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an L-asparaginase possibly involved in astroglial production of neuroactive S-aspartate. Additionally we are shipping Asparaginase Like 1 Antibodies (93) and Asparaginase Like 1 Kits (12) and many more products for this protein.
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ASRGL1 was closely associated with growth and apoptosis in cervical cancer. Therefore, ASRGL1 may be a novel, potentially effective anticervical cancer therapy.
A panel including p53 (show TP53 Proteins) and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P<0.001) of dying of EEC compared to the low-risk group.
In a prospective setting ASRGL1 validates as a strong prognostic biomarker in endometrial carcinoma. Loss of ASRGL1 is associated with aggressive disease and poor survival.
Our studies suggest that the p.G178R mutation in ASRGL1 leads to photoreceptor degeneration resulting in progressive vision loss.
Multiple negatively charged small molecules interact within the active site of ASRGL1 to act as a base in promoting cleavage.
Reduced expression of ASRGL1, defined as <75% positively stained tumor cells, was significantly associated with poor prognosis and reduced disease-specific survival in endometrioid endometrial adenocarcinoma (EEA).
Human ALP (show ALP Proteins) cDNA was subsequently cloned. It showed 77% identity to the rat ALP (show ALP Proteins) sequence and the gene, ASRGL1 (asparaginase-like 1), mapped to chromosome locus 11q12.3.
ASRGL1 exhibits beta-aspartyl peptidase activity consistent with plant-type asparaginases. ASRGL1 is shown to be an Ntn (show NRTN Proteins) hydrolase for which Thr168 serves as the essential N-terminal nucleophile for intramolecular processing and catalysis.
an L-asparaginase possibly involved in astroglial production of neuroactive S-aspartate
asparaginase like 1
, asparaginase-like 1 protein
, L-asparagine amidohydrolase
, asparaginase-like protein 1
, isoaspartyl dipeptidase
, isoaspartyl peptidase/L-asparaginase
, asparaginase-like 1
, asparaginase-like sperm autoantigen
, glial asparaginase