Arginase, Type II Proteins (ARG2)

Human Arginase, Type II (ARG2) interaction partners

1. xpression profiles revealed miR (show MLXIP Proteins)-1299 downregulation concomitant with arginase-2 (ARG2) upregulation in hyperpigmented skin of melasma patients.

2. ARG2 promotes tumorigenesis, and HCMV may contribute to GBM pathogenesis by upregulating ARG2.

3. fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2; results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation

4. Schizophrenia patients had increased arginase II protein expression in the frontal cortex compared to controls.

5. our data provide compelling evidence that human cytomegalovirus reduced the level of microRNA-613 which functions as an anti-onco-miRNA in glioblastoma, primarily by downregulating the expression of arginase-2

6. overexpression of AMPK (show PRKAA1 Proteins) induced arginase II protein expression and viable cells numbers in human Pulmonary artery smooth muscle cell .

7. Data show that transfection with Arginase II-small interfering RNA prevented hypoxia-induced cell proliferation.

8. circulating Arginase 2 concentrations increase in clinical erectile dysfunction (ED) and are associated with increased risk for ED

9. arginase 2 impairs endothelial autophagy independently of the L-arginine ureahydrolase activity through activation of RPS6KB1 (show RPS6KB1 Proteins) and inhibition of PRKAA (show PRKAA2 Proteins), which is implicated in atherogenesis

10. High arginase II expression correlates with poor survival for patients with neuroblastoma (show ARHGEF16 Proteins). Neuroblastoma (show ARHGEF16 Proteins) suppresses T-cell proliferation via arginase II expression and activity.

Mouse (Murine) Arginase, Type II (ARG2) interaction partners

1. The possibility that the Gas6 (show GAS6 Proteins)-Mer (show ERH Proteins)-PI3K/Akt (show AKT1 Proteins)-STAT1 (show STAT1 Proteins)-LXR (show NR1H3 Proteins)-Arg2 pathway plays an essential role for resolving inflammatory response in acute lung injury.

2. ARG2 which hydrolyzes arginine into ornithine and urea, is induced upon obesity, and silencing or loss of ARG2 markedly suppresses pancreatic ductal adenocarcinoma.

3. the finding of this study is that ARG2 contributes to the immune evasion of H. pylori by restricting M1 macrophage activation and polyamine metabolism.

4. diabetes-dependent increase in renal arginase-2 expression also requires arginase-1 (show ARG1 Proteins) expression in macrophages

5. Arginase II expression is reduced in aortic endothelial cells and macrophages following PARP-1 (show PARP1 Proteins) knockout.

6. This study shows for the first time that neurovascular injury after retinal ischemia/reperfusion is mediated through increased expression of Arginase 2.

7. Arg2 KO female (not male) mice are protected from age-associated glucose intolerance and reveal greater glucose induced-insulin (show INS Proteins) release, larger islet size and beta-cell mass, and more proliferative and less apoptotic beta-cells compared with the age-matched WT controls. Arg2 is mainly expressed in acinar cells and is upregulated with aging, which enhances p38 MAPK (show MAPK14 Proteins) activation and release of TNF-alpha (show TNF Proteins).

8. arginase 2 impairs endothelial autophagy independently of the L-arginine ureahydrolase activity through activation of RPS6KB1 (show RPS6KB1 Proteins) and inhibition of PRKAA (show PRKAA2 Proteins), which is implicated in atherogenesis

9. high fat diet enhanced arginase-II expression/activity and p38mapk (show MAPK14 Proteins) activity, which was associated with eNOS (show NOS3 Proteins)-uncoupling as revealed by decreased nitric oxide

10. Arg1 (show ARG1 Proteins) expression is decreased, and Arg2 expression is increased in the newborn congenital obstructive nephropathy and in the mouse model.

Cow (Bovine) Arginase, Type II (ARG2) interaction partners

1. Activity of arginase before and at the time of parturition might be a potential marker for occurrence of metritis, especially in cows that develop retained fetal membranes.

2. results indicate that arginase induction depends in part on epidermal growth factor (EGF (show EGF Proteins)) receptor (show EGFR Proteins) activity, and that EGFR (show EGFR Proteins) inhibitors may attenuate vascular remodeling without affecting nitric oxide release

Rabbit Arginase, Type II (ARG2) interaction partners

1. Kidneys from circulation-restricted fetuses showed arginase-2 protein induction.

2. In heart failure, increased iNOS (show NOS2 Proteins) and arginase II expression results in unchanged NO species and protein S-nitrosylation; with substrate limitation, uncoupled iNOS (show NOS2 Proteins) produces superoxide anions and contributes to contractile dysfunction.