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ANKRD12 encodes a member of the ankyrin repeats-containing cofactor family.
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Study revealed that ANKRD12 mRNA were down regulated in CRC (show CALR Antibodies) tumor tissues and low ANKRD12 expression was correlated with liver metastasis and poor survival of CRC (show CALR Antibodies) patients.
ADA3 (show TADA3 Antibodies) is a newly identified target of the ANCO proteins, which may modulate co-activator function in a transcription-factor-specific manner
This gene encodes a member of the ankyrin repeats-containing cofactor family. These proteins may inhibit the transcriptional activity of nuclear receptors through the recruitment of histone deacetylases. The encoded protein interacts with p160 coactivators and also represses transcription mediated by the coactivator alteration/deficiency in activation 3 (ADA3). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ankyrin repeat domain-containing protein 12
, ankyrin repeat-containing cofactor 2
, ankyrin repeat domain 12
, ankyrin repeat domain-containing protein 12-like