homo sapiens
29539 Rattus norvegicus
610941 Canis lupus familiaris
733685 Sus scrofa
508629 Bos taurus
416880 Gallus gallus
11669 Mus musculus
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