Angiotensin II Receptor-Associated Protein (AGTRAP) ELISA Kits

Human Angiotensin II Receptor-Associated Protein (AGTRAP) interaction partners

1. A role for AT1 receptor-associated proteins in blood pressure regulation

2. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (show AGTR1 ELISA Kits), plays a protective role against the development of systemic insulin (show INS ELISA Kits) resistance via regulatory effects on adipose tissue function.

3. The phosphatidylinositol transfer protein RdgBbeta (show PITPNC1 ELISA Kits) binds 14-3-3 (show YWHAQ ELISA Kits) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).

4. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.

5. CSF (show CSF2 ELISA Kits) angiotensin II, ACE (show ACE ELISA Kits), and ACE2 (show ACE2 ELISA Kits) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (show AQP4 ELISA Kits) antibody, reflecting severe destruction of perivascular astrocytes

6. Small interfering RNA significantly attenuates angiotensin II type 1 receptor (show AGTR1 ELISA Kits)-stimulated inositol phosphate formation.

7. cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein

8. isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (show EPHA3 ELISA Kits)-293 cells

9. CAML (show CAMLG ELISA Kits) is an important signal transducer for the actions of Ang II (show AGT ELISA Kits) in regulating the calcineurin-NFAT (show NFATC1 ELISA Kits) pathway and the interaction of CAML (show CAMLG ELISA Kits) with ATRAP may mediate the Ang II (show AGT ELISA Kits) actions in vascular physiology

Mouse (Murine) Angiotensin II Receptor-Associated Protein (AGTRAP) interaction partners

1. verexpression of ATRAP induced adiponectin expression both in adipose tissue and primary adipocyte. Our data revealed that adipose ATRAP plays an important role in preventing metabolic disorders and adiponectin possibly mediates the effects of adipose ATRAP.

2. ATRAP plays an important role in inhibiting kidney aging, possibly through sirtuin1 (show SIRT1 ELISA Kits)-mediated mechanism independent of blocking AT1R signaling, and further protecting normal life span.

3. Results presented in this study suggested that the enhancement in adipose ATRAP plays a protective role against the development of diet-induced visceral obesity and insulin (show INS ELISA Kits) resistance through improvement of adipose inflammation and function via the suppression of overactivation of adipose AT1R signaling.

4. Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.

5. These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.

6. ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.

7. Identify Atrap as a novel regulatory protein (show TGFB1 ELISA Kits) of the cardiac Ca(2+)-ATPase SERCA2a (show CA-P60A ELISA Kits). Suggest that Atrap enhances the activity of SERCA2a (show ATP2A2 ELISA Kits) and, consequently, facilitates ventricular relaxation.

8. These results suggest that increased formation of AT1R-P2Y6R heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT ELISA Kits).

9. although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct

10. Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.