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Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).. Additionally we are shipping ALKBH5 Proteins (4) and many more products for this protein.
Showing 10 out of 34 products:
Human Polyclonal ALKBH5 Primary Antibody for IHC, IHC (p) - ABIN4279674
Zhang, Samanta, Lu, Bullen, Zhang, Chen, He, Semenza: Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. in Proceedings of the National Academy of Sciences of the United States of America 2016
Show all 2 Pubmed References
Overexpression of ALKBH5 in MIA-PaCa-2 and BxPC-3 cells, demonstrats that ALKBH5 could inhibit cell migration and invasion and ALKBH5 inhibits cell motility by demethylating and increasing expression of KCNK15- AS1.
N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A (show GPM6A Antibodies)-recognising proteins, including FTO (show FTO Antibodies) and ALKBH5.
ALKBH5 knockdown in breast cancer cells significantly decreased metastasis from breast to lungs in immunodeficient mice
ALKBH5-FOXM1 (show FOXM1 Antibodies) pathway is critical for glioblastoma proliferation and tumorigenesis.ALKBH5 expression increases in glioblastoma stem-like cells and predicts poor survival in glioblastoma patients.
HIF-dependent ALKBH5 expression mediates enrichment of BCSCs in the hypoxic tumor microenvironment
The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population.
Structures of human ALKBH5 demethylase (show MBD2 Antibodies) reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms.
findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB (show ALKBH Antibodies) members
ALKBH5 is a RNA demethylase (show MBD2 Antibodies) and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells.
This study identified reversible m6A (show GPM6A Antibodies) modification as a critical mechanism of posttranscriptional control of mRNA fate in late meiotic and haploid spermatogenic cells.
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
RNA demethylase ALKBH5
, alkylated DNA repair protein alkB homolog 5
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
, probable alpha-ketoglutarate-dependent dioxygenase ABH5
, oxoglutarate and iron-dependent oxygenase domain containing