Amiloride-Sensitive Cation Channel 2, Neuronal Proteins (ACCN2)

ACCN2 encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Additionally we are shipping Amiloride-Sensitive Cation Channel 2, Neuronal Antibodies (155) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACCN2 41 P78348
Rat ACCN2 ACCN2 79123 P55926
ACCN2 11419 Q6NXK8
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Top Amiloride-Sensitive Cation Channel 2, Neuronal Proteins at

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days

ACCN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

More Proteins for Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Interaction Partners

Human Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Ligand Docking to the Acidic Pocket of the Proton-Gated Ion Channel Asic1A.

  2. The polymorphism status of the ASIC1 and IL-6 genes.

  3. Panic disorder (PD) patients appear to display polymorphisms in the ACCN gene and elevated levels of TDAG8 mRNA. [systematic review, meta-analysis ]

  4. Data show that acid-sensing ion channel 1a (ASIC1a) expression level was significantly higher in gastric carcinoma (GC) tissues.

  5. Study shows that bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel. Site-directed mutagenesis demonstrated that the amino acid residue G433 is critically involved in the potentiating effect of bile acids on ASIC1a activation by protons.

  6. Genetic variants in the ACCN2 are associated with differential sensitivity to CO2.

  7. The deactivation of ASIC1 was steeply dependent on the pH, spanning nearly three orders of magnitude from extremely fast at pH 8 to very slow at pH 7.

  8. Results show that the "acidic pocket," the binding site of several toxins, is not essential for channel function but has, rather, a modulatory role. Furthermore, the study describes the structural rearrangements occurring in this domain during ASIC activity, and highlight the importance of the "palm" domain in channel opening and current decay.

  9. our results suggest that ASIC1a is critical for liver cancer cell proliferation and its deregulation is frequently linked to liver cancer

  10. the data demonstrate a functional link between ASICs and [Ca(2+)]i/RhoA pathway, which contributes to the acidity-induced epithelial-mesenchymal transition.

  11. ASIC1 contributes to breast cancer pathogenesis in response to acidic tumor microenvironments

  12. The results show that acid-sensing ion channel 1, acid-sensing ion channel 2, and acid-sensing ion channel 3 are expressed in A549 cells at the messenger RNA and protein levels, and acid-sensing ion channel-like currents were elicited by extracellular acid stimuli.

  13. Data show that acid sensing ion channel 1a (ASIC1a) mediated calcium influx, which resulted in the activation of PI3K/AKT signaling and increased drug resistance, suggesting that ASIC1a/Ca(2+)/PI3K/AKT signaling represents a pathway that regulates drug resistance, thus offering a potential target for chemotherapy of hepatocellular carcinoma (HCC).

  14. Downregulation of ASIC1 inhibits gastric cancer growth via decreasing autophagy, therefore this strongly suggests a therapeutic role for ASIC1 in gastric cancer.

  15. The C mutated allele for ACCN2 rs685012 polymorphism was more frequent in panic disorder patients. The ACCN2 TT/ADORA2A CT diplotype were more represented in controls. This suggests a role for ACCN2 rs685012 polymorphism in PD development in Caucasian

  16. ASICs may enhance susceptibility to epileptogenesis in the piriform cortex.

  17. analysis of a major ASIC1a homotetramer at the surface membrane of the cell expressing functional ASIC1a channel

  18. Our findings support previously reported associations between ASIC1 and panic/anxiety, but not other genes previously associated with anxiety disorders. The

  19. Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  20. A novel interaction between ASIC1 and integrin-Beta1, mediated by alpha-actinin was determined in glioma tumor cells.

Mouse (Murine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Data suggest a mechanism mediated by acid-sensing ion channel 1a (ASIC1a) that promotes the excitatory synaptic function underlying striatum-related procedural learning and memory.

  2. ASIC1 activates organum vasculosum lamina terminalis neurons which project to the paraventricular nucleus which detects increases in Na(+) in body fluids.

  3. In addition to enhanced RhoA-mediated Ca(2+) sensitization following CH, RhoA can also activate a Ca(2+) signal by facilitating ASIC1a plasma membrane localization and Ca(2+) influx in pulmonary hypertension.

  4. Overall, these results suggest that a functional coupling between ASIC1a and metabotropic glutamate (mGlu) receptors occurs and might contribute to the synaptic alterations associated with Alzheimer's disease.

