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ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 Proteins (ASAP3)

ASAP3 encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. Additionally we are shipping ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASAP3 55616 Q8TDY4
ASAP3 230837 Q5U464
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Top ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$13,741.67
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details

ASAP3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3) Interaction Partners

Human ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3) interaction partners

  1. Results show that ASAP3 was amplified in colorectal cancer (CRC) tissues, and its upregulation was associated with poor prognosis of patients with CRC. Also, it promoted growth of colon tumors, and accelerated cell invasion and migration through its binding to NEMO. These results suggest that ASAP3 acts as an oncogene.

  2. The data, for the first time, link ASAP3 with ACTG1 in the regulation of cytoskeletal maintenance and cell motility

  3. ). These data indicate that ASAP3 is elevated in NSCLC and may contribute to cancer development and patients' poor clinical outcome, which is possibly due to its critical roles in regulating cancer invasion.

  4. Phosphorylation of the N-terminal region of ACAP4 (named the Bin, Amphiphysin, and RSV161/167[BAR] domain at Tyr34) is necessary for epidermal growth factor (EGF)-elicited membrane remodeling.

  5. ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration

  6. The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.

  7. ACAP4 is involved in ARF6-mediated cell migration.

  8. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.

Mouse (Murine) ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3) interaction partners

  1. ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.

ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 3 (ASAP3) Protein Profile

Protein Summary

This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with ASAP3

  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (ASAP3)
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (asap3)
  • development and differentiation enhancing factor-like 1 (DDEFL1)
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (Asap3)
  • 9430088F20Rik protein
  • ACAP4 protein
  • CENTB6 protein
  • Ddefl1 protein
  • Gm140 protein
  • UPLC1 protein
  • zgc:113885 protein

Protein level used designations for ASAP3

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1 , development and differentiation enhancing factor-like 1 , ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 , ARF6 GTPase-activating protein , arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 , centaurin, beta 6 , development and differentiation-enhancing factor-like 1 , protein up-regulated in liver cancer 1 , up-regulated in liver cancer 1 (UPLC1)

GENE ID SPECIES
456617 Pan troglodytes
664764 Danio rerio
769389 Gallus gallus
100071599 Equus caballus
100548261 Meleagris gallopavo
100553150 Anolis carolinensis
100583081 Nomascus leucogenys
55616 Homo sapiens
230837 Mus musculus
487377 Canis lupus familiaris
100626125 Sus scrofa
523797 Bos taurus
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