ArfGAP with Dual PH Domains 1 Proteins (ADAP1)

binds inositol(1,3,4,5)tetrakisphosphate (InsP4) and phosphatidylinositol(3,4,5)trisphosphate (PtdInsP3)\;involved in inositol phosphate or inositol lipid signal transduction [RGD, Feb 2006].. Additionally we are shipping ADAP1 Antibodies (56) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ADAP1 11033 O75689
Mouse ADAP1 ADAP1 231821  
Rat ADAP1 ADAP1 171097  
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Top ADAP1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days

ADAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

More Proteins for ArfGAP with Dual PH Domains 1 (ADAP1) Interaction Partners

Human ArfGAP with Dual PH Domains 1 (ADAP1) interaction partners

  1. Analyzed ArfGAP with dual PH domains 1 (ADAP1) using mass spectrometry and found that ADAP1 is phosphorylated at Y364.

  2. This review highlights the functions of the neuron-specific protein ADAP1 in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1. [review]

  3. SH-SY5Y cells, stably transfected with GFP-tagged-p42(IP4), show an enhanced NRD protein expression already at an earlier time point after retinoic acid stimulation.

  4. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1).

  5. Full-length KIF13B and CENTA1 form heterotetramers that can bind four phosphoinositide molecules in the vesicle and transport it along the microtubule.

  6. The ARFGAP domain of p42IP4 is involved in the interaction and co-localization with RanBPM protein, without being the only interaction site.

  7. the up-regulated p42(IP4) in Alzheimer's disease neurons may serve as a docking protein to recruit signaling molecules such as different subtypes of casein kinase I to the plasma membrane.

  8. Results show that nucleolin interacts with centaurin-alpha(1) protein, suggesting that centaurin-alpha(1) may be part of a ribonucleoprotein complex.

  9. centaurin-alpha1 negatively regulates ARF6 activity by functioning as an in vivo PIP3-dependent ARF6 GAP

  10. p42IP4 receptor is expressed and distributed throughout the cell in HEK cell lines and is located on chromosome 7, position 7p22.3.

  11. Authors propose alternative concepts of how elevated levels of p42IP4 might relate to its interaction with nucleolin in the pathomechanisms of Alzheimer's disease.

  12. The centaurin, alpha 1 protein is a high-affinity PtdIns(3,4,5)P3-binding protein enriched in brain. Sequence analysis indicates centaurin alpha-1 contains two pleckstrin homology domains, ankyrin repeats and an Arf GAP homology domain.

  13. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2-adrenoceptor internalization.

  14. Centaurin-alpha1 contributes to ERK activation in growth factor signaling, linking the PI3K pathway to the ERK mitogen-activated protein kinase pathway.

  15. Data show that membrane transport of p42(IP4) induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor.

  16. p42IP4 binds to nardilysin via the acidic domain, and that this interaction is controlled by the cognate cellular ligands of p42IP4/centaurin-alpha1

ADAP1 Protein Profile

Protein Summary

binds inositol(1,3,4,5)tetrakisphosphate (InsP4) and phosphatidylinositol(3,4,5)trisphosphate (PtdInsP3)\;involved in inositol phosphate or inositol lipid signal transduction

Gene names and symbols associated with ADAP1

  • ArfGAP with dual PH domains 1 (ADAP1)
  • ArfGAP with dual PH domains 1 (adap1)
  • ArfGAP with dual PH domains 1 L homeolog (adap1.L)
  • ArfGAP with dual PH domains 1 (Adap1)
  • 4930431P11Rik protein
  • Centa1 protein
  • centa2 protein
  • GC1L protein
  • GCS1L protein
  • MGC76109 protein
  • p42IP4 protein

Protein level used designations for ADAP1

centaurin, alpha 1 , ArfGAP with dual PH domains 1 , Centaurin-alpha2 protein , arf-GAP with dual PH domain-containing protein 1-like , arf-GAP with dual PH domain-containing protein 1 , inositol(1,3,4,5)tetrakisphosphate receptor , centaurin-alpha , centaurin-alpha-1 , cnt-a1 , putative MAPK-activating protein PM25

416451 Gallus gallus
394901 Xenopus (Silurana) tropicalis
495044 Xenopus laevis
696246 Macaca mulatta
750938 Pan troglodytes
100410764 Callithrix jacchus
100472030 Ailuropoda melanoleuca
100558369 Anolis carolinensis
397453 Sus scrofa
11033 Homo sapiens
231821 Mus musculus
606942 Canis lupus familiaris
171097 Rattus norvegicus
282176 Bos taurus
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