Amyloid beta Proteins (Abeta)

Abeta encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Additionally we are shipping beta Amyloid Antibodies (176) and beta Amyloid Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Abeta 351 P05067
Rat Abeta Abeta 54226 P08592
Mouse Abeta Abeta 11820 P12023
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Top beta Amyloid Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human Un-conjugated 50 μg 9 to 11 Days
Escherichia coli (E. coli) Human Un-conjugated   100 μg 11 to 16 Days
Synthetic Human Un-conjugated   1 mg 3 to 4 Days

Abeta Proteins by Origin and Source

Origin Expressed in
Human ,

More Proteins for Amyloid beta (Abeta) Interaction Partners

Human Amyloid beta (Abeta) interaction partners

  1. These results suggest that Abeta could induce autophagy in RPE cells, which provided a potential protective mechanism for the retina cells that encountered Abeta deposition.

  2. This study found the L723P mutation to cause local unfolding of the C-terminal turn of the APP Transmembrane Domain helix and increase its accessibility to water required for cleavage of the protein backbone by gamma-secretase in the epsilon-site, thus switching between alternative ("pathogenic" and "non-pathogenic") cleavage cascades.

  3. Both wild-type and L-isoAsp23 protofilaments adopt beta-helix-like folds with tightly packed cores, resembling the cores of full-length fibrillar Abeta structures, and both self-associate through two distinct interfaces.

  4. There was no statistically significant difference in the levels of CSF A[beta]1-42 between the former athletes with multiple concussions group and healthy control group.

  5. The B6.Cg-Tg(PDGFB-APPSwInd)20Lms/2Mmjax (J20) mouse strain (#006293: Jackson Laboratory) carries a human APP695 transgene harboring the aggressive Swedish and Indiana substitutions. Sex-specific biochemical and behavioral phenotypes are observed in young human APP mice. Depression-like behavior does not align with cognitive deficits, particularly in very young, female hAPP mice.

  6. The present results suggested that APP knockdown may significantly inhibit the development of nasopharyngeal carcinoma by suppressing cell viability, migration and invasion, and by inhibiting the epithelialmesenchymal transition process via downregulation of the MAPK signaling pathway.

  7. These data provide valuable insights in understanding GRN-3's ability to modulate Abeta-induced toxicity under redox control and presents a new perspective toward AD pathology.

  8. In this study, the analytical capabilities of MALDI-TOF/TOF mass spectrometry for relative quantitation of isoAsp7 in ABETA (1-42) and ABETA(1-16) were investigated.

  9. oligomeric Abeta can profoundly disrupt the bilayer, visualized as widespread lipid extraction and subsequent deposition, which can be likened to an effect expected from the action of a detergent.

  10. The N-terminal sequence Xaa-Xaa-His is known as an amino terminal copper and nickel binding motif (ATCUN), which avidly binds Cu(II). Cu(II) bound to this particular ATCUN site is redox silent, but the second Cu(II) site is redox active and can be readily reduced with ascorbate.

  11. Thirteen of 148 (8.8%) individuals had possible pathogenic APP, PSEN1, or PSEN2 variants, including 2 (15.4%) APP variants, 8 (61.5%) PSEN1 variants, and 3 (23.1%) PSEN2 variants

  12. Synaptic dysfunction caused by presenilin-1 mutant and amyloid precusor protein duplication secretomes is mediated by Abeta peptides, whereas trisomy of chromosome 21 (trisomy 21) neuronal secretomes induce dysfunction through extracellular tau.

  13. In invasive cells, MT1-MMP endocytosis to the endolysosomal reservoir compartment requires flotillin 1 and flotillin 2.

  14. These data demonstrate a key role for proteolysis of the C-terminal of APP by gamma-secretase in neuronal dysfunction in monogenic Alzheimer's disease.

  15. a Drosophila Alzheimer's disease (AD) model expressing a secreted form of human amyloid-beta42 peptide showed that it recapitulates key aspects of AD pathology, including neuronal death and impaired long-term memory.

  16. Beta-amyloid peptide(1-42) (Abeta1-42) : phosphorylated Tau (p-Tau) ratio has potential for being implemented in the clinical routine for differential diagnosis between AD and other dementias and to distinguish underling pathology such as neurodegenerative disease.

  17. CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production.

  18. miR-346 plays a role in upregulation of APP in the CNS and participates in maintaining APP regulation of Fe, which is disrupted in late stages of AD.

