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ALAD genetic polymorphisms contribute to high blood lead levels in occupational exposed workers and may predict risk of lead poisoning.
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The delta-aminolevulinate dehydratase activity was significantly lower in pregnant women with gestational diabetes mellitus.
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The ALAD gene influences bone density among lead workers.
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The frequencies of genotype and allelic variants of ALAD rs1800435 did not differ significantly between patients with essential tremor (ET) and controls, and were not influenced by gender. Subjects carrying the ALAD rs1800435CC genotype (wild-type) and the HMOX2 rs1051308GG genotype or the HMOX2 rs1051308G allele had significantly decreased risk for ET.
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ALAD SNP rs818708 is significantly associated with risk of lead poisoning.
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Overexpression of delta-aminolevulinate dehydratase (ALAD)suppresses breast cancer cell proliferation and invasion and inhibits the epithelial-mesenchymal transition phenotype.
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Delta-aminolevulinate dehydratase activity and oxidative stress markers were significantly lowered in preeclampsia.
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Results show statistically significant association between the maternal ALAD G177C polymorphism and placental lead levels.
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Maternal ALAD gene polymorphism can affect early neonatal neurobehavioral development by influencing the blood lead level.
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Genetic variation of ALAD is associated with blood lead level.
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This study investigated the delta-aminolevulinate dehydratase (delta-ALA-D) activity in whole blood as well as the parameters of oxidative stress, in lung cancer.
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Blood lead level affected ALAD but not GPx activities, and these were not modulated by polymorphisms in ALAD and GPx genes.
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Study reveals relationship between ALAD genetic polymorphisms and basic lead toxicological parameters in occupationally exposed workers.
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This study showed that ALAD2 and hPEPT2*2 may be valuable markers of risk, and indicate novel mechanisms of lead-induced neurotoxicity
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The ff carriers in VDR FokI polymorphism were more susceptible to the effect of lead on the balance system, while other VDR or ALAD genotypes did not significantly modify the effect.
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The results indicate that the ALAD1-2/2-2 genotype may have a protective effect in terms of urinary aminolevulinic acid for environmentally lead exposed boys.
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Report the effect of ALAD polymorphism on hematopoietic, hepatic and renal toxicity from lead in occupational exposure workers.
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Genetic variation in ALAD may modify associations between Pb and prostate cancer
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The results lend support to the notion that ALAD polymorphism exerts no marked impact on lead body burden.
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Workers with the ALAD 1-1 genotype were associated with higher blood lead levels than those with the ALAD 1-2 genotype.