  5. ASICs promote the inflammatory response and apoptosis of RAW 264.7 cells.

  6. These data demonstrate the involvement of an ASIC1a-mediated insular synaptic depression mechanism in extinction learning.

  7. ASIC1a expression in astrocytes. Injection of rAAV-ASIC1a-shRNA into the dentate gyrus of the wide type TLE mouse model resulted in the inhibition of astrocytic ASIC1a expression and a reduction in spontaneous seizures

  8. The findings of this study suggested a key role for ASIC1a in normal olfactory function.

  9. Study suggests Acid-sensing ion channel 1a plays an inhibitory role in vasodilation in response to external protons, functional hyperemia, and exercise capacity.

  10. Asic1 showed heightened mRNA expression, coherent with the repeated cross-fostering paradigm (RCF)-mice's respiratory hypersensitivity to CO2 and altered nociception.

  11. Notch1 signaling may be required for ASIC1a-mediated neurite growth and neuronal differentiation in neuroblastoma cells.

  12. The authors observed no preference for sodium at the "GAS belt" in the central constriction. Instead, they identified a band of glutamate and aspartate side chains at the lower end of the pore that enables preferential sodium conduction.

  13. Asic1a KO mice exhibited prominent deficits in multiple fear-related behaviors.

  14. ASIC1a Deficient Mice Show Unaltered Neurodegeneration in the Subacute MPTP Model of Parkinson Disease

  15. The manuscript demonstrates that postsynaptic neurons of the medial nucleus of the trapezoid body at the mouse calyx of Held synapse express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by protons (coreleased with neurotransmitter from acidified synaptic vesicles). These ASIC-1as contribute to the generation of postsynaptic currents and, more relevant, to calcium influx, which could be

  16. nonselective cation channels ( channels consist of at least one alpha-ENaC and one or more acid-sensing ion channel 1a (ASIC1a) proteins.

  17. ASIC1a is an important mediator of AHR.

  18. Ca(2+) influx through ASIC1 mediates chronic hypoxia and ET-1-induced NFATc3 nuclear import and 2) the scaffolding protein PICK1 is necessary for NFATc3 nuclear import.

  19. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (mGlu) receptor-induced increase in action potential firing.

  20. the potentiation of ASICs by quinine depends on the presence of the ASIC1a, ASIC2a subunits, but not ASIC1b, ASIC3 subunits. Furthermore, we have determined the amino acids in ASIC1a that are involved in the modulation of ASICs by pHi.

Pig (Porcine) Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) interaction partners

  1. Data from models of hyperactive bladder suggest that ASIC1 is involved in ATP release from bladder mucosa stimulated by stretch/acid; studies include evidence ASIC isoforms are expressed in lateral wall, dome, trigone, and neck of detrusor/mucosa.

Amiloride-Sensitive Cation Channel 2, Neuronal (ACCN2) Protein Profile

Protein Summary

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with ACCN2

  • acid sensing ion channel subunit 1 (ASIC1)
  • acid sensing ion channel subunit 1 (Asic1)
  • acid sensing ion channel subunit 1 (asic1)
  • acid-sensing (proton-gated) ion channel 1 (Asic1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (SMARCD1)
  • Accn2 protein
  • AI843610 protein
  • ASIC protein
  • ASIC1 protein
  • ASIC1a protein
  • B530003N02Rik protein
  • BNaC2 protein

Protein level used designations for ACCN2

Cation channel, amiloride-sensitive, neuronal, 2 , acid-sensing ion channel 1 , acid-sensing ion channel 1a protein , amiloride-sensitive cation channel 2, neuronal , brain sodium channel 2 , BNaC2 , proton gated cation channel ASIC1 , Amiloride-sensitive cation channel 2, neuronal , acid sensing ion channel , degenerin 2 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 , acid-sensing (proton-gated) ion channel 1

41 Homo sapiens
79123 Rattus norvegicus
426883 Gallus gallus
451888 Pan troglodytes
477612 Canis lupus familiaris
538244 Bos taurus
100194955 Salmo salar
11419 Mus musculus
100355858 Oryctolagus cuniculus
713320 Macaca mulatta
100517467 Sus scrofa
100059851 Equus caballus
100720903 Cavia porcellus
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