  19. analysis of the interaction between monomeric Abeta40/42 and HSA using surface plasmon resonance spectroscopy

  20. Structural dynamics of dipeptides and ABETA (25-35) in aqueous solution were demonstrated

Mouse (Murine) Amyloid beta (Abeta) interaction partners

  1. the present findings suggested that knockdown of Navb2 reversed the APP/PS1 mutationinduced deficiency in amyloid b degradation by regulating NEP.

  2. the contribution of cholinergic basal forebrain neuronal p75(NTR) to the progression of Alzheimer's disease (AD) by removing p75(NTR) from cholinergic neurons in the APP/PS1 familial AD mouse strain.

  3. Fe(3+) accelerates endocytic internalization of extracellular Abeta1-42, enhances Abeta1-42-induced caspase-3/caspase-4 activation.

  4. These findings provide insights into the therapeutic potential of non-amyloidogenic processing of APP in complex I-related neurodegeneration.

  5. show a novel function for Par3 in regulating polarized convergence between APP and BACE1 in hippocampal neurons

  6. Proteasome inhibition precludes APP axonal transport by enhancing its endo-lysosomal delivery, where beta-cleavage is induced.

  7. CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production.

  8. App(-/-) mice have higher levels of insulin-degrading enzyme (IDE) mRNA, protein, and activity. Regulation of IDE by APP was widespread across numerous tissues, including liver, skeletal muscle, and brain as well as cell types within neural tissue. App-/- mice failed to develop impairment of glucose tolerance on a high-fat, high-sucrose diet.

  9. The findings demonstrate that chronic noise exposure exacerbated Alzheimer's disease-like neuropathology, possibly by disrupting Wnt signaling and triggering aberrant tau hyperphosphorylation and amyloid beta peptides in the prefrontal cortex and hippocampus.

  10. A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-beta oligomers.

  11. Together these data indicate that ONA induces APP expression and that gamma-secretase cleavage of APP releases AICD, which upregulates JNK3 leading to RGC death. This pathway may be a novel target for neuronal protection in optic neuropathies and other forms of neurotrauma.

  12. In addition to regulating aspects of neuronal metabolism, APP is an important regulator of whole body energy expenditure and glucose homeostasis under high fat feeding conditions.

  13. These findings indicate that under physiological conditions, expression of APP in cerebral vascular endothelium plays an important protective function by maintaining constitutive expression of eNOS .

  14. NRBF2 plays an important role in regulating degradation of APP-C-terminal fragments through modulating autophagy.

  15. These results provide evidence that both central circadian rhythms and local clock function influence Abeta dynamics and plaque formation.

  16. These data identified APP and APLP2 as modulators of normal myelination and demyelination/remyelination conditions.

  17. these findings suggest that endogenous Abeta is involved in memory forgetting in the normal brain.

  18. pterostilbene attenuated the neuroinflammatory response induced by Abeta1-42 in microglia through inhibiting the NLRP3/caspase-1 inflammasome pathway, indicating that pterostilbene might be an effective therapy for AD.

  19. Abeta40 and Abeta42 demonstrated distinct distribution kinetics in plasma and brain compartments, and insulin differentially modulated their distribution.

  20. APP/GBR complex formation links presynaptic GBR trafficking to Abeta formation.

beta Amyloid (Abeta) Protein Profile

Protein Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Gene names and symbols associated with Amyloid beta Proteins (Abeta)

  • amyloid beta precursor protein (APP)
  • amyloid beta precursor protein (app)
  • amyloid beta precursor protein (App)
  • amyloid beta (A4) precursor protein (App)
  • aaa protein
  • Abeta protein
  • Abpp protein
  • ad1 protein
  • Adap protein
  • Ag protein
  • appi protein
  • betaApp protein
  • ctfgamma protein
  • Cvap protein
  • E030013M08Rik protein
  • PN-II protein
  • pn2 protein

Protein level used designations for Amyloid beta Proteins (Abeta)

alzheimer disease amyloid protein , amyloid beta A4 protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid A4 protein homolog , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , ABPP , AG , amyloid A4 , amyloidogenic glycoprotein , appican , protease nexin II

351 Homo sapiens
448208 Xenopus (Silurana) tropicalis
100427716 Macaca mulatta
54226 Rattus norvegicus
11820 Mus musculus
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