Annexin A6 Proteins (ANXA6)

Human Annexin A6 (ANXA6) interaction partners

1. Annexin A4 binds to artificial membranes and generates curvature force initiated from free edges, whereas annexin A6 induces constriction force.

2. This review will discuss how the multiple scaffold functions may enable AnxA6 to modulate migratory cell behavior in health and disease

3. Immunoprecipitation of the products obtained from the transcription/translation system using various anti-annexin A6 antibodies confirmed the presence of several isoforms and suggested that this protein might be present in different configurations.

4. AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release.

5. High ANXA6 expression is associated with neoplasms.

6. stable or transient AnxA6 overexpression in HuH7 cells led to elevated lipid droplet numbers/size and neutral lipid staining under control conditions

7. Annexin VI is enriched in calcifying valve interstitial cell derived-matrix vesicles from patients with end stage renal disease-induced hypercalcemia and aortic valve calcification.

8. These findings suggest that cancer-associated fibroblasts -tumor cell crosstalk supported by ANXA6+ EVs is predictive of pancreatic ductal adenocarcinoma aggressiveness, highlighting a therapeutic target and potential biomarker for pancreatic ductal adenocarcinoma.

9. The current study shows that AnxA6 is specifically reduced in human hepatocellular carcinoma suggesting a role of this protein in hepatocarcinogenesis.

10. Data suggest that reduced ability of AnxA6-expressing cells to migrate is associated with decreased cell surface expression of integrins alphaVbeta3 and alpha5beta1.

11. ANXA6 was detected as a novel systemic lupus erythematosus susceptibility gene, with several single-nucleotide polymorphisms (SNPs) contributing independently to the association with disease

12. ANXA6 is a EZH2 target gene involving gastric cellular proliferation.

13. Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains

14. The rapid degradation of activated EGFR in AnxA6-depleted invasive tumor cells underlies their sensitivity to EGFR-targeted inhibitors.

15. These results show that influenza A virus replication depends on maintenance of the cellular cholesterol balance and identify AnxA6 as a critical factor in linking the virus to cellular cholesterol homeostasis.

16. TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking and alcohol intake affect risk of psoriasis.

17. Influence of the 524-VAAEIL-529 sequence of annexins A6 in their interfacial behavior and interaction with lipid monolayers.

18. Ca(2+) is the main factor which regulates the interaction of AnxA6 with monolayers composed of neutral lipids, determine AnxA6 localization in cholesterol and sphingomyelin enriched microdomains, thus contributing to the etiology of the NPC disease.

19. AnxA6 is a new PKCalpha scaffold to promote PKCalpha-mediated EGFR inactivation.

20. anxA6 inhibits Drp1 activity, and Ca(2+)-binding to anxA6 relieves this inhibition to permit Drp1-mediated mitochondrial fission

Mouse (Murine) Annexin A6 (ANXA6) interaction partners

1. Annexin A6-deficient mice showed increased sensitivity to mechanical stimuli, overexpression of annexin A6 in sensory neurons attenuated mechanical pain in a mouse model of osteoarthritis

2. AnxA6 contributing to the fine-tuning of hepatic glucose metabolism with potential consequences for the systemic control of glucose in health and disease.

3. Findings define a novel role for AnxA6 in articular chondrocytes via its modulation of Wnt/beta-catenin and NF- kappaB signaling activities and the cross-talk between these two signaling pathways.

4. AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.

5. AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release.

6. morphological analysis of liver sections from annexin A6-KO mice revealed significantly lower lipid droplet numbers compared to wildtype animals

7. Evidence for annexin A6-dependent plasma membrane remodelling of lipid domains

8. Transient knockdown of annexin A6 and calsequestrin 1 protein of high-active mice with vivo-morpholinos resulted in decreased physical activity levels (P = 0.001).

9. Anxa6 is a modifier of muscular dystrophy and membrane repair after injury.

10. anxA6 inhibits Drp1 activity, and Ca(2+)-binding to anxA6 relieves this inhibition to permit Drp1-mediated mitochondrial

11. Annexins and collagen X may rather fulfill functions in growth plate cartilage not directly linked to the mineralization process.

12. These results indicate that annexins A5 and A6 may not represent the essential annexins that promote mineralization in vivo.

13. cell surface annexin VI may function as an acidic pH binding site or receptor and may also function as a co-receptor with LRP-1 at neutral pH

14. Annexin VI regulation of myocardial contraction.

15. distinct functions of AnxA6 isoforms in membrane dynamics

Cow (Bovine) Annexin A6 (ANXA6) interaction partners

1. AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.

2. The results showed that alkaline phosphatase activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake.